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Effects of pore topology and iron oxide core on doxorubicin loading and release from mesoporous silica nanoparticles

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Abstract

Mesoporous silica nanoparticles (MSNs) have a network of pores that give rise to extremely high specific surface areas, making them attractive materials for applications such as adsorption and drug delivery. The pore topology can be readily tuned to achieve a variety of structures such as the hexagonally ordered Mobil Crystalline Material 41 (MCM-41) and the disordered “wormhole” (WO) mesoporous silica (MS) structure. In this work, the effects of pore topology and iron oxide core on doxorubicin loading and release were investigated using MSNs with pore diameters of approximately 3 nm and sub-100 nm particle diameters. The nanoparticles were loaded with doxorubicin, and the drug release into phosphate-buffered saline (PBS, 10 mM, pH 7.4) at 37 °C was monitored by fluorescence spectroscopy. The release profiles were fit using the Peppas model. The results indicated diffusion-controlled release for all samples. Statistically significant differences were observed in the kinetic host–guest parameters for each sample due to the different pore topologies and the inclusion of an iron oxide core. Applying a static magnetic field to the iron oxide core WO-MS shell materials did not have a significant impact on the doxorubicin release. This is the first time that the effects of pore topology and iron oxide core have been isolated from pore diameter and particle size for these materials.

Comparison of the release of doxorubicin from WO and iron oxide@WO particles into PBS

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Acknowledgements

Paul Mueller is acknowledged for assistance with the synthesis of materials. John Baer was supported through the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R25GM058939, the University of Iowa (UI) Office of the Vice President for Research and the UI Chief Diversity Office.

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  1. Department of Chemistry, University of Iowa, Iowa City, IA, 52242, USA

    Cicily J. Ronhovde, John Baer & Sarah C. Larsen

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  1. Cicily J. Ronhovde
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  2. John Baer
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Correspondence to Sarah C. Larsen.

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This work was partially supported by the National Science Foundation (NSF-CHE-1538847).

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Ronhovde, C.J., Baer, J. & Larsen, S.C. Effects of pore topology and iron oxide core on doxorubicin loading and release from mesoporous silica nanoparticles. J Nanopart Res 19, 215 (2017). https://doi.org/10.1007/s11051-017-3908-5

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