Relationship between dopamine system genes and extraversion and novelty seeking
- 887 Downloads
Dopamine transmission is known to play an important role in the reinforcement system of the brain. Studies have identified dopamine system genes whose polymorphic variants have been linked with the intensity of psychological traits reflecting the tendency to form behaviors characterized by impulsivity and the need for additional stimulation. The aim of the present work was to seek associations between polymorphisms in the catechol-O-methyltransferase (COMT) and D4 dopamine receptor (DRD4) genes and personality traits in the Russian population. Studies of 130 subjects showed that carriers of the Met/Met genotype of the COMT gene had a greater intensity of the novelty-seeking trait than carriers of the Val/Val and Val/Met genotypes, though this association was seen only in women. In addition, the presence of the C allele of the DRD4 gene in carriers of the Met/Met genotype showed high levels of extraversion and hypomania. These results are consistent with current theoretical concepts of the regulation of dopamine transmission in the brain.
Key wordsdopamine reinforcement system gene polymorphism novelty-seeking extraversion dopamine receptor catechol-O-methyltransferase
Unable to display preview. Download preview PDF.
- 4.J. Chen, B. K. Lipska, N. Halim, Q. D. Ma, M. Matsumoto, S. Melhem, B. S. Kolachana, T. M. Hyde, M. M. Herman, J. Apud, M. F. Egan, J. E. Kleinman, and D. R. Weinberger, “Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain,” Amer. J. Hum. Genet., 75, No. 5, 807–821 (2004).PubMedCrossRefGoogle Scholar
- 5.R. P. Ebstein, O. Novick, R. Umansky, B. Priel, Y. Osher, D. Blaine, E. R. Bennett, L. Nemanov, M. Katz, and R. H. Belmaker, “Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking,” Nat. Genet., 12, No. 1, 78–80 (1996).PubMedCrossRefGoogle Scholar
- 10.H. J. Lachman, K. A. Nolan, P. Mohr, T. Saito, and J. Volavka, “Association between catechol O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder,” Amer. J. Psychiatry, 155, 835–837 (1998).Google Scholar
- 11.H. J. Lee, H. S. Lee, Y. K. Kim, S. H. Kim, L. Kim, M. S. Lee, S. H. Joe, I. K. Jung, K. Y. Suh, and S. Kim, “Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population,” Amer. J. Med. Genet., 118B, No. 1, 76–80 (2003).CrossRefGoogle Scholar
- 14.M. Matsumoto, C. S. Weickert, S. Beltaifa, B. Kolachana, J. Chen, T. M. Hyde, M. M. Herman, D. R. Weinberger, and J. E. Kleinman, “Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia,” Neuropsychopharmacology, 28, No. 8, 1521–1530 (2003).PubMedCrossRefGoogle Scholar
- 16.K. A. Nolan, J. Volavka, P. Czobor, A. Cseh, H. Lachman, T. Saito, J. Tiihonen, A. Putkonen, T. Hallikainen, I. Kotilainen, P. Rasanen, M. Isohanni, M. R. Jarvelin, and M. K. Karvonen, “Suicidal behavior in patients with schizophrenia is related to COMT polymorphism,” Psychiatr. Genet., 10, 117–124 (2000).PubMedCrossRefGoogle Scholar
- 21.A. Rotondo, C. Mazzanti, L. Dell-Osso, P. Rucci, P. Sullivan, S. Bouanani, C. Gonnelli, D. Goldman, and G. B. Cassano, “Catechol-O-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder,” Amer. J. Psychiatry, 159, 23–29 (2002).CrossRefGoogle Scholar
- 22.M. Rubinstein, T. J. Phillips, J. R. Bunzow, T. L. Falzone, G. Dziewczapolski, G. Zhang, Y. Fang, J. L. Larson, J. A. McDougall, J. A. Chester, C. Saez, T. A. Pugsley, O. Gershanik, M. J. Low, and D. K. Grundy, “Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine,” Cell, 90, 991–1001 (1997).PubMedCrossRefGoogle Scholar
- 26.S. Shifman, M. Bronstein, M. Sternfeld, A. Pisante-Shalom, E. Lev-Lehman, A. Weizman, I. Reznik, B. Spivak, N. Grisaru, L. Karp, R. Schiffer, M. Kotler, R. D. Strous, M. Swartz-Vanetik, H.Y. Knobler, E. Shinar, J. S. Beckmann, B. Yakir, N. Risch, N. B. Zak, and A. Darvasi, “A highly significant association between a COMT haplotype and schizophrenia,” Amer. J. Hum. Genet., 71, No. 6, 1296–1302 (2002).PubMedCrossRefGoogle Scholar