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The state of cerebral hemodynamics in conditions of prolonged adaptation to hypercapnic hypoxia

Neuroscience and Behavioral Physiology volume 39, pages 269–273 (2009)Cite this article

Intermittent hypercapnic hypoxia was accompanied by increases in cerebral vascular resistance, decreases in the reactivity of cerebral vessels to hypercapnia, and increases in the collateral reserve and rate of autoregulation of brain blood flow. These changes were an important component of the mechanism increasing the tolerance of the brain to ischemia in response to training with hypercapnic hypoxia.

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References

  1. I. A. Aleshin, A. N. Tin'kov, Ya. I. Kots, and V. P. Tverdokhlib, “Experience in the treatment of patients with cardiovascular diseases by adaptation to periodic barochamber hypoxia,” Ter. Arkhiv, No. 1, 54–58 (1997).

    Google Scholar 

  2. I. S. Breslav and V. D. Glebovskii, The Control of Respiration [in Russian], Nauka, Leningrad (1981).

    Google Scholar 

  3. G. I. Kositskii, Preventative Cardiology [in Russian], Meditsina, Moscow (1987).

    Google Scholar 

  4. V. P. Kulikov and A. G. Bespalov, “An apparatus for producing hypoxic hypercapnia,” Ékhografiya, 3, No. 2, 160–164 (2002).

    Google Scholar 

  5. V. P. Kulikov, “Pathophysiology of impairments to regional hemodynamics and methods for diagnosis and correction,” Sib. Med. Zh., No. 3, 93–103 (2004).

    Google Scholar 

  6. G. I. Kuntsevich, Cerebral Atherosclerosis. Evolution of Concepts and Therapeutic Conclusions [in Russian], Moscow (1998).

  7. N. A. Lassen and P. Johnson, The Brain. Peripheral blood Supply [Russian translation], Moscow (1982).

  8. Yu. I. Luchakov and K. P. Ivanov, “Brain tissue oxygen supply at decreased oxygen tension in arterial capillary blood,” Fiziol. Zh. SSSR im. I. M. Sechenova, No. 2, 66–72 (1991).

  9. E. I. Maevskii, E. V. Trishina, A. S. Rozenfel'd, A. M. Zyakun, I. M. Vereshchagina, and M. N. Kondrashova, Ros. Biomed. Zh., 1, No. 3, 32–36 (2000).

    Google Scholar 

  10. A. I. Matyushin, “Estrogens and myocardial infarcts,” Patol. Fiziol. Éksperim. Ter., No. 3, 32–35 (2001).

  11. F. Z. Meerson, Adaptational Medicine: Mechanisms and Protective Effects of Adaptation [in Russian], Hypoxia Medical, Moscow (1993).

    Google Scholar 

  12. Yu. E. Moskalenko, A. I. Beketov, and R. S. Orlov, Brain Circulation [in Russian], Leningrad (1981).

  13. V. S. Novikov, S. I. Lustin, and A. N. Zhekalov, “Use of hypobaric hypoxia in the treatment of patients with neurocirculatory dystonia of the hypertensive type,” Voenno-Med. Zh., No. 12, 16–20 (1997).

  14. M. M. Odinak, I. A. Voznyuk, and A. P. Novozhilova, “Common pathogenetic variants of the development of acute cerebral hemodynamic impairments,” Vestn. Ros. Voen.-Med. Akad., No. 1, 107–109 (1999).

    Google Scholar 

  15. M. G. Pshennikova, L. Yu. Golubeva, and B. A. Kuznetsova, “Differences in stress reactions and the formation of adaptation to stress in August and Wistar rats,” Byull. Éksperim. Biol. Med., No. 8, 156–159 (1996).

    Google Scholar 

  16. V. B. Semenyutin and D. V. Svistov, “Regulation of brain blood flow and ultrasound methods for its assessment,” in: Doppler Ultrasound Diagnosis in Clinical Practice [in Russian], Yu. M. Nikitin and A. I. Ivanovo (eds.), MIK Press, Moscow (2004).

    Google Scholar 

  17. V. C. Sverchkova and E. E. Zver'kova, “Myocardial blood supply on training with hypoxic-hypercapnic methods,” in: Regulatory Mechanisms in Hemodynamics [in Russian], Alma-Ata (1983).

  18. B. Volkov and É. Neal, Circulation [Russian translation], Moscow.

  19. D. S. Holden and D. G. Priestley, Respiration [Russian translation], Leningrad (1937).

  20. Yu. L. Shevchenko, Hypoxia. Adaptation, Pathogenesis, Clinical Features. Handbook for Physicians [in Russian], OOO ELBI-SPb, St. Petersburg (2000).

    Google Scholar 

  21. E. V. Shmidt, D. K. Lunev, and N. V. Vereshchagin, Vascular Diseases of the Brain [in Russian], Meditsina, Moscow (1976).

    Google Scholar 

  22. R. Aaslid, D. W. Newell, R. Stooss, W. Sorteberg, and K. F. Lindegaard, “Assessment of cerebral autoregulation dynamics from simultaneous arterial and venous transcranial Doppler recordings in humans,” Stroke, 22, No. 9, 1148–1154 (1991).

    PubMed  CAS  Google Scholar 

  23. V. Babikian and L. Wechsler, Transcranial Doppler Ultrasonography, Mosby-Year Book, Inc. (1993).

  24. A. Y. Estevez and J. W. Phillis, “Hypercapnia-induced increased in cerebral blood flow: Roles of adenosine, nitric oxide and cortical arousal,” Brain Res., No. 1–2, 1–8 (1997).

  25. C. Ladecola and X. Xu, “Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism,” Amer. J. Physiol., No. 2, 518–525 (1994).

  26. X. Leverve, “Metabolic and nutritional consequences of chronic hypoxia,” Clin. Nutr., No. 6, 241–251 (1998).

    Google Scholar 

  27. L. Pourselot, “Applications cliniques de l'examen Doppler transcutane,” in: Velocimetrie Ultrasonore Doppler, P. Peronneau (ed.), INSERM, Paris (1974), pp. 780–785.

    Google Scholar 

  28. W. B. Stewart, L. Ment, and M. Schwartz, “Chronic postnatal hypoxia increases the numbers of cortical neurons,” Brain Res., No. 2, 17–21 (1995).

    Google Scholar 

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Affiliations

  1. Federal Agency for Health and Social Development, Altai State Medical University, 40 Lenin Prospekt, Barnaul, 656038, Altai Region, Russia

    V. P. Kulikov, A. G. Bespalov & N. N. Yakushev

  2. Altai Branch, State Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 40 Lenin Prospekt, Barnaul, 656038, Altai Region, Russia

    V. P. Kulikov, A. G. Bespalov & N. N. Yakushev

Authors
  1. V. P. Kulikov
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  2. A. G. Bespalov
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  3. N. N. Yakushev
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Correspondence to V. P. Kulikov.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 94, No. 2, pp. 191–197, February, 2008.

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Kulikov, V.P., Bespalov, A.G. & Yakushev, N.N. The state of cerebral hemodynamics in conditions of prolonged adaptation to hypercapnic hypoxia. Neurosci Behav Physi 39, 269–273 (2009). https://doi.org/10.1007/s11055-009-9121-y

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  • DOI: https://doi.org/10.1007/s11055-009-9121-y

KEY WORDS

  • hypoxia
  • hypercapnia
  • cerebral hemodynamics
  • adaptation