Abstract
Studies of identical groups of male Wistar rats after preliminary selection to give groups including extreme behavioral types with low and high rankings on the anxiety scale showed that blood testosterone concentrations in intact rats (controls) correlated negatively with anxiety ranking, i.e., minimal hormone concentrations (no greater than 5 nM) corresponded to high levels of anxiety — with a predominance of passive defensive behavioral components on testing. Short-term exposure to a “death threat” situation (sight of a boa attacking and eating two individuals from the group of rats) impaired this correlational relationship in a manner comparable to the sequelae of chronic neuroticization by unavoidable pain stimulation. Impairments were manifest as scatter in measures in low-anxiety animals (3–21 nM). This characteristic, reflecting the multitude of adaptive pathways in the population in threat situations, distinguishes this type of action from neuroticization by unavoidable pain stimulation, which leveled out individual differences and decreased the hormone level.
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References
M. G. Airapetyants, N. M. Khonicheva, and A. Ya. Mekhedova, “Seeking activity and the resistance of the body to extreme influences,” in: Selling Activity, Motivation, and Sleep [in Russian], Baku (1998), pp. 4–15.
M. G. Airapetyants, A. A. Yakovleva, I. P. Levshina, O. N. Vorontsova, M. Yu. Stepanichev, M. V. Onufriev, N. A. Lazareva, and N. V. Gulyaeva, “Studies of the mechanisms mediating neuron death in chronic stress,” Neirokhimiya, 23, No. 2, 136–142 (2006).
D. A. Zhukov, The Psychogenetics of Stress [in Russian], St. Petersburg (1997).
N. A. Krupina, I. N. Orlov, G. N. Kryzhanovskii, and A. D. Solov'ev, “Studies of the sensorimotor reactivity of rats with high levels of anxiety-phobia,” Zh. Vyssh. Nerv. Deyat., 44, No. 6, 1097–1105 (1994).
A. Leonova and D. Kostikov, At the Margins of Stress, V Mire Nauki, No. 10, 63–71 (2004).
N. É. Ordyan, A. I. Vaido, V. V. Rakitskaya, F. I. Proimina, N. V. Shiryaeva, N. G. Lopatin, and V. G. Shalyapina, “Functioning of the hypophyseal-adrenocortical system in rats bred for the threshold of sensitivity to electrical currents,” Byull. Éksperim. Biol. Med., 124, No. 4, 443–445 (1998).
S. G. Pivina, V. K. Akulova, and N. É. Ordyan, “Characteristics of the behavior and stress reactivity of the hypophyseal-adrenocortical system in rats with prenatal derangements to testosterone metabolism,” Ros. Fiziol. Zh., 91, No. 9, 1071–1079 (2005).
N. N. Pukhovskii, Psychopathological Sequelae of Extreme Situations [in Russian], Novyi Prospekt, Moscow (2000).
V. I. Rodina, N. A. Krupina, G. N. Kryzhanovskii, and N. V. Oknina, “A multiparametric method for the complex treatment of anxious-phobic states in rats,” Zh. Vyssh. Nerv. Deyat., 43, No. 5, 1007–1017 (1993).
P. V. Simonov, Conditioned Emotional Resonance Reactions in Rats. A Neurophysiological Approach to the Analysis of Intraspecies Behavior [in Russian], Nauka, Moscow (1976).
L. V. Tarasenko, V. A. Reznikov, and A. V. Mikhnev, “On the question of seasonal variations in the androgen functions of the testicles in rats,” Fiziol. Zh., 35, No. 2, 107–109 (1989).
N. M. Khonicheva and M. A. Bulgakova, “Autonomic reactions on administration of atropine and propranolol in rats with different types of behavior,” Zh. Vyssh. Nerv. Deyat., 32, No. 3, 433–441 (1982).
S. G. Tsikunov, T. M. Makarova, A. G. Kusov, and V. V. Shabaev, “The effects of ‘pure’ psychogenic trauma on the structure of emotional behavior in rats,” in: Current Questions in Studies in Physiology and Medicine [in Russian], Nauka, St. Petersburg (2000).
V. G. Shalyapina, A. I. Vaido, N. G. Lopatina, N. É. Ordyan, V. V. Rakitskaya, O. N. Savchenko, and N. V. Shiryaeva, “Changes in sex steroid hormone secretion in stress in rats with different brain excitabilities,” Fiziol. Zh., 85, No. 11, 1428–1433 (1999).
M. L. Andersen, M. Bignotto, R. B. Machado, and S. Tufik, “Different stress modalities result in distinct steroid hormone responses by malt rats,” Brazil J. Med. Biol. Res., 37, 791–797 (2004).
A. E. Calogerro, J. Bagdy, and R. A. Agata, “Mechanism of stress on reproduction: evidence for complex intrahypothalamic circuit,” Ann. N.Y. Acad. Sci., 851, 364–371 (1998).
G. P. Chrousos and P. W. Gold, “The concepts of stress system disorders,” JAMA, 267, 1244–1252 (1992).
A. Lopez-Calderon, C. Ariznavarreta, J. A. Gonzalez-Quijano, and M. D. Calderon, “Stress induced changes in testis function,” J. Steroid Biochem. Mol. Biol., 40, 473–479 (1991).
N. M. Khonicheva, M. Yu. Stepanichev, S. G. Tsikunov, M. V. Onufriev, Yu. A. Moiseeva, N. A. Lazareva, R. Czabak-Garbach, N. V. Gulyaeva, and M. G. Airapetyants, “First preliminary response of hippocampus on two models of psychical stress in rat,” in: Hippocampus and Memory, Pushchino-na-Oke (2006), p. 89.
A. Ya. Mechedova, K. Hect, K. Treptow, and T. Hecht, “Zur Rolle der Unbestimmtheit im bedingt-reflektorischen “Lernverhalten für ausgewählte Herz-Kreislauffunktionen,” Acta Biol. Med. Germ., 35, 867–879 (1976).
D. Rabin, P. Gold, A. N. Varcioris, P. J. Schmidt, and G. P. Chrousos, “Stress and reproduction: physiological and pathophysiological interaction between the stress and reproductive axes,” Adv. Exptl. Med. Biol., 245, 377–387 (1988).
C. Rivier, J. Rivier, and W. Vale, “Stress-induced inhibition of reproductive function: role of endogenic corticotrophin-releasing factor,” Science, 231, 607–609 (1986).
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 57, No. 5, pp. 591–597, September–October, 2007.
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Khonicheva, N.M., Livanova, L.M., Tsykunov, S.G. et al. Blood testosterone in rats: Correlation of the level of individual anxiety and its impairment after “death threat”. Neurosci Behav Physi 38, 985–989 (2008). https://doi.org/10.1007/s11055-008-9081-7
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DOI: https://doi.org/10.1007/s11055-008-9081-7