Behavioral and neuronal-glial changes after emotional stress induced by discontinuous (7–8 h per day for one week) immobilization were compared in Wistar rats (n = 20). Immobilization led to increases in horizontal and vertical activity and the duration of “comfort” grooming in the open field test. Morphometric measurements demonstrated significant increases in the density of hypoxic neurons in the motor area of the right hemisphere of experimental animals as compared with measures in controls. Hypoxic changes in neurons were functional in nature. Experimental rats can be regarded as a model of the redistribution of brain functional activity with a preferential increase in the role of the left hemisphere.
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References
A. K. Agnaev, “Effects of unilateral cold exclusion of the sensorimotor area of the cat cortex on neuron activity in the symmetrical area,” Zh. Vyssh. Nerv. Deyat., 34, No. 5, 978–979 (1984).
M. G. Airapetyants, “Psychoemotional stress and neurohumoral regulation,” in: Experimental and Applied Physiology. Psychoemotional Stress [in Russian], Nauka, Moscow (1992), Vol. 1, pp. 103–112.
M. G. Airapetyants, “Mechanisms of the pathogenesis of neuroses,” Zh. Vyssh. Nerv. Deyat., 55, No. 6, 734–746 (2005).
A. S. Bazyan, “Modulatory integration as the neurochemical basis of brain integrative processes. Presynaptic mechanisms,” Neirokhimiya, 14, No. 3, 240–247 (1997).
N. Yu. Belenkov, The Integrity Principle in Brain Activity [in Russian], Meditsina, Moscow (1980), pp. 65–76.
V. L. Bianki, Brain Asymmetry in Animals [in Russian], Nauka, Leningrad (1985).
N. N. Bragina and T. A. Dobrokhotova, Functional Asymmetry and the Psychopathology of Focal Brain Lesions [in Russian], Meditsina, Moscow (1977).
M. A. Gilinskii, S. V. Goryakin, T. V. Latysheva, G. M. Petrakova, and N. V. Prokop’eva, “Mechanisms of formation of adaptational traces in fractional stressing,” Byul. Sib. Otdel. Ros. Akad. Med. Nauk, 112, 141–147 (2004).
N. V. Gulyaeva, “Experimental neurosis: free-radical pathology or adaptation to stress?” in: Impairments to Higher Nervous Activity, their Pathogenesis, and Neuropeptide Correction [in Russian], Nauka, Moscow (1992), pp. 14–19.
N. V. Gulyaeva and M. Yu. Stepanichev, “Biochemical correlates of individual-typological characteristics of behavior in rats,” Zh. Vyssh. Nerv. Deyat., 47, No. 2, 329–338 (1997).
K. Konittser, Z. Foigt, M. Poppai, and K. Gekht, “Regional metabolism in the rat brain during stress in hypokinesia,” Zh. Vyssh. Nerv. Deyat., 27, No. 2, 350–351 (1977).
I. P. Levshina and N. V. Gulyaeva, “Relationship between the effects of acute stress on the lateralization of lipid peroxidation products in the brain and the typological characteristics of behavior in rats,” Byull. Éksperim. Biol. Med., 106, No. 6, 568–570 (1991).
I. P. Levshina, N. V. Pasikova, and N. N. Shuikin, “Acquisition of conditioned avoidance reactions and the morphometric characteristics of the sensorimotor cortex in rats subjected to deprivation in early ontogenesis,” Zh. Vyssh. Nerv. Deyat., 55, No. 4, 558–566 (2005).
K. Lorentz, Behind the Mirror [Russian translation], Respublika, Moscow (1996), p. 21.
V. N. Mats, Neuron-Glial Interactions in the Rat Neocortex during Learning [in Russian], Nauka, Moscow (1994).
I. P. Pavlov, The Freedom Reflex [in Russian], Complete Collected Works, Academy of Sciences of the USSR Press, Moscow, Leningrad (1951), Vol. 3, Book 1, pp. 340–345.
M. Poppai, K. Gekht, and L. Morits, “Integrative activity of the brain and blood pressure in rats during hypokinetic stress,” Zh. Vyssh. Nerv. Deyat., 27, No. 2, 348–349 (1977).
P. V. Simonov, The Emotional Brain. Physiology. Neuroanatomy. The Psychology of Emotions. Brain: Emotions, Needs, Behavior [in Russian], Selected Works, Nauka, Moscow (2004), Vol. 1, p. 142.
P. E. Snesarev, Theoretical Bases of the Pathological Anatomy of Mental Disease [in Russian], Medgiz, Moscow (1950).
E. N. Chuyan and T. V. Zayachnikova, “Modification of pain sensitivity in rats in hypokinetic stress,” Neirofiziologiya, 39, No. 2, 174–183 (2007).
T. Endo and K. Shiraki, “Behavior and body temperature in rats following chronic foot shock or psychological stress exposure,” Physiol. Behav., 71, 263–268 (2000).
K. Fukuhara, R. Kvetnansky, and V. K. Wiese, “Effect of continuous and intermittent cold on sympathoadrenal system activity in rats,” J. Neuroendocrinol., 8, 65–72 (1996).
M. B. Graever, W. F. Blakemore, and G. W. Kreutzberg, Cellular Pathology of the Central Nervous System, D. I. Graham, and P. L. Lantos (eds.), Greenfield’s Neuropathology, Edward Arnold, London (2002), Chapter 3, 7, pp. 123–191.
G. Gurp, V. M. Wiegant, C. A. van Léon and S. Rianne, “Individual reactivity to the open-field predicts the expression of cardiovascular and behavioural sensitisation to novel stress,” Behav. Brain Res., 175, 9–17 (2006).
E. Y. Paxinos and C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego (1997).
F. T. A. Pijlman and J. M. van Ree, “Physical but not emotional stress induces a delay in behavioural coping responses in rats,” Behav. Brain Res., 136, 365–373 (2002).
F. T. A. Pijlman, G. Wolterink, and J. M. van Ree, “Physical and emotional stress have differential effects on preference for saccharine and open field behaviour in rats,” Behav. Brain Res., 139, 131–138 (2003).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 58, No. 4, pp. 500–506, July–August, 2008.
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Levshina, I.P., Mats, V.N., Pasikova, N.V. et al. Comparison of the Behavior of Rats after Immobilization with Structural Changes in the Motor Cortex. Neurosci Behav Physi 39, 915–919 (2009). https://doi.org/10.1007/s11055-009-9202-y
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DOI: https://doi.org/10.1007/s11055-009-9202-y