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Fe3O4/salicylic acid nanoparticles versatility in magnetic mediated vascular nanoblockage

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Abstract

An aqueous dispersion of Fe3O4/salicylic acid magnetic nanoparticles (SaMNPs) was synthesized by a modified Massart method, characterized by Inductively Coupled Plasma–Optic Emission Spectrometry (ICP-OES), High-Resolution Transmission Electron Microscopy (HRTEM) and Dynamic Light Scattering (DLS) methods, and tested on the chick chorioallantoic membrane (CAM) model to evaluate biocompatibility, biodistribution, intravascular time persistence, and ability to be magnetically target driven in order to block the blood supply into a tumor xenograft. ICP-OES, DLS, and HRTEM SaMNPs sample analyses showed a 0.356 mg/mL Fe concentration, a good stability in water (average Zeta potential of 39.3 mV), a hydrodynamic diameter around 52 nm and a core diameter in the 7–15 nm range for the Fe3O4 nanoparticles. In vivo CAM assay showed that SaMNPs were biocompatible with the chick embryo, were fixed almost completely by the liver, had no embolic potential, and a threshold-dose-dependent intravascular magnetic targeting time. Study on the CAM tumor model showed that SaMNPs could be used for long-term magnetically mediated nanoblocking of the capillary networks and 70-µm smaller arterioles.

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Acknowledgments

The participation of Buteică Sandra Alice was supported by the Project “Excellence program for multidisciplinary doctoral and postdoctoral research in chronic diseases,” Grant No. POSDRU/159/1.5/S/133377, partially supported by the Sectoral Operational Programme Human Resources Development 2007–2013, financed from the European Social Fund. The participation of Mihaiescu DE on this work was supported by the Sectoral Operational Programme Human Resources Development 2007-2013 of the Ministry of European Founds through the Financial Agreement POSDRU/159/1.5/S/132397.

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Authors and Affiliations

  1. Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares St 2, 200349, Craiova, Romania

    I. Mîndrilă & D. N. Mărgăritescu

  2. Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares St 2, 200349, Craiova, Romania

    S. A. Buteică

  3. Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Polizu St. 1-7, 011061, Bucharest, Romania

    D. E. Mihaiescu, G. Badea & A. Fudulu

Authors
  1. I. Mîndrilă
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  2. S. A. Buteică
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  3. D. E. Mihaiescu
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  4. G. Badea
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  5. A. Fudulu
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  6. D. N. Mărgăritescu
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Correspondence to I. Mîndrilă.

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Mîndrilă, I., Buteică, S.A., Mihaiescu, D.E. et al. Fe3O4/salicylic acid nanoparticles versatility in magnetic mediated vascular nanoblockage. J Nanopart Res 18, 10 (2016). https://doi.org/10.1007/s11051-015-3318-5

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  • DOI: https://doi.org/10.1007/s11051-015-3318-5

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