DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells

  • Elena-Laura Ursu
  • Florica Doroftei
  • Dragos Peptanariu
  • Mariana Pinteala
  • Alexandru Rotaru
Research Paper

DOI: 10.1007/s11051-017-3876-9

Cite this article as:
Ursu, EL., Doroftei, F., Peptanariu, D. et al. J Nanopart Res (2017) 19: 181. doi:10.1007/s11051-017-3876-9

Abstract

Single-walled carbon nanotubes (SWNTs) are 1D nanostructures with distinct physical and chemical properties that have shown great promise for applications in many fields, including biomedicine. Since for biomedical application the water solubility is crucial and SWNTs have low solubility, various methods (including polymer and biopolymer wrapping, chemical modifications) have been developed to solubilize and disperse them in water. Due to their unique optical properties such as photoluminescence in the NIR and strong resonant Raman signatures, they can be used as nanoprobes in biomedical imaging and phototherapies. Furthermore, decoration of SWNTs with noble metal nanoparticles will induce an excellent surface-enhanced Raman scattering (SERS) effect of the nanoparticles-SWNTs composites, with applications in cell imaging. Herein, we present a new and facile strategy for the DNA-assisted decoration of SWNTs with gold nanoparticles (AuNPs) and their application in SERS imaging. By ultrasonication at room temperature of SWNTs with AuNPs functionalized with synthetic DNA, SWNT-AuNPs nanocomposites with enhanced Raman signal were obtained. Among the important advantages of the proposed method are the presence of the free DNA overhangs around the SWNT-AuNPs suitable for post-synthetic modification of nanocomposite through hybridization of complementary DNA strands containing molecules of interest attached by well-developed bio-conjugation chemistry.

Graphical abstract

Keywords

Single-walled carbon nanotubes DNA Gold nanoparticles Surface-enhanced Raman scattering Cell imaging Biomedicine 

Supplementary material

11051_2017_3876_MOESM1_ESM.docx (10.5 mb)
ESM 1(DOCX 10725 kb)

Funding information

Funder NameGrant NumberFunding Note
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
  • PN-II-RU-TE-2014-4-1444

Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Elena-Laura Ursu
    • 1
  • Florica Doroftei
    • 1
  • Dragos Peptanariu
    • 1
  • Mariana Pinteala
    • 1
  • Alexandru Rotaru
    • 1
  1. 1.Romanian Academy, Centre of Advanced Research in Bionanoconjugates and Biopolymers“Petru Poni” Institute of Macromolecular ChemistryIașiRomania

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