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The Role of Genotype-Environment Interactions in the Development of Symptoms of Anxiety and Depression in Stress Associated with Disease in a Family Member

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The relationship between the 5-HTTLPR and BDNF Val66Met marker genotypes and symptoms of depression and anxiety associated with stress resulting from severe chronic illness in a family member was studied. Genotyping was performed in groups of 214 unaffected parents of patients with schizophrenia and 100 control subjects. The Met*ss diplotype was associated with increases in depressive tendencies (MMPI test) in the parents of patients but not in the control group, while among parents this was the case in the subgroup of parents whose children had the most severe symptoms. These results suggest that the interaction of polymorphic 5-HTT and BDNF genes may mediate the relationship between objective and subjective burden of disease.

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References

  1. M. V. Alfimova, V. I. Trubnikov, V. V. Bondar, et al., “Psychometrically detected personality anomalies in the relatives of patients with schizophrenia and schizoaffective disorders,” Zh. Nevrol. Psikhiat., 101, No. 8, 1001–104 (2001).

    Google Scholar 

  2. M. V. Alfimova,V. E. Golimbet, G. I. Korovaitseva, et al., “The modulating effect of polymorphism in the serotonin transporter gene on the characteristics of mental maladaptation in relatives of patients with endogenous psychoses,” Zh. Nevrol. Psikhiat., 107, No. 1, 46–51 (2007).

    CAS  Google Scholar 

  3. F. B. Berezin, M. P. Miroshnikov, and R. V. Rozhanets, A Method for the Multidisciplinary Study of Personality in Clinical Medicine and Psychological Hygiene [in Russian], Meditsina, Moscow (1976).

    Google Scholar 

  4. A. V. Kaluev, “BDNF and the serotonin transporter in the pathogenesis of depression (commentaries on the report by Kaufman et al., 2006),” Neironauka, 5, 31–34 (2006).

    Google Scholar 

  5. S. N. Mosolov, Scales for the Psychometric Evaluation of the Symptomatology of Schizophrenia and the Concept of Positive and Negative Disorders [in Russian], Moscow (2001).

  6. T. A. Solokhina, The Quality of Psychiatric Assistance (Organizational and Economic Aspects) [in Russian], Author’s Abstract of Doctoral Thesis in Medical Sciences, Moscow (2003).

  7. B. H. Brummett, S. H. Boyle, I. C. Siegler, et al., “Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR),” Behav. Genet., 38, 34–43 (2008).

    Article  PubMed  Google Scholar 

  8. A. Caspi, K. Sugden, T. E. Moffitt, et al., “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene,” Science, 301, 386–389 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. M. F. Egan, M. Kojima, J. H. Callicott, et al., “The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function,” Cell, 112, 257–269 (2003).

    Article  PubMed  CAS  Google Scholar 

  10. T. C. Eley, K. Sugden, A. Corsico, et al., “Gene-environment interaction analysis of serotonin system markers with adolescent depression,” Mol. Psychiat., 9, 908–915 (2004).

    Article  CAS  Google Scholar 

  11. M. Ferriter and N. Huband, “Experiences of parents with a son or daughter suffering from schizophrenia,” J. Psychiat. Ment. Health Nurs., 10, 552–560 (2003).

    Article  CAS  Google Scholar 

  12. I. I. Gottesman, Schizophrenia Genesis: the Origin of Madness, Freeman, New York (1991).

    Google Scholar 

  13. N. Jacobs, G. Kenis, F. Peeters, et al., “Stress-related negative affectivity and genetically altered serotonin transporter function,” Arch. Gen. Psychiat., 63, 989–996 (2006).

    Article  PubMed  CAS  Google Scholar 

  14. J. Jungbauer and M. C. Angermeyer, “Living with a schizophrenic patient: a comparative study of burden as it affects parents and spouses,” Psychiatry, 65, 110–123 (2002).

