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Research progress of response strategies based on tumor microenvironment in drug delivery systems

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Abstract

In recent years, nanomedicines have shown tremendous progress in their targeted delivery systems and effective anticancer functions. The targeting, solubility, chemical stability, and degradability of nanocarriers make them widely used. The tumor microenvironment is different from that of normal cells. According to the response characteristics of pH, reducibility, hypoxia, reactive oxygen species, and enzymes, a series of tumor microenvironment stimulation–responsive nanocarrier delivery platforms were constructed.

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Funding

This study was funded by National Nature Science Foundation of China (81202480, 81302723).

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Correspondence to Xiumei Lu or Peng Zhang.

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The authors declare that they have no conflict of interest.

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Li, X., Yang, X., Wu, R. et al. Research progress of response strategies based on tumor microenvironment in drug delivery systems. J Nanopart Res 23, 64 (2021). https://doi.org/10.1007/s11051-020-05136-7

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  • DOI: https://doi.org/10.1007/s11051-020-05136-7

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