Abstract
The aim of the present work was to perform a morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. Chronic ischemia was produced in Wistar rats (weighing 160–180 g) by ligation of both common carotid arteries. Ischemic lesions were corrected by intragastric lanthanum acetate (3 mg/kg per day) throughout the experimental period. Ischemic damage to the cortex was assessed morphometrically on histological sections stained by the Nissl method. Lanthanum acetate was found to suppress the development of ischemic neuron damage in the cerebral cortex, with reductions in the numbers of hyperchromic neurons, cells with focal chromatolysis, and ghost cells, as well as an increase in the number of normochromic cells as compared with controls.
Similar content being viewed by others
References
N. D. Avtandilov, Medical Morphometry [in Russian], Meditsina, Moscow (1990).
O. A. Berkhova and V. R. Soroka, “The biological role of lanthanides,” Usp. Sovrem. Biol., 90, No. 3 (6), 365–381 (1980).
E. I. Gusev and V. I. Skvortsova, Brain Ischemia [in Russian], Meditsina, Moscow (2001).
G. F. Lakin, Biometry [in Russian], Meditsina, Moscow (1990).
Microscope Technology: A Handbook for Doctors and Laboratory Staff [in Russian], Meditsina, Moscow (1996).
M. B. Plotnikov and O. E. Vaizova, “Comparative analysis of two models of chronic cerebral ischemia in the rat,” Pat. Fiziol., No. 2, 59–60 (1994).
M. B. Plotnikov, S. V. Logvinov, N. V. Pugachenko, et al., “The cerebroprotective effects of a mixture of diquercetin and ascorbic acid,” Byull. Éksperim. Biol., 130, No. 11, 543–547 (2000).
T. M. Plotnikova, T. G. Bazhenova, M. B. Plotnikova, and A. S. Saratikov, “Effects of cerebrocrast on the microcirculation in acute transient cerebral ischemia,” Eksper. Klin. Farmakol., 58, No. 2, 27–29 (1995).
P. E. Bickler and B. M. Hansen, “Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage,” Brain Res., 665, No. 2, 269–276 (1994).
T. Das, A. Sharma, and G. Talucder, “Effects of lanthanum in cellular systems,” Biol. Trace Elem. Res., No. 18, 201–228 (1988).
C. H. Evans, “Interesting and useful biochemical properties of lanthanides,” Trends Biochem. Sci., No. 8, 445–449 (1983).
J. H. Greenberg, D. Uematsu, N. Araki, and W. F. Hickey, “Cytosolic free calcium during focal cerebral ischemia and effects of nimodipine on calcium and histologic damage,” Stroke, 72, Supplement 4, 78 (1990).
J. Horn, R. J. de Haan, M. Vermeulen, et al., “Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review,” Stroke, 32, No. 10, 2433–2438 (2001).
T. Kristian and B. K. Siesjo, “Calcium-related damage in ischemia,” Life Sci., No. 59, 357–367 (1996).
Author information
Authors and Affiliations
Additional information
__________
Translated from Morfologiya, Vol. 132, No. 4, pp. 24–27, July–August, 2007.
Rights and permissions
About this article
Cite this article
Gulyaev, S.M., Ubasheev, I.O. & Kozhevnikova, N.M. Morphological assessment of the cerebroprotective action of lanthanum acetate in chronic cerebral ischemia in rats. Neurosci Behav Physi 38, 747–750 (2008). https://doi.org/10.1007/s11055-008-9041-2
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-008-9041-2