Abstract
Food-related operant conditioned reflexes to light were developed in four cats on the basis of the “ active choice” of reinforcement quality: short-latency pedal presses were reinforced with a mixture of meat and bread, while long-latency presses were reinforced with meat. Animals showed differences in their behavioral strategies: two preferred long-latency pedal presses (animals with “self-control”), while the other two preferred short-latency pedal presses (“impulsive” animals). At the second stage of the study, animals of both groups were retrained to a short-delay (1 sec) conditioned operant food-related reflex in response to light with meat reinforcement. Chronically implanted Nichrome semimicroelectrodes were used to record multicellular activity in the frontal cortex and hippocampus (field CA3). The interaction of neighboring neurons within the frontal cortex and hippocampus (local neural networks) and neurons of the frontal cortex and hippocampus (distributed frontohippocampal and hippocampofrontal neural networks) were assessed by statistical cross-correlation analysis of spike trains with an analysis epoch of 100 msec. The frontal and frontohippocampal neural networks had different modes of functional organization in the simplified task for the animals of the two groups. However, intergroup differences in local networks of the hippocampus persisted in conditions of the simplified task lacking the requirement for the animals to select the quality of the reinforcement, indicating the likely genetic determinacy of these networks.
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REFERENCES
P. V. Bukh-Viner, I. V. Volkov, and G. Kh. Merzhanova, “Spike collector,” Zh. Vyssh. Nerv. Deyat., 40, No.6, 1194–1199 (1990).
A. I. Venchikov and V. A. Venchikov, Basic Approaches to the Statistical Processing of Study Results in Physiology [in Russian], Meditsina, Moscow (1974).
G. Kh. Merzhanova, “Local and distributed neural networks and individuality,” Ros. Fiziol. Zh. im. I. M. Sechenova, 87, No.6, 873–884 (2001).
G. Kh. Merzhanova and A. I. Berg, “Selection of reinforcement quality depending on the duration of the delay in operant reactions in cats,” Zh. Vyssh. Nerv. Deyat., 41, No.5, 948–954 (1991).
G. Kh. Merzhanova and E. E. Dolbakyan, “Interneuronal frontoamygdalar interactions in cats trained to select reinforcement quality,” Zh. Vyssh. Nerv. Deyat., 48, No.3, 410–421 (1998).
G. Kh. Merzhanova, E. E. Dolbakyan, and A. Z. Partev, “Interneuronal relationships in the basolateral amygdala in cats trained to select the quality of food reinforcement,” Zh. Vyssh. Nerv. Deyat., 47, No.3, 500–506 (1997).
G. Kh. Merzhanova, E. E. Dolbakyan, and V. N. Khokhlova, “Interneuronal frontohippocampal interactions in cats trained to select the quality of reinforcement,” Zh. Vyssh. Nerv. Deyat., 52, No.3, 290–298 (2003).
M. Mishkin and T. Eppentseller, “The anatomy of memory”, V Mire Nauki (Russian translation of Scientific American), Mir, Moscow (1987), Vol. 8, No.1, pp. 30–40.
V. V. Nalimov, The Use of Mathematical Statistics in the Analysis of Substances [in Russian], State Physics-Mathematical Literature Press, Moscow (1960).
P. V. Simonov, The Emotional Brain [in Russian], Nauka, Moscow (1981).
P. V. Simonov, The Motivated Brain [in Russian], Nauka, Moscow (1987).
P. V. Simonov, Lectures on the Operation of the Brain [in Russian], Institute of Psychology, Russian Academy of Sciences, Moscow (1998).
M. G. Baxter, A. Parker, C. C. Lindner, A. D. Izquierdo, and E. A. Murray, “Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex,” J. Neurosci., 20, No.11, 4311–4319 (2000).
L. L. Baylis and G. Gaffan, “Amygdalectomy and ventromedial pre-frontal ablation produce similar deficits in food choice and in simple object discrimination learning for an unseen reward,” Exptl. Brain Res., 86, No.3, 617–622 (1991).
A. Bechara, H. Damasio, D. Tranel, and S. W. Anderson, “Dissociation of working memory from decision making within the human prefrontal cortex,” J. Neurosci., 18, No.1, 428–437 (1998).
