Skip to main content
SpringerLink
Log in

Composite nanoparticle of Au and quantum dots for X-ray computed tomography and fluorescence dual-mode imaging in vivo

  • Research Paper
  • Published:
Journal of Nanoparticle Research Aims and scope Submit manuscript

Abstract

In this study, composite nanoparticles comprising Au nanoparticle and quantum dots were built and used for contrast-enhanced computed tomography imaging (CT) and fluorescence dual-mode imaging in vivo. The nanoparticle exhibited good monodispersity and good biocompatibility, and had excellent CT contrast-enhancement effect and fluorescence imaging capability. They were appropriate for being used as dual-mode imaging probe in vivo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  • Ai K, Liu Y, Liu J, Yuan Q, He Y, Lu L (2011) Large-scale synthesis of Bi2S3 nanodots as a contrast agent for in vivo X-ray computed tomography imaging. Adv Mater 23(42):4886–4891

    Article  Google Scholar 

  • Albanese A, Tang PS, Chan WCW (2012) The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng 14:1–16

    Article  Google Scholar 

  • Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC (2014) Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliver Rev 66:2–25

    Article  Google Scholar 

  • Chan Y, Zimmer JP, Troh MS, Steckel JS, Jain RK, Bawendi MG (2004) Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres. Adv Mater 16(23–24):2092–2097

    Article  Google Scholar 

  • Cho WS, Cho M, Jeong J, Choi M, Han BS, Shin HS, Hong J, Chung BH, Jeong J, Cho MH (2010) Size-dependent tissue kinetics of PEG-coated gold nanoparticles. Toxicol Appl Pharmacol 245(1):116–123

    Article  Google Scholar 

  • Cole LE, Ross RD, Tilley JMR, Tracy VG, Ryan KR (2015) Gold nanoparticles as contrast agents in x-ray imaging and computed tomography. Nanomedicine 10(2):321–341

    Article  Google Scholar 

  • Danhier F, Feron O, Préat V (2010) To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 148(2):135–146

    Article  Google Scholar 

  • Huang P, Bao L, Zhang C, Lin J, Luo T, Yang D, He M, Li Z, Gao G, Gao B, Fu S, Cui DX (2011) Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 32(36):9796–9809

    Article  Google Scholar 

  • Huang HH, Chen J, Meng YZ, Yang XQ, Zhang MZ, Yu Y, Ma ZY, Zhao YD (2013) Synthesis and characterization of Bi2S3 composite nanoparticles with high X-ray absorption. Mater Res Bull 48(10):3800–3804

    Article  Google Scholar 

  • Kim D, Jeong YY, Jon S (2010) A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 4(7):3689–3696

    Article  Google Scholar 

  • Kobayashi Y, Inose H, Nakagawa T, Gonda K, Takeda M, Ohuchi N, Kasuyac A (2011) Control of shell thickness in silica-coating of Au nanoparticles and their X-ray imaging properties. J Colloid Interface Sci 358(2):329–333

    Article  Google Scholar 

  • Kobayashi Y, Inose H, Nakagawa T, Gonda K (2013a) X-ray imaging technique using colloid solution of Au/silica core-shell nanoparticles. J Nanostruct Chem 3(1):1–6

    Google Scholar 

  • Kobayashi Y, Inose H, Nagasu R, Nakagawa T, Kubota Y, Gonda K, Ohuchi N (2013b) X-ray imaging technique using colloid solution of Au silica poly (ethylene glycol) nanoparticles. Mater Res Innovations 17(7):507–514

    Article  Google Scholar 

  • Li WP, Liao PY, Su CH, Yeh CS (2014) Formation of oligonucleotide-gated silica shell-coated Fe3O4-Au core-shell nanotrisoctahedra for magnetically targeted and near-infrared light-responsive theranostic platform. J Am Chem Soc 136(28):10062–10075

    Article  Google Scholar 

  • Mebius RE, Kraal G (2005) Structure and function of the spleen. Nat Rev Immunol 5(8):606–616

    Article  Google Scholar 

  • Moghimi SM (1995) Mechanisms of splenic clearance of blood cells and particles: towards development of new splenotropic agents. Adv Drug Delivery Rev 17(1):103–115

