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Preparation of cytocompatible luminescent and magnetic nanohybrids based on ZnO, Zn0.95Ni0.05O and core@shell ZnO@Fe2O3 polymer grafted nanoparticles for biomedical imaging

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Abstract

ZnO, Zn0.95Ni0.05O and core@shell ZnO@γ-Fe2O3 nanoparticles (NPs) have been prepared by forced hydrolysis in polyol medium and then coated via the “grafting from” approach with poly(sodium-4-styrenesulfonate) and poly(sodium-4-styrenesulfonate–co–sodium methacrylate) in the case of ZnO. The surface-initiated atom transfer radical polymerization occurred from the surface-functionalized NPs with α-bromoisobutyric acid as initiator. The polymer chains were grown from the surface to yield hybrid NPs with a 1–3-nm thick organic shell. FT-IR, TGA and electron microscopy evidenced the presence of a polymer layer on the surface of NPs. Magnetic and optical properties of bare and coated NPs have been measured. Eventually, the weak cytotoxicity of coated NPs on human endothelial cell allows considering their potentialities as new tools for nanomedicine and biomedical imaging.

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Acknowledgments

Financial support for this study was provided by “Institut français de cooperation en Tunisie (IFC)”. The authors would like to thank Mr O. Brinza (Laboratoire de Sciences des Procédés et des Matériaux, CNRS UPR 3407, University Paris 13) for his help and expertise in TEM. We would like to express our thanks to the Cellular imaging platform of the IFR02 (Institut Claude Bernard/Xavier Bichat, Faculty of Medicine,University Paris Diderot) and P. Aschehoug (Laboratoire de Chimie Appliquée de l’Etat Solide, ENSCP, Paris) for the PL measurement. Authors thank Alain Derory, IPCMS UMR CNRS—University of Strasbourg, France, for technical assistance in magnetic measurements.

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Authors and Affiliations

  1. Département de Chimie, Unité de recherche UR11ES30, Faculté des sciences de Bizerte, Université de Carthage, 7021, Jarzouna, Tunisia

    I. Balti & L. S. Smiri

  2. Laboratoire de Sciences des Procédés et des Matériaux, LSPM, CNRS UPR 3407, Institut Galilée, Université Paris 13, 99 Avenue J.B. Clément, 93430, Villetaneuse, France

    I. Balti & N. Jouini

  3. Laboratoire de bio-ingénierie des polymères cardiovasculaires, Inserm U698, Institut Galilée, Université Paris 13, 99 Avenue J.B. Clément, 93430, Villetaneuse, France

    A. Barrère, V. Gueguen, L. Poussard, G. Pavon-Djavid, A. Meddahi-Pellé & F. Chaubet

  4. Département de Chimie des Matériaux Inorganiques, IPCMS UMR7504, CNRS-UDS, 23, rue du Loess BP43, Strasbourg cedex 2, France

    P. Rabu

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  1. I. Balti
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Correspondence to F. Chaubet.

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Balti, I., Barrère, A., Gueguen, V. et al. Preparation of cytocompatible luminescent and magnetic nanohybrids based on ZnO, Zn0.95Ni0.05O and core@shell ZnO@Fe2O3 polymer grafted nanoparticles for biomedical imaging. J Nanopart Res 14, 1266 (2012). https://doi.org/10.1007/s11051-012-1266-x

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