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Optimal structure of particles-based superparamagnetic microrobots: application to MRI guided targeted drug therapy

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Abstract

This paper presents an optimal design strategy for therapeutic magnetic micro carriers (TMMC) guided in real time by a magnetic resonance imaging (MRI) system. As aggregates of TMMCs must be formed to carry the most amount of drug and magnetic actuation capability, different clustering agglomerations could be arranged. Nevertheless, its difficult to predict the hydrodynamic behavior of any arbitrary-shaped object due to the nonlinear hydrodynamic effects. Indeed, the drag effect is related not only to the properties of the bolus but also to its interaction with the fluid viscosity, the free-stream velocity and the container geometry. In this work, we propose a mathematical framework to optimize the TMMC aggregates to improve the steering efficiency in experimental endovascular conditions. The proposed analysis is carried out on various sizes and geometries of microcarrier: spherical, ellipsoid-like, and chain-like of microsphere structures. We analyze the magnetophoretic behavior of such designs to exhibit the optimal configuration. Based on the optimal design of the boluses, experimental investigations were carried out in mm-sized fluidic artery phantoms to demonstrate the steerability of the magnetic bolus using a proof-of-concept setup. The experiments demonstrate the steerability of the magnetic bolus under different velocity, shear-stress, and trajectory constraints with a laminar viscous fluidic environment. Preliminary experiments with a MRI system confirm the feasibility of the steering of these TMMCs in hepatic artery microchannel phantom.

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References

  • Alexiou C, Tietze R, Schreiber E, Jurgons R, Richter H, Trahms L, Rahn H, Odenbach S, Lyer S (2011) Cancer therapy with drug loaded magnetic nanoparticles-magnetic drug targeting. J Magn Magn Mater 323(10):1404–1407

    Article  Google Scholar 

  • Arcese L, Fruchard M, Ferreira A (2012) Endovascular magnetically guided robots: navigation modeling and optimization. IEEE Trans Biomed Eng 59(4):977–987

    Article  Google Scholar 

  • Belharet K, Folio D, Ferreira A (2013) Simulation and planning of a magnetically actuated microrobot navigating in the arteries. IEEE Trans Biomed Eng 60(4):994–1001

    Article  Google Scholar 

  • Chhabra R, Agarwal S, Chaudhary K (2003) A note on wall effect on the terminal falling velocity of a sphere in quiescent newtonian media in cylindrical tubes. Powder Technol 129(1):53–58

    Article  Google Scholar 

  • Davies JM (1949) The aerodynamics of golf balls. J Appl Phys 20(9):821–828

    Article  Google Scholar 

  • Dreyfus R, Baudry J, Roper ML, Fermigier M, Stone HA, Bibette J (2005) Microscopic artificial swimmers. Nature 437(7060):862–865

    Article  Google Scholar 

  • Evans AA, Lauga E (2010) Propulsion by passive filaments and active flagella near boundaries. Phys Rev E 82(4):041915

    Article  Google Scholar 

  • Filippov A (2000) Drag and torque on clusters of n arbitrary spheres at low reynolds number. J Colloid Interface Sci 229(1):184–195

    Article  Google Scholar 

  • Floyd S, Pawashe C, Sitti M (2009) Two-dimensional contact and noncontact micromanipulation in liquid using an untethered mobile magnetic microrobot. IEEE Trans Robot 25(6):1332–1342

    Article  Google Scholar 

  • Folio D, Dahmen C, Wortmann T, Zeeshan MA, Shou K, Pané S, Nelson BJ, Ferreira A, Fatikow S (2011) Mri magnetic signature imaging, tracking and navigation for targeted micro/nano-capsule therapeutics. In: IEEE/RSJ international conference on intelligent robots and systems (IROS’11), IEEE, pp 1297–1303

  • Fusco S, Sakar MS, Kennedy S, Peters C, Bottani R, Starsich F, Mao A, Sotiriou GA, Pané S, Pratsinis SE et al (2014) An integrated microrobotic platform for on-demand, targeted therapeutic interventions. Adv Mater 26(6):952–957

    Article  Google Scholar 

  • Geller A, Mondy L, Rader D, Ingber M (1993) Boundary element method calculations of the mobility of nonspherical particles—1. linear chains. J Aerosol Sci 24(5):597–609

    Article  Google Scholar 

  • Haberman WL, Sayre RM (1958) Motion of rigid and fluid spheres in stationary and moving liquids inside cylindrical tubes. David Taylor Model Basin Reports 1143, US Navy

  • Happel J, Brenner H (1983) Low reynolds number hydrodynamics: with special applications to particulate media, mechanics of fluids and transport processes, 3rd edn. Springer, Netherlands

