A total of 60 patients aged 6–16 years with tics and Tourette’s syndrome were studied. Antibodies to caudate nucleus proteins were assayed by western blot hybridization. Ten patients with Tourette’s syndrome were found to have antibodies to caudate nucleus protein. Seven patients with neuroleptic-resistant types of Tourette’s syndrome received single transfusions of immunoglobulin preparations, which produced regression of vocal and motor hyperkinesias and improvement in behavior (remission for more than six months). The observation of antibodies to caudate nucleus proteins and the positive effects seen on administration of immunoglobulins to patients with Tourette’s syndrome support previous data on the possibility of using immunoglobulin therapy in the treatment of tic-type hyperkinesias and provide evidence of the involvement of autoimmune mechanisms inducing damage to the dopaminergic system of the striatum.
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References
V. V. Abramov, Integration of the Immune and Nervous Systems [in Russian], Nauka, Novosibirsk (1991), p. 168.
I. G. Akmaev, “Interaction of the nervous and endocrine systems and immune mechanisms of the brain,” Nevropatol. Psikhiat., 3, 54–56 (1998).
P. D. Gorizontov, O. P. Belousova, and M. I. Fedotova, Stress and the Blood System [in Russian], Meditsina, Moscow (1983), p. 224.
G. N. Kryzhanovskii, S. V. Magaeva, and S. V. Makarov, Neuroimmunology [in Russian], Moscow (1997), p. 282.
V. A. Levando, R. S. Suzdal’skii, G. N. Kassil’, et al., “Stress immunodeficiencies in humans,” Usp. Fiziol. Nauk., 3, 79–97 (1990).
M. Eibl, Intravenous Immunoglobulin Research and Therapy, The Parthenon Publishing Group, London (1996), pp. 659–676.
J. J. Hallet, C. J. Harling-Berg, P. M. Knopf, et al., “Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction,” J. Neuroimmunol., 111, No. 1–2, 195–202 (2000).
H. L. Leonard and S. E. Swedo, “Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS),” Int. J. Neuropsychopharmacol., 4, No. 2, 191–198 (2001).
C. R. Loiselle, Q. Lee, T. H. Moran, and H. S. Singer, “Striatal microinfusion of Tourette syndrome and PANDAS sera: failure to induce behavioral changes,” Mov. Disord., 19, No. 4, 390–396 (2004).
N. Muller, M. Riedel, A. Erfurth, and H. J. Moller, “Immunoglobulin therapy in Gilles de la Tourette syndrome,” Nervenarzt, 68, No. 11, 914–916 (1997).
S. J. Perlmutter, S. F. Leitman, M. A. Garvey, et al., “Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorders and tic disorders in childhood,” Lancet, 354, No. 9185, 1153–1158 (1999).
H. S. Singer, J. D. Giuliano, B. H. Hausen, et al., “Antibodies against human putamen in children with Tourette syndrome,” Neurology, 50, No. 6, 1618–1624 (1998).
H. S. Singer, C. R. Loiselle, O. Lee, et al., “Anti-Basal Ganglia Antibodies in PANDAS,” Mov. Disord., 19, No. 4, 406–415 (2004).
K. Visvanathan, R. R. Trifiletti, M. Altemus, and J. B. Zabriskie, “Autoimmune mechanisms in movement disorders,” Semin. Pediat. Neurol., 7, No. 2, 103–107 (2000).
A. Zameer and S. A. Hoffman, “Increased ICAM-1 and VCAM-1 expression in the brains of autoimmune mice,” J. Neuroimmunol., 142, 67–74 (2003).
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 108, No. 8, pp. 10–13, August, 2008.
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Zykov, V.P., Shcherbina, A.Y., Novikova, E.B. et al. Neuroimmune Aspects of the Pathogenesis of Tourette’s Syndrome and Experience in the Use of Immunoglobulins in Children. Neurosci Behav Physi 39, 635–638 (2009). https://doi.org/10.1007/s11055-009-9184-9
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DOI: https://doi.org/10.1007/s11055-009-9184-9