Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
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The use of superparamagnetic iron oxide nanoparticles (SPIONs) and radiolabelled nanoparticles (NPs) has grown considerably over the recent years, and the SPIONs labelled with medicinal radionuclides offer new opportunities in multimodal diagnostics and in the drug-delivery systems for targeted alpha-particle therapy (TAT) driven by magnetic field gradient or by biologically active moieties bound on NPs shell. However, the mechanisms of NPs radiolabelling are not studied substantially and still remain unclear, even though the way of label attachment directly implies the stability of the label-nanoparticle construct. Since the 223Ra was the first clinically approved alpha-emitter, it is a promising nuclide for further development of its targeted carriers. We report here on the study of 223Ra uptake by the Fe3O4 SPIONs, together with an attempt to propose the 223Ra uptake mechanism by the Fe3O4 NPs in the presence of a phosphate buffer a typical formulation medium, under the pseudo-equilibrium conditions. Further, the in vitro stability tests of the prepared [223Ra]Fe3O4 NPs were performed to estimate the 223Ra label stability. The potential use of 223Ra-labelled SPIONs in theranostic applications is also discussed.
KeywordsMagnetic nanoparticles Radium Sorption Mechanism Fe3O4 Theranostics Biomedicine
Authors are grateful to prof. Jan John for helpful comments and kind support and to Dr. Valery Shkinev for the scientific concept inspiration. This work has been partially supported by: the Russian Foundation for Basic Research and Moscow city Government according to the research project No 15-33-70004 «mol_а_mos»; the Technology Agency of the Czech Republic, grant No.: TA03010027 and the Health Research Agency of the Czech Republic, grant No.: 16-30544A. The electron microscopy at the Institute of Macromolecular Chemistry was supported by the Technology Agency of the Czech Republic, project No.: TE01020118 and the Ministry of Education, Youth and Sports of the Czech Republic, project No.: POLYMAT LO1507, program NPU I.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
No animal studies were performed.
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