A systematic study of antibacterial silver nanoparticles: efficiency, enhanced permeability, and cytotoxic effects
We report here a systematic study of the antibacterial behavior of silver nanoparticles coated with fatty acids (oleic: AgNP-O, linoleic: AgNP-L, and palmitic acids: AgNP-P) in water. We have found remarkable differences in their capability to penetrate bacteria cell over a broader range of particle size of ~4–96 nm compared to previously reported work, and a variable toxicity depending on the particles size. Our results indicate that silver nanoparticles stabilized with oleic acid showed clear advantages in antibacterial activity, penetration inside the bacteria cells, cytotoxicity, time effectiveness, efficiency, and stability against light.
KeywordsSilver Nanoparticles Antibacterial Cytotoxicity Permeability Environmental and health effects
- Cioffi N, Rai M (eds) (2012) Nano-antimicrobials, progress and prospects. Springer, HeidelbergGoogle Scholar
- Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO (2000) A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res 52(4):662–668. doi:10.1002/1097-4636(20001215)52:4<662:AID-JBM10>3.0.CO;2-31 CrossRefGoogle Scholar
- Taglietti A, Diaz-Fernandez YA, Amato E, Cucca L, Dacarro G, Grisoli P, Necchi V, Pallavicini P, Pasotti L, Patrini M (2012) Antibacterial activity of glutathione-coated silver nanoparticles against gram positive and gram negative bacteria. Langmuir 28(21):8140–8148. doi:10.1021/la3003838 CrossRefGoogle Scholar
- Tamayo LA, Zapata PA, Vejar ND, Azócar MI, Gulppi MA, Zhou X, Thompson GE, Rabagliati FM, Páez MA (2014) Release of silver and copper nanoparticles from polyethylene nanocomposites and their penetration into Listeria monocytogenes. Mat Sci Eng C 40:24–31. doi:10.1016/j.msec.2014.03.037 CrossRefGoogle Scholar
- Zapata PA, Tamayo L, Páez M, Cerda E, Azócar I, Rabagliati FM (2011) Nanocomposites based on polyethylene and nanosilver particles produced by metallocenic “in situ” polymerization: synthesis, characterization, and antimicrobial behavior. Eur Polym J 47(8):1541. doi:10.1016/j.eurpolymj.2011.05.008 CrossRefGoogle Scholar