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Facile fabrication of CdSe/CdS quantum dots and their application on the screening of colorectal cancer

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Abstract

In this paper, a facile aqueous route to water-soluble CdSe/CdS quantum dots (QDs) under mild conditions has been developed. The samples were characterized by means of transmission electron microscopy, energy-dispersive X-ray spectroscopy, and photoluminescence (PL) spectroscopy. The PL property of the QDs can be controlled by adjusting the reaction time. The CdSe/CdS QDs after 48-h reaction with size of 5 nm have the strongest PL intensity located at 553 nm, and the highest quantum yield of 19.9 %. The obtained QDs were applied for the colorectal cancer screening. The QDs could be conjugated with antibody of aldo-keto reductase family 1, member B10 (AKR1B10) for the detection of AKR1B10. The AKR1B10 in PBS/5 % serum solution with concentration of 1 ng/mL could be well calibrated, and the limit of detection could be lower than 0.05 ng/mL.

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Acknowledgments

This study was supported by Zhejiang science and technology project for medical and health (2015KYA015).

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Authors and Affiliations

  1. Department of Colorectal Surgery, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, Zhejiang, China

    Hongfeng Cao, Quanjin Dong, Shiliang Tu, Rui Chai & Qiaoqiong Dai

  2. School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China

    Li Hu

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  1. Hongfeng Cao
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  2. Quanjin Dong
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  3. Li Hu
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  4. Shiliang Tu
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  5. Rui Chai
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  6. Qiaoqiong Dai
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Correspondence to Quanjin Dong.

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Cao, H., Dong, Q., Hu, L. et al. Facile fabrication of CdSe/CdS quantum dots and their application on the screening of colorectal cancer. J Nanopart Res 17, 430 (2015). https://doi.org/10.1007/s11051-015-3224-x

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  • DOI: https://doi.org/10.1007/s11051-015-3224-x

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