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Charge effect of superparamagnetic iron oxide nanoparticles on their surface functionalization by photo-initiated chemical vapour deposition

An Erratum to this article was published on 07 November 2016


Diverse applications of superparamagnetic iron oxide nanoparticles (SPIONs) in the chemical and biomedical industry depend on their surface properties. In this paper, we investigate the effect of initial surface charge (bare, positively and negatively charged SPIONs) on the resulting physicochemical properties of the particles following treatment through photo-initiated chemical vapour deposition (PICVD). Transmission electron microscopy shows a nanometric polymer coating on the SPIONs and contact angle measurements with water demonstrate that their surface became non-polar following functionalization using PICVD. FTIR and XPS data confirm the change in the chemical composition of the treated SPIONs. Indeed, XPS data reveal an initial charge-dependent increase in the surface oxygen content in the case of treated SPIONs. The O/C percentage ratios of the bare SPIONs increase from 1.7 to 1.9 after PICVD treatment, and decrease from 1.7 to 0.7 in the case of negatively charged SPIONs. The ratio remains unchanged for positively charged SPIONs (1.7). This indicates that bare and negatively charged SPIONs showed opposite preference for the oxygen or carbon attachment to their surface during their surface treatment. These results reveal that both the surface charge and stereochemical effects have determinant roles in the polymeric coating of SPIONs with PICVD. Our findings suggest that this technique is appropriate for the treatment of nanoparticles.

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  • Bloemen M, Stappen TV, Willot P et al (2014) Heterobifunctional PEG ligands for bioconjugation reactions on iron oxide nanoparticles. PLoS One 9:e109475

    Article  Google Scholar 

  • Chang SY, Zheng N-Y, Chen C-S, Chen C-D, Chen Y-Y, Wang CRC (2007) Analysis of peptides and proteins affinity-bound to iron oxide nanoparticles by MALDI MS. J Am Soc Mass Spectr 18:910–918

    Article  Google Scholar 

  • Chen FF, Gerion D, Gray JW, Budinger TF (2009) Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics. US Patent WO2009045579 A2

  • Chen CL, Zhang H, Ye Q, Hsieh WY, Hitchens TK, Shen HH, Liu L, Wu YJ, Foley LM, Wang SJ, Ho C (2011) A new nano-sized iron oxide particle with high sensitivity for cellular magnetic resonance imaging. Mol Imaging Biol 13:825–839

    Article  Google Scholar 

  • Das M, Mishra D, Maiti TK, Basak A, Pramanik P (2008) Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting. Nanotechnology 19(41):415101

    Article  Google Scholar 

  • De Palma R, Peeters S, Van Bael MJ, Van den Rul H, Bonroy K, Laureyn W, Mullens J, Borghs G, Maes G (2007) Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible. Chem Mater 19:1821–1831

    Article  Google Scholar 

  • Dion CAD, Raphael W, Tong E, Tavares JR (2014) Photo-initiated chemical vapor deposition of thin films using syngas for the functionalization of surfaces at room temperature and near-atmospheric pressure. Surf Coat Technol 244:98–108

    Article  Google Scholar 

  • Eigler DM, Heinrich AJ, Loth S, Lutz CP (2014) Antiferromagnetic storage device. US Patent US8,724,376 B2

  • Fan C, Gao W, Chen Z, Fan H, Li M, Deng F, Chen Z (2011) Tumor selectivity of stealth multi-functionalized superparamagnetic iron oxide nanoparticles. Int J Pharm 404:180–190

    Article  Google Scholar 

  • Gawande MB, Branco PS, Varma RS (2013) Nano-magnetite (Fe3O4) as a support for recyclable catalysts in the development of sustainable methodologies. Chem Soc Rev 42:3371–3393

    Article  Google Scholar 

  • Georgelin T, Moreau B, Bar N, Villemin D, Cabuil V, Horner O (2008) Functionalization of Fe2O3 nanoparticles through the grafting of an organophosphorous ligand. Sens Actuator B 134:451–454

    Article  Google Scholar 

  • Hanini A, Schmitt A, Kacem K, Chau F, Ammar S, Gavard J (2011) Evaluation of iron oxide nanoparticle biocompatibility. Int J Nanomed 6:787–794

    Google Scholar 

  • Hu X, Yu JC, Gong J (2007) Fast production of self-assembled hierarchical α-Fe2O3 nanoarchitectures. J Phys Chem C 111:11180–11185

    Article  Google Scholar 

  • Jin H, Hong B, Kakar SS, Kang KA (2008) Tumor-specific nano-entities for optical detection and hyperthermic treatment of breast cancer. Adv Exp Med Biol 614:275–284

    Article  Google Scholar 

  • Johansson L-S, Campbell JM (2004) Reproducible XPS on biopolymers: cellulose studies. Surf Interface Anal 36:1018–1022

    Article  Google Scholar 

  • Kazemzadeh H, Ataei A, Rashchi F (2012) Synthesis of magnetite nanoparticles by reverse co-precipitation. Int J Mod Phys Conf Ser 5:160–167

