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Titanate nanotubes modified with gallium and cerium and their cytotoxic activity

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Abstract

Sodium titanate nanotubes (NaTiNT) were synthesized using the hydrothermal method; subsequently, ion exchange reactions were carried out on the ions of Na+ present in the lamellar spaces of nanotubes by the intercalation of Ga3+ and/or Ce4+ and/or, revealing the presence of phases like: α-GaOOH and CeO2, probably decorating the surface of the nanotubes showing a complex heterostructure. As far as we know, these are the first titanate nanotubes intercalated with these two ions, gallium, and cerium, reported in the literature. Ion exchange processes preserved the original tubular structure of titanate nanotubes with relevant changes in their surface and interlamellar environment. It is known by the researchers that titanate nanotubes have low toxicity and acceptable biocompatibility. Here, we show that the insertion of Ce4+ and/or Ga3+ in titanate nanotubes increased its cytotoxic activity in melanoma cells, indicating that these hybrid nanomaterials are promising in future for health applications.

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Data Availability

The data that support the findings of this study are available on request from the corresponding author, BCV.

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Acknowledgements

We recognize the Geratec Laboratory of the State University of Piauí (UESPI), city of Teresina-PI and Francisco Henrique Lopes and Prof. Laecio Cavalcante for collaborating with the measurements of UV-Vis spectroscopy. Prof. F.C. Oliveira acknowledges the support of Estácio Teresina from the Productivity Research Program.

Funding

This work was supported by MCTI/CNPQ/Universal 28/2018 (grant #427084/2018–0). Prof. B.C. Viana acknowledges the support of CNPq-PQ-06/2019 (grant # 307901/2019–0), CNPq Nº 26/2021 (grant # 400998/2022–0), CNPq Nº 09/2022 (grant # 303315/2022–9), CNPq Nº 026/2021 (grant # 400998/2022–0), and Auxilio ao Pesquisador—PRPG/UFPI Nº 03/2022.

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Authors and Affiliations

  1. LIMAV-Interdisciplinary Laboratory for Advanced Materials, Materials Science and Engineering Graduate Program, UFPI - Federal University of Piaui, Teresina, PI, 64049-550, Brazil

    Keyla R. B. da Silva Costa, Marcel Leiner de Sá, Tainara G. de Oliveira & Bartolomeu C. Viana

  2. Centro Universitário UNINOVAFAPI, Teresina, PI, CEP 64073-505, Brazil

    Francilio de Carvalho Oliveira

  3. Laboratory of Cancerology, Pharmacology Graduate Program, Federal University of Piaui, Teresina, PI, 64049-550, Brazil

    Dalton Dittz & Bianca Sousa Leal

  4. Department of Biochemistry and Pharmacology, Federal University of Piaui, Teresina, PI, CEP 64049-550, Brazil

    Dalton Dittz & João Marcelo de Castro e Sousa

  5. Department of Physics, Federal University of Paraná, Curitiba, PR, CEP 81531-980, Brazil

    Guilherme J. P. Abreu

  6. Department of Physics - Materials Physics Lab (FisMat), Federal University of Piaui, Teresina, PI, CEP 64049-550, Brazil

    Suziete B. S. Gusmão, Yuset Guerra & Bartolomeu C. Viana

  7. Department of Chemical and Materials Engineering—DEQM, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, RJ, CEP 22541-041, Brazil

    Anupama Ghosh

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da Silva Costa, K.R.B., de Sá, M.L., de Carvalho Oliveira, F. et al. Titanate nanotubes modified with gallium and cerium and their cytotoxic activity. J Nanopart Res 25, 177 (2023). https://doi.org/10.1007/s11051-023-05824-0

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