Abstract
Cross-correlation histograms were plotted to study the linkage of spike activity in simultaneously recorded neurons in the central nucleus of the right and left amygdala in rabbits in calm waking, after 24 hours of food deprivation, in satiation, and in emotional tension (on presentation of dogs). Histograms showed peaks displaced from zero in 50–67% of cases. In hunger, many cases (52%) showed pairs in which the first neuron to discharge was in the left amygdala, this being followed by a neuron in the right amygdala (peaks from 10–50 and 130–150 msec). Firing in the opposite order was seen more rarely (36%). On presentation of dogs, there was an increase in the number of cases showing a common input to neurons, along with an increase in the leading role of neurons in the right amygdala (57%), due to increases in inhibitory influences from this area on cells in the left amygdala. The interaction of amygdalar neurons in these states was in most cases at frequencies in the delta range (74%), mainly at 2–4 Hz.
Similar content being viewed by others
REFERENCES
Ya. Buresh, M. Petran', and I. Zakhar, Electrophysiological Study Methods [Russian translation], Foreign Literature Press, Moscow (1962).
G. L. Vanetsian, “Functional asymmetry of the cat amygdala in conditioned reflex activity,” in: The Brain and Behavior [in Russian], Nauka, Moscow (1990), pp. 69–81.
V. A. Zosimovskii, “The shapes of auto-and cross-correlation histograms of spike flows in monosynaptically interacting neurons,” Zh. Vyssh. Nerv. Deyat., 36, No. 4, 760–766 (1986).
R. Yu. Il'yuchenok, M. A. Gilinskii, L. V. Loskutova, N. I. Dubrovina, and N. V. Vol'f, The Amygdaloid Complex (Connections, Behavior, Memory [in Russian], Nauka, Novosibirsk (1981).
A. K. Malikova and E. V. Petrova, “Thermal activity in the rabbit brain in the motivational states of hunger and thirst,” Zh. Vyssh. Nerv. Deyat., 48, No. 4, 623–629 (1998).
A. D. Nozdracheva and M. P. Chernysheva, Visceral Reflexes [in Russian], Leningrad State University Press, Leningrad (1989).
I. V. Pavlova, “Linkage of the spike activity of neurons in the right and left lateral hypothalamus in food motivation,” Zh. Vyssh. Nerv. Deyat., 51, No. 4, 461–466 (2001).
I. V. Pavlova, “The spike activity of individual neurons in the amygdala and hypothalamus in bilateral recordings in food motivation,” Zh. Vyssh. Nerv. Deyat., 54, No. 6, 776–784 (2004).
I. V. Pavlova, I. V. Volkov, and V. N. Mats, “The effects of stimulation of the lateral hypothalamus on the linkage of spike activity in neocortical neurons in the rabbit,” Zh. Vyssh. Nerv. Deyat., 46, No. 6, 1068–1074 (1996).
I. V. Pavlova and V. N. Mats, “Functional asymmetry of the rabbit lateral hypothalamus in food motivation,” Zh. Vyssh. Nerv. Deyat., 46, No. 4, 740–744 (1996).
R. A. Pavlygina and Yu. V. Lyubimov, “Spectral characteristics of the electrical activity of the rabbit brain in hunger,” Zh. Vyssh. Nerv. Deyat., 44, No. 1, 57–64 (1994).
L. A. Preobrazhenskaya, “Asymmetry in the activity of the cerebral hemispheres in dogs in the state of calm waking during exposure to sensory stimuli and food deprivation,” Zh. Vyssh. Nerv. Deyat., 49, No. 2, 287–300 (1999).
P. V. Simonov, The Motivated Brain [in Russian], Nauka, Moscow (1987).
S. A. Chepurnov and N. E. Chepurnova, The Amygdaloid Complex of the Brain [in Russian], Moscow State University Press, Moscow (1981).
R. E. Adamec, “Evidence that limbic neural plasticity in the right hemisphere mediates partial kindling induced lasting increases in anxiety-like behavior: effects of low frequency stimulation (quenching?) on long term potentiation of amygdala efferents and behavior following kindling,” Brain Res., 839, No. 1, 133–152 (1999).
R. Adamec and B. Yong, “Neuroplasticity in specific limbic system circuits may mediate specific kindling induced changes in animal affect-implications for understanding anxiety associated with epilepsy,” Neurosci. Biobehav., 24, No. 7, 705–723 (2000).
R. Adolphs, D. Tranel, and H. Damasio, “Emotion recognition from faces and prosody following temporal lobectomy,” Neuropsychology, 15, No. 3, 396–404 (2001).
S. L. Andersen and M. N. Teicher, “Serotonine laterality in amygdala predicts performance in the elevated plus maze in rats,” Neuroreport, 10, No. 17, 3497–3500 (1999).
