Abstract
The aim of the present work was to study qualitative and quantitative measures of histological changes in the nucleus ambiguus (NA) of the medulla oblongata and the cardiac autonomic ganglia (CAG) in growing animals in conditions of immobilization stress of different durations. Experiments were performed on 56 mongrel white rats aged 30 days. Immobilization stress was produced by placing rats in a special apparatus with a controllable internal volume for 3, 7, 15, and 30 days. The NA and CAG were studied on paraffin sections using neurohistological methods and quantitative analysis. Morphological and morphometric changes, consisting of a delay in the growth of neurocyte cell and nucleus volumes, as compared with controls, were seen both in the NA of the medulla oblongata and the CAG and were evaluated as impairments in the histogenesis of nerve tissue during postnatal ontogenesis. The extent of structural changes in these components of the autonomous nervous system was directly dependent on the duration of the experimental treatment.
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REFERENCES
G. G. Avtandilov, Medical Morphometry [in Russian], Meditsina, Moscow (1990).
V. P. Bisyarina, V. M. Yakovlev, and P. Ya. Kuksa, Arterial Vessels and Age [in Russian], Meditsina, Moscow (1986).
A. V. Grigor'eva, Quantitative Studies of Nuclear DNA in Rat Intracardiac Neurocytes in Normal Conditions and after Various Experimental Procedures [in Russian], Author's abstract of thesis for doctorate in medical sciences, Moscow (1976).
G. N. Kryzhanovskii, “General pathology of the nervous system,” Pat. Fiziol., No. 5, 75–84 (1989).
E. V. Malysheva, A. V. Zamotrinskii, and I. Yu. Malyshev, “Development of the phenomenon of adaptive stabilization of structures and adaptive defense of the heart in rats of different genetic lines: the role of heat shock protein hsp70,” Byull. Eksperim. Biol., 118, No. 8, 126–129 (1994).
R. P. Samusev, A. V. Smirnov, V. A. Areeva, et al., “Morphological changes in various organs in growing rats in conditions of limited movement activity,” Morfologiya, 121, No. 2–3, 140 (2002).
A. V. Smirnov and V. B. Pisarev, “Structural changes in intracardiac ganglia in immature rats in immobilization stress,” Vestn. Volgograd. Med. Akad., 52, No. 3, 27–29 (1997).
K. V. Sudakov, “New aspects of the classical concept of stress,” Byull. Eksperim. Biol., 123, No. 2, 124–130 (1997).
L. S. Ul'yanskii, “Vegetative regulation of cardiac activity in emotional stress,” in: Emotional Stress: Theoretical and Clinical Aspects [in Russian], Press and Information Committee, Volgograd (1997), pp. 89–93.
V. N. Shvalev, A. A. Sosunov, and G. Guski, Morphological Bases of Cardiac Innervation [in Russian], Nauka, Moscow (1992).
D. Garcia-Ovejero, J. L. Trejo, I. Ciriza, et al., “Space flight affects magnocellular supraoptic neurons of young prepubertal rats: transient and permanent effects,” Brain Res. Dev. Brain Res., 130, No. 2, 191–205 (2001).
S. W. Porges, “The polyvagal theory: phylogenetic contributions to social behavior,” Physiol. Behav., 79, No. 3, 503–513 (2003).
S. F. Reed, G. Ohel, R. David, and S. W. Porges, “A neural explanation of fetal heart rate patterns: a test of the polyvagal theory,” Dev. Psychobiol., No. 35, 108–118 (1999).
J. M. Reul, A. Bilang-Bleuel, S. Droste, et al., “New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders,” Z. Rheumatol., 59,Suppl. 2, 22–25 (2000).
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Translated from Morfologiya, Vol. 127, No. 1, pp. 21–24, January–February, 2005.
Director Professor M. Yu. Kapitonova
Director Professor V. B. Pisarev
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Smirnov, A.V., Pisarev, V.B. & Samusev, R.P. Structural Changes in the Nucleus Ambiguus of the Medulla Oblongata and Intracardiac Ganglia in Growing Rats in Immobilization Stress. Neurosci Behav Physiol 36, 279–282 (2006). https://doi.org/10.1007/s11055-006-0012-1
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DOI: https://doi.org/10.1007/s11055-006-0012-1