Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities

  • Lourdes I. CabreraEmail author
  • Álvaro Somoza
  • José F. Marco
  • Carlos J. Serna
  • M. Puerto Morales
Research Paper


Cubic monodisperse MFe2O4 ferrite nanoparticles (M = Fe, Co, and Mn) with tunable sizes between 7 and 20 nm and a narrow size distribution have been achieved in a one step synthesis by thermal decomposition of Fe(III), Co (II), and Mn(II) oleates. These nanoparticles have been functionalized with dimercaptosuccinic acid (DMSA), 11-mercaptoundecanoic acid (MUA), and bis(carboxymethyl)(2-maleimidylethyl)ammonium 4-toluenesulfonate (MATS) to grant them aqueous stability and the possibility for further functionalization with different biomolecules. Their structural, magnetic, and colloidal properties have also been studied to determine their chemical and physical properties and the degree of stability under physiological conditions that will determine their future use in biomedical applications.


Ferrites Nanoparticles Thermal decomposition 





Dimercaptosuccinic acid: DMSA: 11-mercaptoundecanoic acid


bis(carboxymethyl)(2-maleimidylethyl)ammonium 4-toluenesulfonate


Deoxyribonucleic acid


Ribonucleic acid


Reticuloendothelial system


Revolutions per minute


Dimethyl sulfoxide


Potassium hydroxide


Nitric acid




Inductively coupled plasma optical emission spectrometry


Transmission electron microscopy


Thermal gravimetric analysis


Fourier transform infrared


X-ray diffraction


Dynamic light scattering


Phosphate buffered saline


Iron (III) oleate


Manganese (II) oleate


Cobalt (II) oleate




Remanent magnetization


Saturation magnetic moment


Room temperature




Point of zero charge



This work was supported by the Spanish Ministry of Science and Innovation (MAT2008-01489 to SVV MAT2009-14578-C03-01 for JFM, MAT2011-23641 to MPM, and CSD2007-00010 to MPM) and the Regional Government from Madrid (S009/MAT-1726 to MPM).


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Lourdes I. Cabrera
    • 1
    • 4
    Email author
  • Álvaro Somoza
    • 2
  • José F. Marco
    • 3
  • Carlos J. Serna
    • 1
  • M. Puerto Morales
    • 1
  1. 1.Instituto de Ciencia de Materiales de Madrid, CSICMadridSpain
  2. 2.Faculty of Science Module C-IX, Instituto Madrileño de Estudios Avanzados-NanocienciaMadridSpain
  3. 3.Instituto de Química-Física “ROCASOLANO”, CSICMadridSpain
  4. 4.LA.M.M. c/o dipartimento di ChimicaUniversità degli Studi di FirenzeSesto (Fi)Italy

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