    Article  Google Scholar 

  • Oh MH, Lee N, Kim H, Park SP, Piao Y, Lee J, Jun SW, Moon WK, Choi SH, Hyeon T (2011) Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. J Am Chem Soc 133(14):5508–5515

    Article  Google Scholar 

  • Popovtzer R, Agrawal A, Kotov NA, Popovtzer A, Balter J, Carey TE, Kopelman R (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8(12):4593–4596

    Article  Google Scholar 

  • Qiu H, Cui B, Li G, Yang J, Peng H, Wang Y, Li N, Gao R, Chang Z, Wang Y (2014) Novel Fe3O4@ ZnO@ mSiO2 nanocarrier for targeted drug delivery and controllable release with microwave irradiation. J Phys Chem C 118(27):14929–14937

    Article  Google Scholar 

  • Selvan ST, Patra PK, Ang CY, Ying JY (2007) Synthesis of silica-coated semiconductor and magnetic quantum dots and their use in the imaging of live cells. Angew Chem 119(14):2500–2504

    Article  Google Scholar 

  • Shilo M, Reuveni T, Motiei M, Popovtzer R (2012) Nanoparticles as computed tomography contrast agents: current status and future perspectives. Nanomedicine 7(2):257–269

    Article  Google Scholar 

  • Song JT, Yang XQ, Zhang XS, Yan DM, Yao MH, Qin MY, Zhao YD (2015) Composite silica coated gold nanosphere and quantum dots nanoparticles for X-ray CT and fluorescence bimodal imaging. Dalton Trans 44:11314–11320

    Article  Google Scholar 

  • Sun Y, Feng W, Yang P, Huang C, Li F (2015) The biosafety of lanthanide upconversion nanomaterials. Chem Soc Rev 44(6):1509–1525

    Article  Google Scholar 

  • Xi D, Dong S, Meng X, Meng L, Ye J (2012) Gold nanoparticles as computerized tomography (CT) contrast agents. RSC Adv 2(33):12515–12524

    Article  Google Scholar 

  • Yang XQ, Meng YZ, Luo QM, Gong H (2010) High resolution in vivo micro-CT with flat panel detector based on amorphous silicon. J X-Ray Sci Technol 18(4):381

    Google Scholar 

  • Yang XQ, Gong H, Fu JW, Quan GT, Huang C, Luo QM (2012) Molecular imaging of small animals with fluorescent proteins: from projection to multimodality. Comput Med Imag Grap 36(4):259–263

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81271616, 81471697), the Natural Science Foundation of Hubei Province (2014CFB1010), the Key Technology R&D Program of Hubei Province (2014BBB003), Yellow Crane Talent (Science & Technology) Program of Wuhan City, and Applied Basic Research Program of Wuhan City. We also thank the Analytical and Testing Center (HUST) for their help in taking measurement.

Author information

Author notes

    Authors and Affiliations

    1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

      Ji-Tao Song, Xiao-Quan Yang, Xiao-Shuai Zhang, Dong-Mei Yan, Ming-Hao Yao, Meng-Yao Qin & Yuan-Di Zhao

    2. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

      Yuan-Di Zhao

    Authors
    1. Ji-Tao Song
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Xiao-Quan Yang
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Xiao-Shuai Zhang
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Dong-Mei Yan
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Ming-Hao Yao
      View author publications

      You can also search for this author in PubMed Google Scholar

    6. Meng-Yao Qin
      View author publications

      You can also search for this author in PubMed Google Scholar

    7. Yuan-Di Zhao
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Yuan-Di Zhao.

    Additional information

    Ji-Tao Song and Xiao-Quan Yang equally contributed to this article.

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Song, JT., Yang, XQ., Zhang, XS. et al. Composite nanoparticle of Au and quantum dots for X-ray computed tomography and fluorescence dual-mode imaging in vivo. J Nanopart Res 17, 479 (2015). https://doi.org/10.1007/s11051-015-3296-7

    Download citation

    • Received:

    • Accepted:

    • Published:

    • DOI: https://doi.org/10.1007/s11051-015-3296-7

    Keywords

    Search

    Navigation