A. K. Anderson, D. D. Spencer, R. K. Fulbright, and E. A. Phelps, “Contribution of the anteromedial temporal lobes to the evaluation of facial emotion,” Neuropsychology, 14, No. 4, 526–536 (2000).
B. W. Colder, C. L. Wilson, R. C. Frysinger, L. C. Chao, R. M. Harper, and J. J. Engel, “Neuronal synchrony in relation to burst discharge in epileptic human temporal lobes,” J. Neurophysiol., 75, No. 6, 2496–2508 (1996).
K. Coleman-Mesches, J. A. Salinas, and J. L. McGaugh, “Unilateral amygdala inactivation after training attenuates memory for reduced reward,” Behav. Brain Res., 77, No. 1–2, 175–180 (1996).
R. J. Davidson, “Affective style, psychopathology, and resilience: brain mechanisms and plasticity,” Amer. Psychol., 55, No. 11, 1196–1214 (2000).
M. Davis, “The role of the amygdala in fear and anxiety,” Ann. Rev. Neurosci., 15, 353–375 (1992).
P. H. Desan, K. H. Lopez, H. B. Austin, and R. E. Jones, “Asymmetric metabolism of hypothalamic catecholamines alternates with side of ovulation in a lizard (Anolis carolinensis),” J. Exptl. Zool., 262, No. 1, 105–112 (1992).
T. Furmark, H. Fischer, G. Wik, M. Larsson, and M. Fredrikson, “The amygdala and individual differences in human fear conditioning,” Neuroreport, 8, No. 18, 3957–3960 (1997).
J. A. Harris, V. Guglielmotti, and M. Bentivoglio, “Diencephalic asymmetries,” Neurosci. Biobehav. Rev., 20, No. 4, 637–643 (1996).
N. H. Kalin, S. E. Shelton, R. J. Davidson, and A. E. Kelley, “The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament,” J. Neurosci., 21, No. 6, 2067–2074 (2001).
J. E. LeDoux, “Emotion circuits in the brain,” Ann. Rev. Neurosci., 23, 155–184 (2000).
G. P. Moore, J. P. Segundo, G. H. Perkel, and H. Levitan, “Statistical signs of synaptic interaction in neurons,” Biophys. J., 10, No. 9, 876–900 (1970).
J. S. Morris, A. Ohman, and R. J. Dolan, “Conscious and unconscious emotional learning in the human amygdala,” Nature, 393, No. 6684, 467–470 (1998).
T. Ono, R. Tamura, H. Nishijo, K. Nakamura, and E. Tabuchi, “Contribution of amygdalar and lateral hypothalamic neurons to visual information processing of food and nonfood in monkey,” Physiol. Behav., 45, No. 2, 411–421 (1989).
D. Pare and D. R. Collins, “Neuronal correlates of fear in the lateral amygdala: multiple extracellular recordings in conscious cats,” J. Neurosci., 20, No. 7, 2701–2710 (2000).
R. J. Perry, H. R. Rosen, J. H. Kramer, J. S. Beer, R. L. Levenson, and B. L. Miller, “Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementia,” Neurocase, 7, No. 2, 145–160 (2001).
M. T. Rogan and J. E. LeDoux, “LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit,” Neuron, 15, No. 1, 127–136 (1995).
M. H. Tabert, J. C. Borod, C. Y. Tang, G. Lange, T. C. Wei, R. Johnson, A. O. Nusbaum, and M. S. Buchsbaum, “Differential amygdala activation during emotional decision and recognition memory tasks using unpleasant words: an fMRI study,” Neuropsychologia, 39, No. 6, 556–573 (2001).
P. Vuilleumier, J. L. Armony, J. Dolan, and R. J. Dolan, “Effects of attention and emotion on face processing in the human brain: an event-related fMRI study,” Neuron, 30, No. 3, 829–841 (2001).
T. Zalla, E. Koechlin, P. Pietrini, G. Basso, P. Aquino, A. Sirigu, and J. Grafman, “Differential amygdala responses to winning and losing: a functional magnetic resonance imaging study in humans,” Eur. J. Neurosci., 12, No. 5, 1764–1770 (2000).
Author information
Authors and Affiliations
Additional information
__________
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 55, No. 1, pp. 43–51, January–February, 2005.
Rights and permissions
About this article
Cite this article
Pavlova, I.V. Linkage of Neuron Spike Activity in the Right and Left Amygdala in Food Motivation and Emotional Tension. Neurosci Behav Physiol 36, 217–225 (2006). https://doi.org/10.1007/s11055-006-0003-2
Issue Date:
DOI: https://doi.org/10.1007/s11055-006-0003-2