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Controlled localization of magnetic nanoparticle mechanical activation in suspension exposed to alternating magnetic field using gradient magnetic field


In the past decade, nano-magnetomechanical actuation of biochemical systems for control of their properties on molecular level by means of magnetic nanoparticles in non-heating magnetic fields with frequency below 1 kHz has emerged as distinct branch in nanobiomedicine. From the fundamental point of view, nano-magnetomechanical actuation can provide molecular level locality and specificity; however, non-uniformity and instability of magnetic nanoparticle distribution within the living organism can become the source of unexpected side effects. The present work describes an advantageous physical method of nano-magnetomechanical actuation localization inside the macroscopic area with adjustable volume utilizing gradient magnetic field. Important spatial aspects of such method are considered.

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Magnetic nanoparticle


Magnetic field


Alternating magnetic field


Magnetic fluid hyperthermia




Nano-magnetomechanical actuation


Field free point


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The work was supported by the Russian Science Foundation grant 22–13-00261. Results were partially obtained using equipment of the Center for Collective Use of Scientific Equipment of G.R. Derzhavin Tambov State University supported by the Ministry of Science and Higher Education of the Russian Federation in the framework of agreement №. 075–15-2021–709 (unique project identifier RF––2296.61321X0037).

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All the authors contributed equally to writing the manuscript and discussing the results. All the authors have read and agreed to the published version of the manuscript.

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Correspondence to Alexander O. Zhigachev.

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The authors declare no competing interests.

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Golovin, Y.I., Zhigachev, A.O., Klyachko, N.L. et al. Controlled localization of magnetic nanoparticle mechanical activation in suspension exposed to alternating magnetic field using gradient magnetic field. J Nanopart Res 24, 167 (2022).

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  • Magnetic nanoparticles
  • Nano-magnetomechanical actuation
  • Biomedicine
  • Low-frequency non-heating magnetic field
  • Modeling and simulation