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Sol–gel synthesis and characterization of silica intertwined bismuth-based bioactive glass coalescence possibility towards biological applications

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Abstract

Bismuth being a versatile material with a wide range of therapeutic, regenerative, and antimicrobial properties lacks stability which is desired for materials to interact in a desired way with the physiological environment. Hence, synthesizing such materials requires a sensible approach because, they are sensitive to the composition of constituents, processing parameters, and the environment they are synthesized. In the current work, we introduced a novel approach to entrap bismuth in the mesoporous silica network such that the stability of the nanoparticles can be increased. The stability of the nanoparticles basically depends on the functionalization, morphology, and crystallographic arrangements of elements. This stability is expected to explore its opportunities for versatile biological applications such as bone tissue engineering and therapeutic and regenerative medicine where controlled drug release is the primary requirement. In the current work, we found the synthesized Nanoparticles were found to be stable, functional, and well-suited for possible to use in biological environments. Alongside the particle size ranging from 2 to 140 nm and exhibiting mesopore structures with uniform network connectivity is of critical interest towards biological applications. However, further biological studies are needed to confirm these findings, which will be our future work, but the current work suggests that these NPs have the potential to be a valuable new tool for bone tissue engineering that is in compliance with previous literature.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Mechanical Engineering, National Institute of Technology, Warangal, India

    Dheeraj Kumar Gara & Raghavendra Gujjala

  2. Department of Physics, National Institute of Technology, Warangal, India

    Syam Prasad P

  3. Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India

    Narayanan Madaboosi

Authors
  1. Dheeraj Kumar Gara
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  2. Raghavendra Gujjala
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  3. Syam Prasad P
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  4. Narayanan Madaboosi
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Contributions

• Conceptualization, formal analysis and investigation, and original draft preparation: Mr. Gara Dheeraj Kumar (principal author).

• Writing—review and editing, supervision: Dr. Gujjala Raghavendra

• Resources, supervision, editing and reviewing: Dr. P. Syam Prasad

• Writing—review and editing: Dr. M. S. Narayanan

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Correspondence to Raghavendra Gujjala.

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Gara, D.K., Gujjala, R., P, S.P. et al. Sol–gel synthesis and characterization of silica intertwined bismuth-based bioactive glass coalescence possibility towards biological applications. J Nanopart Res 26, 85 (2024). https://doi.org/10.1007/s11051-024-06001-7

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