EEG traces were recorded from the hippocampus and medial septal area of conscious guinea pigs in control conditions and on repeated stimulation of the perforant path. Changes in the correlations of activity in these structures during stimulation-evoked convulsions (a model of acute epilepsy) and during the process of epileptogenesis (a model of chronic epilepsy) were analyzed. A high correlation between baseline activity in the hippocampus and medial septal area seen in control conditions decreased sharply with the appearance of acute and chronic convulsions. Kindling led to hippocampus-independent generation of field convulsive discharges in the medial septal area. During kindling, there was a gradual disintegration of activity in the hippocampus and septum, which provides evidence for impairment of the operation of the septo-hippocampal network during epileptogenesis.
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References
O. V. Godukhin, “Cellular-molecular mechanisms of kindling,” Usp. Fiziol. Nauk., 36, No. 2, 41–54 (2005).
A. Alonso and C. Kohler, “Evidence for separate projections of hippocampal pyramidal and non-pyramidal neurons to different parts of the septum in the rat brain,” Neurosci. Lett., 31, 209–214 (1982).
L. V. Colom, “Septal networks: relevance to theta rhythm, epilepsy and Alzheimer ‘s disease,” J. Neurochem., 96, 609–623 (2006).
T. F. Freund and M. Antal, “GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus,” Nature, 336, 170–173 (1988).
M. Frotscher and C. Leranth, “Cholinergic innervation of the rat hippocampus as revealed by choline acetyl-transferase immunocytochemistry: a combined light and electron microscopic study,” J. Comp. Neurol., 239, 237–246 (1985).
A. Hjorth-Simonsen, and B. Juene, “Origin and termination of the hippocampal perforant path in the rat studies by silver impregnation,” J. Comp. Neurol., 144, 215–224 (1972).
C. Leranth, D. Carpi, G. Buszaki, and J. Kiss, “The entorhino-septo-supramammillary nucleus connection in the rat: morphological basis of a feedback mechanism regulating hippocampal theta rhythm,” Neurosci., 88, 701–718 (1999).
N. McNaughton, M. Ruan, and M.-A. Woodnorth, “Restoring thetalike rhythmicity in rats restores initial learning in the Morris water maze,” Hippocampus, 16, 1102–1110 (2006).
C. Rapiscarda and B. Bacchelli, “The brain of the guinea pig in stereotaxic coordinates,” Arch. Sci. Biol., 61, 1–37 (1977).
P. Y. Risold and L. W. Swanson, “Connections of the rat lateral septal complex,” Brain Res. Rev., 24, No. 2–3, 115–195 (1997).
M. Sato, T. Onishi, T. Nakashima, and S. Otsuki, “Experimental study on epilepsy using a ‘kindling preparation’. Correlation between septal seizure development and psychomotor seizure,” No To Sinkey, 28, No. 7, 667–679 (1976).
K. Toth, Z. Borhegyi, and T. F. Freund, “Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of Broca complex,” J. Neurosci., 13, 3712–3724 (1993).
K. Toth, T. F. Freund, and R. Miles, “Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum,” J. Physiol. (England), 500, 463–474 (1997).
R. P. Vertes and B. Kocsis, “Brainstem-diencephalo-septo-hippocampal system controlling the theta rhythm of the hippocampus,” Neurosci., 81, 893–926 (1997).
O. S. Vinogradova, “Expression, control and probable functional significance of the neuronal theta rhythm,” Progr. Neurobiol., 45, 523–583 (1995).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 58, No. 3, pp. 345–350, May–June, 2008.
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Sinel’nikova, V.V., Popova, I.Y. & Kichigina, V.F. Correlational Relationships Between the Hippocampus and Medial Septal Area and Their Changes During Epileptogenesis. Neurosci Behav Physi 39, 619–623 (2009). https://doi.org/10.1007/s11055-009-9189-4
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DOI: https://doi.org/10.1007/s11055-009-9189-4