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Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride

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Morphological changes in neurons and the distributions of nerve and glial cells were studied, the glial index was calculated, and manganese (Mn) contents were determined in the caudate nucleus, the nucleus accumbens, the dorsal and ventral septal nuclei, and the frontoparietal areas of the cerebral cortex in the 40-day-old offspring of rats given different doses (10 and 20 mg/kg) of manganese chloride (MnCl2·4H2O) 15–20 days before pregnancy, during pregnancy, and for one month after parturitiion with the first portion of food. Mn poisoning increased Mn contents in the brains of rat pups, damaged a small proportion of neurons, and produced marked gliosis. These changes are believed to underlie previously described impairments to learning processes and emotional state in rat pups.

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Authors and Affiliations

  1. Laboratory for Functional Neuroanatomy (Director: Professor I. L. Lazrishvili), I. S. Beritashvili Institute of Physiology, Tbilisi, Georgia

    I. L. Lazrishvili (Lazriev) & T. Z. Bikashvili

  2. Department of Human Anatomy (Director: Academician of the Georgian Academy of Medical Sciences Professor R. G. Khetsuriani), Tbilisi State Medical University, Tbilisi, Georgia

    A. A. Shukakidze

  3. Department of Biology (Director: Master of Biological Sciences Sh. R. Dzhindzholiya), A. Tsereteli Kutaisi State University, Kutaisi, Georgia

    N. N. Chkhartishvili

Authors
  1. I. L. Lazrishvili (Lazriev)
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  2. A. A. Shukakidze
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  3. N. N. Chkhartishvili
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  4. T. Z. Bikashvili
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Correspondence to I. L. Lazrishvili (Lazriev).

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Translated from Morfologiya, Vol. 133, No. 1, pp. 25–30, January–February, 2008.

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Lazrishvili (Lazriev), I.L., Shukakidze, A.A., Chkhartishvili, N.N. et al. Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride. Neurosci Behav Physi 39, 7–12 (2009). https://doi.org/10.1007/s11055-008-9092-4

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  • DOI: https://doi.org/10.1007/s11055-008-9092-4

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