    Article  Google Scholar 

  • Latham AH, Williams ME (2008) Controlling transport and chemical functionality of magnetic nanoparticles. Acc chem res 41(3):411–420

    Article  Google Scholar 

  • Matsuno R, Yamamoto K, Otsuka H, Takahara A (2004) Polystyrene-and poly (3-vinylpyridine)-grafted magnetite nanoparticles prepared through surface-initiated nitroxide-mediated radical polymerization. Macromolecules 37(6):2203–2209

    Article  Google Scholar 

  • Misra D, Wörhoff K, Mascher P (2003) Dielectrics in emerging technologies. In: Proceedings of the international symposium, Electrochem Society, Washington, DC

  • Namanga J, Foba J, Ndinteh DT, Yufanyi DM, Krause RWM (2013) Synthesis and magnetic properties of a superparamagnetic nanocomposite pectin-magnetite nanocomposite. J Nanomater 2013:87

    Article  Google Scholar 

  • Namvari M, Namazi H (2014) Clicking graphene oxide and Fe3O4 nanoparticles together: an efficient adsorbent to remove dyes from aqueous solutions. Int J Environ Sci Technol 11:1527–1536

    Article  Google Scholar 

  • Neouze MA, Schubert U (2008) Surface modification and functionalization of metal and metal oxide nanoparticles by organic ligands. Monatsh Chem 139:183–195

    Article  Google Scholar 

  • Nethaji S, Sivasamy A, Mandal AB (2013) Preparation and characterization of corn cob activated carbon coated with nano-sized magnetite particles for the removal of Cr(VI). Bioresour Technol 134:94–100

    Article  Google Scholar 

  • Obermayer D, Balu AM, Romero AA, Goessler W, Luque R, Kappe CO (2013) Nanocatalysis in continuous flow: supported iron oxide nanoparticles for the heterogeneous aerobic oxidation of benzyl alcohol. Green Chem 15:1530–1537

    Article  Google Scholar 

  • Robinson I, Tung LD, Maenosono S, Wälti C, Thanh NTK (2010) Synthesis of core-shell gold coated magnetic nanoparticles and their interaction with thiolated DNA. Nanoscale 2:2624–2630

    Article  Google Scholar 

  • Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ (2005) Nano-emulsions. Curr Opin Colloid Interface Sci 10:102–110

    Article  Google Scholar 

  • Stanicki D, Boutry S, Laurent S, Wacheul L, Nicolas E, Crombez D, Elst LV, Lafontaine DLJ, Muller RN (2014) Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging. J Mater Chem B 2(4):387–397

    Article  Google Scholar 

  • Stuart BH (2004) Infrared spectroscopy: fundamentals and applications. Wiley Press, New York

    Book  Google Scholar 

  • Sun S, Zeng H (2002) Size-controlled synthesis of magnetite nanoparticles. J Am Chem Soc 124:8204–8205

    Article  Google Scholar 

  • Uzun K, Çevik O, Şenel M, Sözeri H, Baykal A, Abasiyani MF, Toprak MS (2010) Covalent immobilization of invertase on PAMAM-dendrimer modified superparamagnetic iron oxide nanoparticles. J Nanopart Res 12:3057–3067

    Article  Google Scholar 

  • Veiseh O, Gunn J, Zhang M (2010) Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev 62(3):284–304

    Article  Google Scholar 

  • Vijayakumar R, Koltypin Y, Felner I, Gedanken A (2000) Sonochemical synthesis and characterization of pure nanometer-sized Fe3O4 particles. Mater Sci Eng A 286:101–105

    Article  Google Scholar 

  • Wang X, Liu L-H, Ramström O, Yan M (2009) Engineering nanomaterial surfaces for biomedical applications. Exp Biol Med 234:1128–1139

    Article  Google Scholar 

  • Wu W, He Q, Jiang C (2008) Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies. Nanoscale Res Lett 3:397–415

    Article  Google Scholar 

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We thank Professor Nick Virgilio from École Polytechnique de Montréal for access to the tensiometer. We also acknowledge the (CM)2 laboratory at École Polytechnique de Montréal for the TEM imaging of the samples. Finally, the authors would like to acknowledge the financial support of the National Science and Engineering Research Council of Canada (NSERC). The ARC (Research Contract AUWB-2010—10/15-UMONS-5), the FNRS, the Walloon Region, the COST TD1004 and TD1402, the UIAP VII program and the Center for Microscopy and Molecular Imaging (CMMI, supported by the European Regional Development Fund and the Walloon Region) are thanked for their support.

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Correspondence to Jason Robert Tavares.

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Javanbakht, T., Laurent, S., Stanicki, D. et al. Charge effect of superparamagnetic iron oxide nanoparticles on their surface functionalization by photo-initiated chemical vapour deposition. J Nanopart Res 17, 462 (2015).

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  • Superparamagnetic iron oxide nanoparticles
  • Contact angle
  • FTIR
  • TEM
  • XPS