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Oxidant stress in the pathogenesis of multiple sclerosis

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Abstract

We report here an analysis of measures of the intensification of lipid peroxidation and the state of the non-enzymatic and enzymatic components of the antioxidant defense system in different clinical forms and stages of multiple sclerosis. The data obtained support the role of oxidant stress in the development of the pathological process in multiple sclerosis.

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References

  1. S. Glants, Medical Biological Statistics [Russian translation from English], N. E. Buzinkashvili and D. V. Samoilov (eds.), Praktika, Moscow (1999).

    Google Scholar 

  2. I. A. Zavalishin and M. N. Zakharova, “Multiple sclerosis: current aspects of etiology and pathogenesis,” Zh. Nevrol. Psikhiat., 2, Special Issue, 10–17 (2003).

    Google Scholar 

  3. M. N. Zakharova, A. V. Peresedova, O. S. Brusova, et al., “Free-radical mechanisms in the pathogenesis of multiple sclerosis,” in: Proceedings of the Conference on Current Questions in Neurology, Neurosurgery, and Medical Genetics [in Russian], Ufa (1998), pp. 91–92.

  4. M. A. Lutskii, Systems Analysis and Multiphasic Modeling of the Components of Laboratory Status in Multiple Sclerosis [in Russian], Novyi Vzglyad, Voronezh (2002).

    Google Scholar 

  5. Multiple Sclerosis: Selected Questions in Theory and Practice [in Russian], I. A. Zavalishin and V. I. Golovkin (eds.), Moscow (2000).

  6. L. Diemel, “Macrophages in CNS remyelination: on friends or foe?” Neurochem. Res., 23, 341–347 (1998).

    Article  PubMed  CAS  Google Scholar 

  7. S. Li, “Novel injury mechanism in anoxia and trauma of spinal cord white matter: glutamate release via reverse Na+-dependent glutamate transport,” J. Neurosci., 19, 16 (1999).

    CAS  Google Scholar 

  8. J. Noseworthy, “Progress in determining the causes and treatment of multiple sclerosis,” Nature, 399, 40–48 (1999).

    Google Scholar 

  9. M. Renganathan, T. Cummins, W. Hormuzdiar, “Nitric oxide is an autocrine regulator of Na+ currents in axotomized C-type DRG neurons,” J. Neurophysiol., 83, 2431–2443 (2000).

    PubMed  CAS  Google Scholar 

  10. K. Smith, “Demyelination: the role of reactive oxygen and nitrogen species,” Brain Pathol., 9, 9–92 (1999).

    Google Scholar 

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Multiple Sclerosis, Supplement, No. 3, pp. 26–30, 2006.

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Lutskii, M.A., Esaulenko, I.É. Oxidant stress in the pathogenesis of multiple sclerosis. Neurosci Behav Physiol 37, 209–213 (2007). https://doi.org/10.1007/s11055-007-0003-x

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  • DOI: https://doi.org/10.1007/s11055-007-0003-x

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