Abstract
In this study, composite nanoparticles comprising Au nanoparticle and quantum dots were built and used for contrast-enhanced computed tomography imaging (CT) and fluorescence dual-mode imaging in vivo. The nanoparticle exhibited good monodispersity and good biocompatibility, and had excellent CT contrast-enhancement effect and fluorescence imaging capability. They were appropriate for being used as dual-mode imaging probe in vivo.
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Acknowledgments
This work was supported by the National Natural Science Foundation of China (Grant No. 81271616, 81471697), the Natural Science Foundation of Hubei Province (2014CFB1010), the Key Technology R&D Program of Hubei Province (2014BBB003), Yellow Crane Talent (Science & Technology) Program of Wuhan City, and Applied Basic Research Program of Wuhan City. We also thank the Analytical and Testing Center (HUST) for their help in taking measurement.
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Ji-Tao Song and Xiao-Quan Yang equally contributed to this article.
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Song, JT., Yang, XQ., Zhang, XS. et al. Composite nanoparticle of Au and quantum dots for X-ray computed tomography and fluorescence dual-mode imaging in vivo. J Nanopart Res 17, 479 (2015). https://doi.org/10.1007/s11051-015-3296-7
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DOI: https://doi.org/10.1007/s11051-015-3296-7