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PEG-phospholipid-encapsulated bismuth sulfide and CdSe/ZnS quantum dot core–shell nanoparticle and its computed tomography/fluorescence performance

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Abstract

In this paper, polyethylene glycol-phospholipid structure is used to synthesize hybrid cluster of 40–50 nm diameter that contains hydrophobic bismuth sulfide nanoparticles and CdSe/ZnS quantum dots. The composite probe’s toxicity, CT imaging, and fluorescence imaging performance are also studied. Experimental results show that the nanocomposite hybrid cluster has obvious CT contrast enhancement and fluorescence imaging capability in vitro even after cellular uptake. It gives a CT number of 700 (Hounsfield units) at 15 mg/mL, higher than that of the current iobitridol CT contrast agent. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide experiment reveals that it has low cytotoxicity at concentration up to of 3.14 mg/mL of Bi, indicating the composite probe has potential ability for CT and fluorescence bimodal imaging.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81271616, 81471697), the Foundation for Innovative Research Groups of the NNSFC (Grant No. 61121004), the Natural Science Foundation of Hubei Province (2014CFB1010), the Key Technology R&D Program of Hubei Province (2014BBB003), and Yellow Crane Talent (Science & Technology) Program of Wuhan City. We also thank the Analytical and Testing Center (HUST) for their help in measurement procedures.

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    Authors and Affiliations

    1. Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

      Jun Chen, Xiao-Quan Yang, Meng-Yao Qin, Xiao-Shuai Zhang, Yang Xuan & Yuan-Di Zhao

    2. Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China

      Yuan-Di Zhao

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    1. Jun Chen
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    2. Xiao-Quan Yang
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    3. Meng-Yao Qin
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    4. Xiao-Shuai Zhang
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    5. Yang Xuan
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    Correspondence to Yuan-Di Zhao.

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    Jun Chen and Xiao-Quan Yang equally contributed to this article.

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    Chen, J., Yang, XQ., Qin, MY. et al. PEG-phospholipid-encapsulated bismuth sulfide and CdSe/ZnS quantum dot core–shell nanoparticle and its computed tomography/fluorescence performance. J Nanopart Res 17, 445 (2015). https://doi.org/10.1007/s11051-015-3253-5

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    • DOI: https://doi.org/10.1007/s11051-015-3253-5

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