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A possible mechanism for the effect of modifiable lateral inhibition in the striatum on the selection of conditioned reflex motor responses

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Abstract

A mechanism is proposed for the effects of striatal dopamine-modifiable lateral inhibition on the selection of conditioned reflex motor responses. According to this mechanism, activation of dopamine D1 (D2) receptors on strionigral (striopallidal) neurons facilitates long-term depression (potentiation) of the inhibitory inputs simultaneously with potentiation (depression) of the excitatory inputs, of sufficient strength to open NMDA channels. For “ weak” excitation, insufficient to open NMDA channels, the modification rules were of the opposite sign. Activation of presynaptic D2 (D1) receptors leads to decreases (increases) in GABA release from strionigral (striopallidal) axon terminals innervating strionigral (striopallidal) cells. As a result, dopamine-modifiable lateral inhibition simultaneously increases both the potentiation (depression) of the excitatory inputs to “strongly” activated strionigral (striopallidal) neurons, increasing (decreasing) their activity, and increases the depression (potentiation) of the excitatory inputs to the “weakly” activated strionigral (striopallidal) neurons, decreasing (increasing) their activity. Subsequent reorganization of neuron activity in the cortex-basal ganglia-thalamus-cortex circuit facilitates selection of conditioned reflex motor responses by further increasing (decreasing) the activity of those motor cortex neurons which were “strongly” (“weakly”) excited by the striatum in conditions of dopamine release in response to the conditioned stimulus.

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  1. Laboratory for the Neurophysiology of Learning, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 55, No. 4, pp. 444–458, July–August, 2005.

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Sil’kis, I.G. A possible mechanism for the effect of modifiable lateral inhibition in the striatum on the selection of conditioned reflex motor responses. Neurosci Behav Physiol 36, 631–643 (2006). https://doi.org/10.1007/s11055-006-0068-y

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