Spike activity from neurons in hippocampal field CA1 and CA3 was compared in rats avoiding (“altruists,” group A) and not avoiding (“egoists,” group E) the cries of a “victim” partner on testing using the emotional resonance method. Neuron discharge frequencies were compared in animals in the state of starvation, after satiation, and on exposure to emotionally positive and negative intracerebral electrical stimuli. These studies showed that hippocampal field CA1 was dominated by cells increasing their spike frequencies after satisfaction of the food motivation, while in field CA3, conversely, most cells decreased activity after eating. Exposure to emotionally significant stimuli identified interhemisphere differences in the activities of hippocampal neurons which were associated with the typological characteristics of the animals. In rats of group A, neurons in field CA1 were activated only in the left hippocampus, while the activity of cells in the right hippocampus was no different from that in baseline conditions. Field CA3 of rats of this group showed no asymmetry. In rats of group E, conversely, lateralization of activity was seen only in field CA3: discharge frequencies were significantly greater in the left hippocampus.
Similar content being viewed by others
References
V. L. Bianki, Brain Asymmetry in Animals [in Russian], Nauka, Leningrad (1985).
V. L. Bianki, Mechanisms of the Paired Brain [in Russian], Nauka, Leningrad (1989).
V. L. Bianki, E. B. Filippova, and S. E. Murik, “Interhemisphere asymmetry of ‘emotional resonance’ in rats,” Zh. Vyssh. Nerv. Deyat., 35, No. 2, 261–273 (1985).
O. S. Vinogradova, The Hippocampus and Memory [in Russian], Nauka, Moscow (1975).
V. A. Geodakyan, “Evolution of the theory of functional asymmetry of the brain,” Dokl. Ros. Akad. Nauk., 324, No. 6, 1323–1326 (1992).
V. A. Geodakyan, “Asynchronous asymmetry,” Zh. Vyssh. Nerv. Deyat., 43, No. 3, 543–561 (1993).
M. I. Zaichenko, N. G. Mikhailova, and Yu. V. Raigorodskii, “Reactions of neurons in the emotional zones of the hypothalamus in emotional stimulus of different signs,” Zh. Vyssh. Nerv. Deyat., 45, No. 2, 367–377 (1995).
M. I. Zaichenko, N. G. Mikhailova, and Yu. V. Raigorodskii, “Hypothalamic neurons and zoosocial interactions,” Zh. Vyssh. Nerv. Deyat., 46, No. 3, 539–547 (1996).
M. I. Zaichenko, N. G. Mikhailova, and Yu. V. Raigorodskii, “Activity of neurons in the prefrontal cortex of the brains of rats with different typological characteristics in emotional stimulations,” Zh. Vyssh. Nerv. Deyat., 50, No. 3, 492–499 (2000).
M. M. Kozlovskaya and A. V. Valdman, “Studies of the actions of psychotropic substances on the septohypothalamic regulation of emotional behavior,” in: Neuropharmacology of Central Regulatory Processes [in Russian], Nauka, Leningrad (1969).
N. G. Mikhailova, M. I. Zaichenko, and Yu. V. Raigorodskii, “Organization of functional interhemisphere asymmetry of the prefrontal cortex in animals of different typological groups,” Zh. Vyssh. Nerv. Deyat., 53, No. 3, 299–306 (2003).
I. V. Pavlov and G. L. Vanetsian, “Activity of neurons in the rabbit neocortex and hippocampus in orientational-investigative behavior and freezing,” Ros. Fiziol. Zh., 92, No. 1, 1263–1284 (2006).
P. V. Simonov, “The need-informational organization of brain activity,” Zh. Vyssh. Nerv. Deyat., 29, No. 3, 467–473 (1979).
P. V. Simonov, The Emotional Brain [in Russian], Nauka, Moscow (1981).
P. V. Simonov, M. L. Pigareva, and V. N. Mats, “Individual characteristics of behavior in rats and brain limbic structures,” Zh. Vyssh. Nerv. Deyat., 32, No. 4, 626–632 (1982).
V. Yu. Urbakh, Biometric Methods [in Russian], Nauka, Moscow (1964).
R. J. Davidson, “Anterior cerebral asymmetry and the nature of emotion,” Brain Cogn., 20, No. 1, 125–151 (1992).
W. Heller, “Neuropsychological mechanisms of individual differences in emotion personality and arousal,” Neuropsychology, 7, No. 4, 476–489 (1993).
J. A. Gray, “A theory of anxiety: the role of the limbic system,” Encephale, 9, No. 4, Supplement 2, 161B–166B (1983).
R. C. Gur, L. Schroeder, T. Turner, C. McGrath, R. M. Chan, B. I. Turetsky, D. Alsop, J. Maldjian, and R. E. Gur, “Brain activation during facial emotion processing,” Neuroimage, 16, No. 3, 651–662 (2002).
M. Lehner, E. Taracha, A. Skorzewska, P. Maciejak, A. Wislowska- Stanek, M. Zienowicz, J. Szyndler, A. Bidzinski, and A. Plaznik, “Behavioral, immunocytochemical and biochemical studies in rats differing in their sensitivity to pain,” Brain Res., 171, No. 2, 189–198 (2006).
N. McNaughton and J. A. Gray, “Anxiolytic action on the behavioral inhibition system implies multiple types of arousal contribute to anxiety,” J. Affect. Disord., 61, No. 3, 161–176 (2000).
W. J. H. Nauta, “An experimental study of the fornix system in the rat,” J. Comp. Neurol., 104, 247–256 (1956).
G. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, New York, London, Paris, San Diego, San Francisco, San Paulo, Tokyo, Toronto (1982).
G. Raisman, “The connections of the septum,” Brain, 89, 317–331 (1966).
H. J. Simmons, “Limbic protections to the anterior nuclei of the thalamus in the squirrel monkey,” Anat. Rec., 169, No. 3, 429 (1971).
T. Verstynen, R. Tierney, T. Urbanski, and A. Tang, “Neonatal novelty exposure modulates hippocampal volumetric asymmetry in the rat,” Neuroreport, 12, No. 14, 3019–3022 (2001).
A. Vyas, R. Mitra, B. S. Shankaranarayana Rao, and S. Chattarji, “Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons,” J. Neurosci., 22, No. 15, 6810–6818 (2002).
S. F. Walker, “Lateralization of functions in the vertebrate brain: a review,” Brit. J. Psychol., 71, No. 3, 329–367 (1980).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 58, No. 4, pp. 467–475, July–August, 2008.
Rights and permissions
About this article
Cite this article
Zaichenko, M.I. Comparative Analysis of Spike Activity of Neurons in Hippocampal Field CA1 and CA3 in Rats of Different Typological Groups on Exposure to Emotional Stimuli. Neurosci Behav Physi 39, 901–908 (2009). https://doi.org/10.1007/s11055-009-9204-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-009-9204-9