Abstract
The first part of the present study used a model of Alzheimer’s disease in two groups of animals (three monkeys in each), given injections of neurotoxins (monkeys of group I) and physiological saline (monkeys of group II). Before injections, all monkeys were trained to discriminate stimuli containing different types of information (spatial frequency grids and geometrical figures of different colors and with different spatial relationships between objects) and to perform spatial selection. The dynamics of impairments in the characteristics of working memory were identified using delayed differentiation tasks in monkeys of both groups before injections and every two months after injections. Quantitative measures of impairments were made using the entropy of visual recognition, which characterizes uncertainty in decision-taking. The development of Alzheimer’s disease in rhesus macaques was characterized by a deficit of working memory, resulting from lesions to the two component processes of memory. Impairments of the first of these in monkeys of group I were manifest as a significant increase in entropy, which is associated with correct decision-taking. The magnitude of the increase depended on the type of visual information. Impairments of the second component were characterized by increases in entropy associated with refusals to take decisions and were independent of the delay duration and the type of visual information. Monkeys given injections of physiological saline showed no significant changes in these characteristics. The features of working memory were also studied in the second part of the investigation, using four groups of Rhesus macaques: intact, those with bilateral extirpation of the sulcus principalis or field 7 or both: degradation again identified two components. Entropy associated with this was increased significantly for most of the stimuli tested on monkeys of all extirpation groups as compared with intact animals. Significant differences were found in these characteristics for a number of stimuli, which depended on the location of the structures removed. The characteristics of impairments of the components of working memory resulting in the development of Alzheimer’s disease showed that the cholinergic mechanisms responsible for sensory processing differ from those involved in decision-taking. The structural-functional organization of the interaction of sensory and cognitive processes controlled by the motivation and attention systems is discussed, as is the role of the associative areas of the cortex.
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REFERENCES
M. M. Bongard, Visual Recognition [in Russian], Nauka, Moscow (1967).
V. D. Glezer and I. I. Tsukkerman, Information and Vision [in Russian], Nauka, Moscow, Leningrad (1961).
V. D. Glezer, K. N. Dudkin, A. M. Kuperman, L. I. Leushina, A. A. Nevskaya, N. F. Podvigin, and N. V. Prazdnikova, Mechanisms of Recognition of Visual Objects [in Russian], Nauka, Leningrad (1975).
V. D. Glezer, Vision and Thought [in Russian], Nauka, Leningrad (1985).
K. N. Dudkin, Visual Perception and Memory [in Russian], Nauka, Leningrad (1985).
K. N. Dudkin, V. K. Kruchinin, Yu. V. Skryminskii, and I. V. Chueva, Methods for Automated Studies of the Neuronal Mechanisms of Behavior [in Russian], Nauka, Leningrad (1989).
K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Processes of visual recognition in monkeys and their neuronal correlates in the visual cortex: effects of an m-cholinoreceptor blocker,” Ros. Fiziol. Zh. im. I. M. Sechenova, 78, No.10, 36–43 (1992).
K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Involvement of cholinergic structures of the prefrontal and lower temporal cortex in the processes of visual recognition in monkeys,” Ros. Fiziol. Zh. im. I. M. Sechenova, 79, No.2, 31–42 (1993).
K. N. Dudkin, V. K. Kruchinin, and I. V. Chueva, “Processes of synchronization in the mechanisms of short-term memory in monkeys: involvement of cholinergic and glutamatergic cortical structures,” Ros. Fiziol. Zh. im. I. M. Sechenova, 81, No.8, 128–134 (1995).
K. N. Dudkin and I. V. Chueva, “Relationship between learning characteristics in rhesus macaques and the properties of visual objects,” Ros. Fiziol. Zh. im. I. M. Sechenova, 81, No. 9, 25–34 (1995).
K. N. Dudkin and I. V. Chueva, “Specific features of the cholinergic mechanisms of short-term memory in monkeys for different types of visual information: characteristics of the effects of amizil,” Ros. Fiziol. Zh. im. I. M. Sechenova, 83, No.10, 16–23 (1997).
K. N. Dudkin, I. V. Chueva, and F. N. Makarov, “The role of the prefrontal and parietal areas of the cortex in learning and memory processes in monkeys,” Ros. Fiziol. Zh. im. I. M. Sechenova, 86, No.11, 1458–1470 (2000).
K. N. Dudkin, I. V. Chueva, F. N. Makarov, T. G. Bich, and A. E. Roér, “Impairments in working memory processes in monkeys in a model of Alzheimer’s disease,” Dokl. Ros. Akad. Nauk., 383, No.4, 562–564 (2002).
K. N. Dudkin, I. V. Chueva, F. N. Makarov, T. G. Bich, and A. E. Roér, “Characteristics of impairments of the sensory and cognitive components in the processes of working memory in monkeys in a model of Alzheimer’s disease,” Dokl. Ros. Akad. Nauk., 389, No.4, 1–3 (2003).
P. Bailey and C. von Bonin, The Neocortex of Macaca mulatta, Urbana (1947).
R. T. Bartus, “On neurodegenerative diseases, models, and treatment strategies. Lessons learned and lessons forgotten a generation following the cholinergic hypothesis,” Exptl. Neurol., 163, 495–529 (2000).
A. Collie and P. Maruff, “The neurophysiology of preclinical Alzheimer’s disease and mild cognitive impairment,” Neurosci. Biobehav. Rev., 24, 365–374 (2000).
A. Fine, C. Hoyle, C. J. Maclean, T. L. Levatte, H. F. Baker, and R. M. Riley, “Learning impairments following injection of a selective cholinergic immunotoxin, ME 20.4 IgG-saporin, into the basal nucleus of Meynert in monkeys,” Neurosci., 81, 331–343 (1997).
P. R. Hof, C. Bouras, J. Constantinidis, and J. H. Morrison, “Selective disconnection of specific visual association pathways in cases of Alzheimer’s disease presenting with Balint’s syndrome,” J. Neuropath. Exptl. Neurol., 49, No.2, 168–184 (1990).
J. McGaughy, B. J. Everitt, T. W. Robbins, and M. Sarter, “The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins,” Behav. Brain Res., 115, 251–263 (2000).
A. E. Roher, Y. M. Kuo, P. E. Potter, M. R. Emmerling, R. A. Durham, D. G. Walker, L. I. Sue, W. G. Honer, and T. G. Beach, “Cortical cholinergic denervation elicits vascular Aβ deposition,” Ann. N.Y. Acad. Sci., 829, 172–181 (2000).
D. H. Salat, J. A. Kaye, and J. A. Janowski, “Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer’s disease,” Arch. Neurol., 58, No.9, 1403–1408 (2001).
M. Sarter and J. P. Bruno, “Cognitive functions of cortical acetylcholine: toward a unifying hypothesis, ” Brain Res. Rev., 23, No.1–2, 28–46 (1997).
J. Schroder, M. S. Buchsbaum, L. Shihabuddin, et al., “Patterns of cortical activity and memory performance in Alzheimer’s disease,” Biol. Psychiatry, 49, No.5, 426–436 (2001).
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 89, No. 10, pp. 1226–1239, October, 2003.
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Dudkin, K.N., Chueva, I.V. & Makarov, F.N. Interaction of sensory and cognitive processes during visual recognition: The role of the associative areas of the cerebral cortex. Neurosci Behav Physiol 35, 407–416 (2005). https://doi.org/10.1007/s11055-005-0041-1
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DOI: https://doi.org/10.1007/s11055-005-0041-1