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RETRACTED ARTICLE: Stem cell membrane–camouflaged bioinspired nanoparticles for targeted photodynamic therapy of lung cancer

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This article was retracted on 08 October 2022

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Abstract

Photodynamic therapy (PDT) with photosensitizers has been considered an effective strategy for treating tumors by generating reactive oxygen species (ROS) to induce tumor cells apoptosis or necrosis. However, the poor water solubility, rapid blood clearance, and lack of effective targeting of the photosensitizer are still a serious challenge for its satisfactory anti-cancer efficacy. Herein, we fabricated a stem cell membrane–camouflaged gelatin nanogels (Ng), which integrating the drug loading capacity of Ng and targeting ability of stem cell membrane, endowed with many unique advantages for targeted drug delivery. This bioinspired drug delivery system composed of hydrophobic photosensitizer, chlorin e6 (Ce6)-loaded gelatin nanogels (Ng) (Ng/Ce6), as the inner cores and coated stem cell membrane vesicles (SCV) as the outer shells, noted as Ng/Ce6@SCV. The averaged hydrodynamic diameter of Ng/Ce6@SCV was 202.7 ± 11.7 nm (polydispersity index (PDI) = 0.113). Ng/Ce6@SCV could efficiently promote the cellular internalization of Ce6, and generate enough ROS in the tumor cells after near infrared (NIR) laser irradiation, which could efficiently suppress the growth of A549 tumor cells in vitro. After administration, Ng/Ce6@SCV exhibited targeting accumulation and long-term retention at tumor tissues, which was related to the immune escape and tumor targeting ability of the stem cell membrane. The in vivo anti-tumor activity results also demonstrated the enhanced anti-tumor effect of Ng/Ce6@SCV after NIR irradiation by significantly suppressed the primary tumor growth with minimal side effects. All the results indicated this polyphosphoester-based bioinspired nanodrug delivery system could be a suitable strategy for precise and effective PDT of cancers.

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Availability of data and materials

Data and material will be made available upon request.

Funding

This work was supported by the Scientific Development Program of Jilin Province (Nos. 201805240243LK.

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Authors and Affiliations

  1. Department of Operation Room of Anesthesiology, Hospital of Stomatology, Jilin University, Changchun, China

    Jinjie Feng, Shuyan Wang, Yumei Wang & Luping Wang

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  1. Jinjie Feng
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  2. Shuyan Wang
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  3. Yumei Wang
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  4. Luping Wang
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Contributions

Jinjie Feng carried out the in vitro and in vivo experiment and analyzed the data. Shuyan Wang organized the nanoparticle synthesis and drug loading. Yumei Wang revised the manuscript. Luping Wang conceived and supervised the study, and revised the manuscript. All authors read and approved the manuscript and agree to be accountable for all aspects of the research in ensuring that the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Luping Wang.

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The authors declare that they have no competing interest.

Ethics approval and consent to participate

Animal study was preapproved by Institutional Animal Care and Use Committee of Jilin University, and the studies were carried out in accordance with the approved protocol. The ethical approved protocol number is #2019-039.

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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s11051-022-05587-0

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Feng, J., Wang, S., Wang, Y. et al. RETRACTED ARTICLE: Stem cell membrane–camouflaged bioinspired nanoparticles for targeted photodynamic therapy of lung cancer. J Nanopart Res 22, 176 (2020). https://doi.org/10.1007/s11051-020-04915-6

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  • DOI: https://doi.org/10.1007/s11051-020-04915-6

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