    PubMed  Google Scholar 

  15. J. Kaufman, B. Yang, H. Douglas-Palumberi, et al., “Social supports and serotonin transporter gene moderate depression in maltreated children,” Proc. Natl. Acad. Sci. USA, 101, 17316–17321 (2004).

    Article  PubMed  CAS  Google Scholar 

  16. J. Kaufman, B. Z. Yang, H. Douglas-Palumberi, et al., “Brain-Derived Neurotrophic Factor-5-HTTLPR gene interactions and environmental modifiers of depression in children,” Biol. Psychiat., 59, 673–680 (2006).

    Article  PubMed  CAS  Google Scholar 

  17. K. S. Kendler, J. W. Kuhn, J. Vittum, et al., “The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication,” Arch. Gen. Psychiat., 62, 529–535 (2005).

    Article  PubMed  CAS  Google Scholar 

  18. J. Kim, R. Stewart, S. Kim, et al., “Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders,” Biol. Psychiat., 62, 423–428 (2007).

    Article  PubMed  CAS  Google Scholar 

  19. H. J. Lee, M. S. Lee, R. H. Kang, et al., “Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder,” Depress. Anxiety, 21, 135–139 (2005).

    Article  PubMed  CAS  Google Scholar 

  20. K. P. Lesch, D. Bengel, A. Heils, et al., “Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region,” Science, 274, 1527–1531 (1996).

    Article  PubMed  CAS  Google Scholar 

  21. K. P. Lesch and R. Moessner, “Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodenegerative disorders?” Biol. Psychiat., 44, 179–192 (1998).

    Article  PubMed  CAS  Google Scholar 

  22. M. Neves-Pereira, E. Mundo, P. Muglia, et al., “The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study,” Am. J. Hum. Genet., 71, 651–655 (2002).

    Article  PubMed  CAS  Google Scholar 

  23. L. Pezawas, A. Mayer-Lindenberg, A. L. Goldman, et al., “Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression,” Mol. Psychiat., 13, 709–716 (2008).

    Article  CAS  Google Scholar 

  24. S. Sen, R. M. Nesse, S. F. Soltenberg, et al., “A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression,” Neuropsychopharmacology, 28, 397–401 (2003).

    Article  PubMed  CAS  Google Scholar 

  25. P. Sklar, S. B. Gabriel, M. G. McInnis, et al., “Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neurotrophic factor,” Mol. Psychiat., 7, 579–593 (2002).

    Article  CAS  Google Scholar 

  26. S. E. Taylor, B. M. Way,W. T. Welch, et al., “Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology,” Biol. Psychiat., 60, 671–676 (2006).

    Article  PubMed  CAS  Google Scholar 

  27. M. Wichers, G. Kenis, N. Jacobs, et al., “The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication,” Am. J. Med. Genet. B. Neuropsychiatr. Genet., 147B, 120–123 (2008).

    Article  PubMed  CAS  Google Scholar 

  28. K. Wilhelm, P. B. Mitchell, H. Niven, et al., “Life events, first depression onset and the serotonin transporter gene,” Brit. J. Psychiat., 188, 210–215 (2006).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Scientific Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia

    M. V. Alfimova, V. E. Golimbet, A. N. Barkhatova, S. A. Golubev & G. I. Korovaitseva

Authors
  1. M. V. Alfimova
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  2. V. E. Golimbet
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  3. A. N. Barkhatova
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  4. S. A. Golubev
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  5. G. I. Korovaitseva
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Corresponding author

Correspondence to V. E. Golimbet.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 109, No. 12, Iss. I, pp. 50–54, December, 2009.

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Alfimova, M.V., Golimbet, V.E., Barkhatova, A.N. et al. The Role of Genotype-Environment Interactions in the Development of Symptoms of Anxiety and Depression in Stress Associated with Disease in a Family Member. Neurosci Behav Physi 41, 277–282 (2011). https://doi.org/10.1007/s11055-011-9413-x

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  • DOI: https://doi.org/10.1007/s11055-011-9413-x

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