    Google Scholar 

  • Kasper G, Niida T, Yang M (1985) Measurements of viscous drag on cylinders and chains of spheres with aspect ratios between 2 and 50. J Aerosol Sci 16(6):535–556

    Article  Google Scholar 

  • Kehlenbeck R, Felice RD (1999) Empirical relationships for the terminal settling velocity of spheres in cylindrical columns. Chem Eng Technol 22(4):303–308

    Article  Google Scholar 

  • Kishore N, Gu S (2010) Wall effects on flow and drag phenomena of spheroid particles at moderate reynolds numbers. Ind Eng Chem Res 49(19):9486–9495. doi:10.1021/ie1011189

    Article  Google Scholar 

  • Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D et al (2012) Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science 337(6095):738–742

    Article  Google Scholar 

  • Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108(6):2064–2110

    Article  Google Scholar 

  • Maccoll JW (1928) Aerodynamics of a spinning sphere. J R Aeronaut Soc 28:777–798

    Google Scholar 

  • Madhav GV, Chhabra R (1995) Drag on non-spherical particles in viscous fluids. Int J Miner Process 43(1):15–29

    Article  Google Scholar 

  • Martel S, Mathieu JB, Felfoul O, Chanu A, Aboussouan E, Tamaz S, Pouponneau P, Yahia L, Beaudoin G, Soulez G et al (2007) Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system. Appl Phys Lett 90(11):114105

    Article  Google Scholar 

  • Mathieu JB, Martel S (2009) Aggregation of magnetic microparticles in the context of targeted therapies actuated by a magnetic resonance imaging system. J Appl Phys 106(4):044904

    Article  Google Scholar 

  • Mathieu JB, Beaudoin G, Martel S (2006) Method of propulsion of a ferromagnetic core in the cardiovascular system through magnetic gradients generated by an mri system. IEEE Trans Biomed Eng 53(2):292–299

    Article  Google Scholar 

  • Morgan B, Kennedy AS, Lewington V, Jones B, Sharma RA (2011) Intra-arterial brachytherapy of hepatic malignancies: watch the flow. Nat Rev Clin Oncol 8(2):115–120

    Article  Google Scholar 

  • Nelson BJ, Kaliakatsos IK, Abbott JJ (2010) Microrobots for minimally invasive medicine. Annu Rev Biomed Eng 12:55–85

    Article  Google Scholar 

  • Pouponneau P, Leroux JC, Martel S (2009) Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization. Biomaterials 30(31):6327–6332

    Article  Google Scholar 

  • Pouponneau P, Leroux JC, Soulez G, Gaboury L, Martel S (2011) Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation. Biomaterials 32(13):3481–3486

    Article  Google Scholar 

  • Pouponneau P, Bringout G, Martel S (2014) Therapeutic magnetic microcarriers guided by magnetic resonance navigation for enhanced liver chemoembilization: a design review. Ann Biomed Eng 42(5):929–939

    Article  Google Scholar 

  • Unnikrishnan A, Chhabra R (1991) An experimental study of motion of cylinders in newtonian fluids: wall effects and drag coefficient. Can J Chem Eng 69(3):729–735. doi:10.1002/cjce.5450690315

    Article  Google Scholar 

  • Vartholomeos P, Mavroidis C (2012) In silico studies of magnetic microparticle aggregations in fluid environments for mri-guided drug delivery. IEEE Trans Biomed Eng 59(11):3028–3038

    Article  Google Scholar 

  • White FM, Corfield I (1991) Viscous fluid flow, vol 2. McGraw-Hill, New York

    Google Scholar 

  • Zhang L, Peyer KE, Nelson BJ (2010) Artificial bacterial flagella for micromanipulation. Lab Chip 10(17):2203–2215

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. INSA Centre Val de Loire, Université d’Orléans, PRISME EA 4229, Bourges, France

    Lyès Mellal, David Folio & Antoine Ferreira

  2. Hautes Études d’Ingénieur campus Centre, PRISME EA 4229, Châteauroux, France

    Karim Belharet

Authors
  1. Lyès Mellal
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  2. Karim Belharet
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  3. David Folio
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  4. Antoine Ferreira
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Correspondence to Antoine Ferreira.

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Guest Editors: Leonardo Ricotti, Arianna Menciassi

This article is part of the topical collection on Nanotechnology in Biorobotic Systems

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Mellal, L., Belharet, K., Folio, D. et al. Optimal structure of particles-based superparamagnetic microrobots: application to MRI guided targeted drug therapy. J Nanopart Res 17, 64 (2015). https://doi.org/10.1007/s11051-014-2733-3

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  • DOI: https://doi.org/10.1007/s11051-014-2733-3

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