Here, we developed a facile route to synthesize carbon nanotube-based FePt nanocomposites (FePt/CNTs) as a potential theranostic platform in the cancer treatment. FePt/CNTs were firstly synthesized via one-pot polyol route, and then functionalized with 6-arm-polyethylene glycol-amine polymer. The average size of FePt nanoparticles (NPs) is 3–4 nm, which is dispersed on the CNT surface (ca.50–150 nm). The as-prepared FePt NPs display high cytotoxicity by highly reactive oxygen species in cancer cells. Folic acid and fluorescein isothiocyanate are assembled onto the surface of FePt/CNTs for effective targeting of folate receptor-positive cancer cells and simultaneously for the visualization of cellular uptake. Therefore, the FePt/CNTs NPs capability of simultaneously performing diagnosis, therapy, and targeting is, therefore, promising for future potential widespread application in biomedicine.
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Financial support of this work by the Natural Science Foundation of China (Nos. 21375057 and 201405074), Shandong Province Natural Science Foundation (No. ZR2013BL007), and the National undergraduate training programs for innovation and entrepreneurship (No. 201410452006) is gratefully acknowledged.
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Chen, W., Zheng, X., Li, S. et al. One-pot synthesis of FePt/CNTs nanocomposites for efficient cellular imaging and cancer therapy. J Nanopart Res 17, 444 (2015). https://doi.org/10.1007/s11051-015-3247-3