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Age-related characteristics of the neurotransmitter composition of neurons in the stellate ganglion

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Abstract

The neurotransmitter composition of neurons in the stellate ganglion of rats of different ages (neonatal, 10, 20, 30, and 60 days) was studied by an immunocytochemical method using double labeling. Most neurons in rat pups of all age groups contained tyrosine hydroxylase. Most choline acetyltransferase-positive neurocytes in neonatal and 10-day-old rat pups were also tyrosine hydroxylase-positive. Only occasional cells in 30-and 60-day rat pups contained both of these enzymes. There were increases in the proportions of cells containing tyrosine hydroxylase and neuropeptide Y from birth to all time points of the study. In addition, there was a decrease in the proportion of somatostatin-positive neurons. The proportions of VIP-positive cells and choline acetyltransferase-containing neurons increased to age 10 days and then decreased. Somatostatin-positive neurons in all rat pups were small cells, while those containing choline acetyltransferase were large. Maturation of the neurotransmitter set in the rat stellate ganglion was complete by the end of the second month of life.

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References

  1. A. D. Nozdrachev, “The chemical structure of a peripheral autonomic (visceral) reflex,” Usp. Fiziol. Nauk., 27, No. 2, 28–60 (1996).

    PubMed  CAS  Google Scholar 

  2. A. D. Nozdrachev and A. V. Yantsev, Autonomic Transmission [in Russian], St. Petersburg (1995).

  3. A. D. Nozdrachev and M. M. Fateev, The Stellate Ganglion. Structure and Function [in Russian], St. Petersburg (2002).

  4. V. S. Sheveleva, Evolution of the Functions of the Sympathetic Ganglia in Ontogenesis [in Russian], Leningrad (1977).

  5. A. G. M. Bullock, “Somatostatin enhances neurite outgrowth and electrical coupling of regenerating neurons in Helisoma,” Brain Res., 412, 6–17 (1987).

    Article  Google Scholar 

  6. P. Cochard, M. Goldstein, and I. B. Black, “Initial development of the noradrenergic phenotype in autonomic neuroblasts of the rat embryo in vivo,” Dev. Biol., 71, 109–114 (1979).

    Article  Google Scholar 

  7. H. H. Dale and W. Feldberg, “The chemical transmission of secretory impulses to the sweat glands of the cat,” J. Physiol., 82, 121–128 (1934).

    PubMed  CAS  Google Scholar 

  8. U. Ernsberger, “The development of postganglionic sympathetic neurons: coordinating neuronal differentiation and diversification,” Auton. Neurosci. Basic Clin., 94, 1–13 (2001).

    Article  CAS  Google Scholar 

  9. U. Ernsberger and H. Rohrer, “Development of the cholinergic neurotransmitter phenotype in postganglionic sympathetic neurons,” Cell Tiss. Res., 297, 339–361 (1999).

    Article  CAS  Google Scholar 

  10. U. S. von Euler, “A specific sympathomimetic ergone in sympathetic nerve fibers (sympathin) and its relation to adrenaline and noradrenaline,” Acta Physiol. Scand., 12, 73–97 (1946).

    Google Scholar 

  11. J. B. Furness, J. L. Morris, I. L. Gibbins, and M. Costa, “Chemical coding of neurons and plurichemical transmission,” Ann. Rev. Pharmacol. Toxicol., 29, 289–306 (1989).

    Article  CAS  Google Scholar 

  12. I. L. Gibbins, “Vasocomotor, pilomotor and secretomotor neurons distinguished by size and neuropeptide content in superior cervical ganglia of mice,” J. Auton. Nerve Syst., 34, 171–183 (1991).

    Article  CAS  Google Scholar 

  13. L. Klimaschewski, W. Kummer, and C. Heym, “Localization, regulation and function of neurotransmitters and neuromodulators in cervical sympathetic ganglia,” Microsc. Res. Tech., 35, 44–68 (1996).

    Article  PubMed  CAS  Google Scholar 

  14. P. M. Masliukov, V. A. Pankov, A. A. Strelkov, E. A. Masliukova, V. V. Shilkin, and A. D. Nozdrachev, “Morphological features of neurons innervating different viscera in the cat stellate ganglion in postnatal ontogenesis,” Aut. Neurosci. Basic Clin., 84, 169–175 (2000).

    Article  CAS  Google Scholar 

  15. P. M. Masliukov, V. V. Shilkin, A. D. Nozdrachev, and J.-P. Timmermans, “Histochemical features of neurons in the cat stellate ganglion during postnatal ontogenesis,” Aut. Neurosci. Basic Clin., 106, 84–90 (2003).

    Article  CAS  Google Scholar 

  16. M. A. Morales, K. Holmberg, Z. Q. Xu, C. Cozzari, B. K. Hartman, P. Emson, M. Goldstein, L. G. Elfvin, and T. Hokfelt, “Localization of choline acetyltransferase in rat peripheral sympathetic neurons and its coexistence with nitric oxide synthase and neuropeptides,” Proc. Natl. Acad. Sci. USA, 92, 11819–11823 (1995).

    Google Scholar 

  17. D. W. Pincus, E. M. DiCicco-Bloom, and I. B. Black, “Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts,” Nature, 343, 564–567 (1990).

    Article  PubMed  CAS  Google Scholar 

  18. V. Roudenok, “Changes in the expression of neuropeptide Y (NPY) during maturation of human sympathetic ganglionic neurons: correlations with tyrosine hydroxylase immunoreactivity,” Ann. Anat., 182, 515–519 (2000).

    Article  PubMed  CAS  Google Scholar 

  19. H. M. Young, R. B. Anderson, and C. R. Anderson, “Guidance cues involved in the development of the peripheral autonomic nervous system,” Aut. Neurosci. Basic Clin., 112, 1–14 (2004).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Normal Physiology, Yaroslavl State Medical Academy, 5 Revolyutsionnaya Street, 150000, Yaroslavl, Russia

    P. M. Maslyukov

  2. Department of General Physiology, St. Petersburg State University, 7/9 Universitetskaya Bank, 199034, St. Petersburg, Russia

    A. D. Nozdrachev

  3. Laboratory of Cell Biology and Histology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

    J.-P. Timmermans

Authors
  1. P. M. Maslyukov
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  2. A. D. Nozdrachev
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  3. J.-P. Timmermans
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 92, No. 2, pp. 214–220, February, 2006.

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Maslyukov, P.M., Nozdrachev, A.D. & Timmermans, JP. Age-related characteristics of the neurotransmitter composition of neurons in the stellate ganglion. Neurosci Behav Physiol 37, 349–353 (2007). https://doi.org/10.1007/s11055-007-0020-9

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