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Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer

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Abstract

Naproxen (NPX) drug-loaded magnetic nanoparticles (MNPs) have been prepared in a one-step process utilizing a biocompatible polylactide-grafted-chitosan copolymer. The copolymer serves both as a NPX drug carrier as well as a polymeric surfactant for the synthesis of MNPs without the use of any additional surfactant. Highly stable MNPs with high magnetization in the form of maghemite (γ-Fe2O3) are prepared in aqueous media. Effects of preparation conditions on structures and properties of the copolymer-coated and drug-loaded MNPs are investigated by employing particle size and zeta potential measurements, transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction, Fourier-transform infrared, nuclear magnetic resonance, and confocal Raman spectroscopy. The results show that average particle size (150–300 nm), coating efficiency, and coating structures of the resulting MNPs materials are strongly dependent on MNP/copolymer and MNP/NPX ratios in feed. It is also observed that NPX acts as co-surfactant in the drug-loading process, resulting in different encapsulating structures with the variation in the MNP/copolymer and MNP/NPX ratios. Properties of the MNPs materials can be further optimized for use in specific biomedical applications.

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Acknowledgments

This study is supported by the National Research University Project of Thailand, Office of Higher Education Commission. Financial support provided from The Thailand Research Fund/Thailand Office of Higher Education Commission (RTA5480007) to P.T., is gratefully acknowledged. C.T. thanks the support from SIIT, Thammasat University. The authors are also grateful to P. Jantaratana for his magnetization set-up and measurements.

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Authors and Affiliations

  1. School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, Pathum Thani, 12121, Thailand

    C. Thammawong, P. Sreearunothai & P. Opaprakasit

  2. National Metal and Materials Technology Center (MTEC), Thailand Science Park, Pathum Thani, 12120, Thailand

    A. Petchsuk

  3. Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand

    P. Tangboriboonrat

  4. National Nanotechnology Center (NANOTEC), Thailand Science Park, Pathum Thani, 12120, Thailand

    N. Pimpha

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  1. C. Thammawong
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  2. P. Sreearunothai
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  3. A. Petchsuk
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  4. P. Tangboriboonrat
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  5. N. Pimpha
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  6. P. Opaprakasit
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Correspondence to P. Opaprakasit.

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Thammawong, C., Sreearunothai, P., Petchsuk, A. et al. Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer. J Nanopart Res 14, 1046 (2012). https://doi.org/10.1007/s11051-012-1046-7

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