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Instant and supersaturated dissolution of naproxen and sesamin (poorly water-soluble drugs and supplements) nanoparticles prepared by continuous expansion of liquid carbon dioxide solution through long dielectric nozzle

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Abstract

Nanoparticles (NPs) of naproxen (a nonsteroidal anti-inflammatory drug, BCS Class 2) and sesamin (a poorly water-soluble lignan) were investigated. By applying a newly developed rapid expansion system of liquid carbon dioxide solutions equipped with a dielectric nozzle, well-separated and fine both naproxen NPs (averaged particle size (APS) = 46.9 nm) and sesamin NPs (APS = 60.2 nm) were obtained without heating, surfactants, and co-solvents. Obtained naproxen and sesamin NPs had large surface/weight ratio, therefore, they showed instant dissolution to water until about ten percent higher than the saturated concentrations. In addition, the technique developed in the study has big advantage on producing especially drug NPs because the NPs produced by the method never includes neither poisonous additives (especially co-solvents and detergents) nor thermally denatured compounds.

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Acknowledgments

This study was supported by a Scientific Research Grant from the Ministry of Education, Science, Sports, and Culture of Japan. TA thanks grant-in-aid for Challenging Exploratory Research No. 24655113 for their financial support. The authors thank Prof. H. Yabu (IMRAM, Tohoku University) for his advice on SEM measurement.

Conflicts of interest

The authors report no conflicts of interest in this study.

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Authors and Affiliations

  1. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Aoba-ku, Sendai, 980-8577, Japan

    Toshihiko Arita

  2. Graduate School of Engineering, Tohoku University, 6-6 Aramakiaoba, Aoba-ku, Sendai, 980-8579, Japan

    Noriyoshi Manabe

  3. Frontier Center for Value Creation, Suntory Bussiness Expert Limited, 5-2-5 Yamazaki, Shimamoto-cho, Mishima-gun, Osaka, 618-0001, Japan

    Koichi Nakahara

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  1. Toshihiko Arita
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  2. Noriyoshi Manabe
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Correspondence to Toshihiko Arita.

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Arita, T., Manabe, N. & Nakahara, K. Instant and supersaturated dissolution of naproxen and sesamin (poorly water-soluble drugs and supplements) nanoparticles prepared by continuous expansion of liquid carbon dioxide solution through long dielectric nozzle. J Nanopart Res 14, 1251 (2012). https://doi.org/10.1007/s11051-012-1251-4

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