R. Dias, T. W. Robbins, and A. C. Roberts, “Dissociation in pre-frontal cortex of affective and attentional shifts,” Nature, 380, No.6569, 69–72 (1996).
A. Escobar, “Nuevos conceptos sobre la significacion morfofunctional del sistema limbico,” Bol. Estud. Med. Biol., 34, No.1, 25–34 (1986).
J. E. Jarard, “On the role of the hippocampus in learning and memory in the rat,” Behav. Neural. Biol., 60, No.1, 9–26 (1993).
L. E. Jarrard, “What does the hippocampus really do?” Behav. Brain Res., 71, No.1, 1–10 (1995).
M. B. Moser and E. J. Moser, “Distributed encoding and retrieval of spatial memory in the hippocampus, ” J. Neurosci., 18, No.15, 7535–7542 (1998).
V. J. O’Boyle, E. A. Murray, and M. Mishkin, “Effects of excitotoxic amygdala-hippocampal lesions on visual recognition in Rhesus monkeys,” Soc. Neurosci. Abstr., 19, 438 (1993).
W. E. Pratt and S. J. Mitzumori, “Characteristics of basolateral amygdala neuronal firing on a spatial memory task involving differential reward,” Behav. Neurosci., 112, No.3, 554–570 (1998).
J. Rawing, “Associations across time: the hippocampus as a temporary memory store,” Behav. Brain Sci., 3, No.3, 479–496 (1985).
F. Reinoso-Suarez, Topographischer Hirnatlas der Katze (Fur Experimental-Physiologische Untersuchungen), Herausgegeben von E. Merck AG, Darmstadt, (1961).
R. D. Rogers, A. M. Owen, H. C. Middleton, E. J. Williams, J. D. Pickard, B. J. Sahakian, and T. W. Robbins, “Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex,” J. Neurosci., 20, No.19 9029–9038 (1999).
E. T. Rolls, “The orbito-frontal cortex,” Phil. Trans. Roy. Soc. Lond. B. Biol. Sci., 351, 1433–1444 (1996).
E. T. Rolls, H. D. Critchley, R. Mason, and E. A. Wilson, “Orbito-frontal cortex neurons: role in olfactory and visual association learning,” J. Neurophysiol., 75, 1970–1981 (1996).
E. T. Rolls, A. Treves, R. G. Robertson, P. Georges-Francois, and S. Panzeri, “Information about spatial view in an ensemble of primate hippocampal cells,” J. Neurophysiol., 79, No.4, 1797–1813 (1998).
Y. Sakurai, “Population coding by cell assemblies-what it really is in the brain,” Neurosci. Res., 26, No.1, 1–16 (1996).
G. Schoenbaum, A. A. Chiba, and M. Gallagher, “Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning,” Nat. Neurosci., 1, No.2, 155–159 (1998).
G. Schoenbaum, A. A. Chiba, and M. Gallagher, “Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning,” J. Neurosci., 19, No.5, 1876–1884 (1999).
N. Stolar, S. Sparenborg, E. Donchin, and M. Gabriel, “Conditional stimulus probability and activity of hippocampus, cingulate cortical and limbic thalamus neurons during avoidance conditioning in rabbits,” J. Behav. Neurosci., 103, No.5, 919–934 (1989).
R. Sutherland and R. McDonald, “Hippocampus, amygdala and memory deficits in rats,” Behav. Brain Res., 37, No.1, 57–79 (1990).
L. Tremblay and W. Schultz, “Relative rewards preference in primate orbitofrontal cortex,” Nature, 398, 704–708 (1999).
M. Watanabe, “Reward expectancy in primate prefrontal neurons,” Nature, 382, No.6592, 629–632 (1996).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti, Vol. 54, No. 4, pp. 508–518, July–August, 2004.
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Merzhanova, G.K., Dolbakyan, E.E. & Khokhlova, V.N. Organization of Frontohippocampal Neuronal Networks in Cats in Different Types of Directed Behavior. Neurosci Behav Physiol 35, 667–676 (2005). https://doi.org/10.1007/s11055-005-0109-y
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DOI: https://doi.org/10.1007/s11055-005-0109-y