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One-pot synthesis of FePt/CNTs nanocomposites for efficient cellular imaging and cancer therapy

Journal of Nanoparticle Research volume 17, Article number: 444 (2015) Cite this article

Abstract

Here, we developed a facile route to synthesize carbon nanotube-based FePt nanocomposites (FePt/CNTs) as a potential theranostic platform in the cancer treatment. FePt/CNTs were firstly synthesized via one-pot polyol route, and then functionalized with 6-arm-polyethylene glycol-amine polymer. The average size of FePt nanoparticles (NPs) is 3–4 nm, which is dispersed on the CNT surface (ca.50–150 nm). The as-prepared FePt NPs display high cytotoxicity by highly reactive oxygen species in cancer cells. Folic acid and fluorescein isothiocyanate are assembled onto the surface of FePt/CNTs for effective targeting of folate receptor-positive cancer cells and simultaneously for the visualization of cellular uptake. Therefore, the FePt/CNTs NPs capability of simultaneously performing diagnosis, therapy, and targeting is, therefore, promising for future potential widespread application in biomedicine.

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Acknowledgments

Financial support of this work by the Natural Science Foundation of China (Nos. 21375057 and 201405074), Shandong Province Natural Science Foundation (No. ZR2013BL007), and the National undergraduate training programs for innovation and entrepreneurship (No. 201410452006) is gratefully acknowledged.

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Authors and Affiliations

  1. School of Chemistry & Chemical Engineering, Shandong Provincial Key Laboratory of Detection Technology for Tumor Makers, Linyi University, Linyi, 276000, Shandong, People’s Republic of China

    Weihong Chen, Xiuwen Zheng, Wei Zhang & Xin Wen

  2. Linyi Tumor Hospital, Linyi, 276000, Shandong, People’s Republic of China

    Shulian Li

  3. Shandong Normal University, Jinan, 250000, Shandong, People’s Republic of China

    Ludan Yue

  4. Shandong University of Technology, Zibo, 255000, Shandong, People’s Republic of China

    Jinlong Wang

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  1. Weihong Chen
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  2. Xiuwen Zheng
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  3. Shulian Li
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  4. Wei Zhang
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  5. Xin Wen
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  6. Ludan Yue
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  7. Jinlong Wang
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Correspondence to Xiuwen Zheng.

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Chen, W., Zheng, X., Li, S. et al. One-pot synthesis of FePt/CNTs nanocomposites for efficient cellular imaging and cancer therapy. J Nanopart Res 17, 444 (2015). https://doi.org/10.1007/s11051-015-3247-3

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  • DOI: https://doi.org/10.1007/s11051-015-3247-3

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