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DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers

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Abstract

In this study, we report on the self assembly behavior and on stability studies of mixed (chimeric) nanosystems consisting of dipalmitoylphosphatidylcholine (DPPC) and poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) (MPOx) gradient copolymer in aqueous media and in fetal bovine serum (FBS). A gamut of light scattering techniques and fluorescence spectroscopy were used in order to extract information on the size and morphological characteristics of the nanoassemblies formed, as a function of gradient block copolymer content, as well as temperature. The hydrodynamic radii (R h) of nanoassemblies decreased in the process of heating up to 50 °C, while the fractal dimension (d f) values, also increased. Indomethacin was successfully incorporated into these chimeric nanocarriers. Drug release was depended on the components ratio. The present studies show that there are a number of parameters that can be used in order to alter the properties of chimeric nanosystems, and this is advantageous to the development of “smart” nanocarriers for drug delivery.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimioupolis, Zografou, 15771, Athens, Greece

    Natassa Pippa & Costas Demetzos

  2. Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635, Athens, Greece

    Natassa Pippa, Eleni Kaditi & Stergios Pispas

Authors
  1. Natassa Pippa
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  2. Eleni Kaditi
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  3. Stergios Pispas
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  4. Costas Demetzos
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Correspondence to Costas Demetzos.

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Stergios Pispas and Costas Demetzos contributed equally to this study.

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Pippa, N., Kaditi, E., Pispas, S. et al. DPPC/poly(2-methyl-2-oxazoline)-grad-poly(2-phenyl-2-oxazoline) chimeric nanostructures as potential drug nanocarriers. J Nanopart Res 15, 1685 (2013). https://doi.org/10.1007/s11051-013-1685-3

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