Journal of Nanoparticle Research

, Volume 13, Issue 3, pp 1253–1264 | Cite as

Controlled release of ketorolac through nanocomposite films of hydrogel and LDH nanoparticles

Research Paper

Abstract

A novel nanocomposite film for sustained release of anionic ophthalmic drugs through a double-control process has been examined in this study. The film, made as a drug-loaded contact lens, consists principally of a polymer hydrogel of 2-hydroxyethyl methacrylate (HEMA), in whose matrix MgAl-layered double hydroxide (MgAl-LDH) nanoparticles intercalated with the anionic drug are well dispersed. Such nanocomposite films (hydrogel-LDH-drug) contained 0.6–0.8 mg of MgAl-LDH and 0.08–0.09 mg of the ophthalmic drug (ketorolac) in 1.0 g of hydrogel. MgAl-drug-LDH nanoparticles were prepared with the hydrodynamic particle size of 40–200 nm. TEM images show that these nanoparticles are evenly dispersed in the hydrogel matrix. In vitro release tests of hydrogel-LDH-drug in pH 7.4 PBS solution at 32 °C indicate a sustained release profile of the loaded drug for 1 week. The drug release undergoes a rapid initial burst and then a monotonically decreasing rate up to 168 h. The initial burst release is determined by the film thickness and the polymerization conditions, but the following release rate is very similar, with the effective diffusion coefficient being nearly constant (3.0 × 10−12 m2/s). The drug release from the films is mechanistically attributed to anionic exchange and the subsequent diffusion in the hydrogel matrix.

Keywords

Layered double hydroxide nanoparticles Double-control release Nanocomposite contact lens Hydrogel Ketorolac Sustained release Drug delivery 

Supplementary material

11051_2010_118_MOESM1_ESM.doc (359 kb)
Supplementary material 1 (DOC 359 kb)

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Australian Institute for Bioengineering and Nanotechnology, ARC Centre of Excellence for Functional Nanomaterials, The University of QueenslandBrisbaneAustralia
  2. 2.Centre for Advanced Imaging and Australian Institute for Bioengineering and Nanotechnology, The University of QueenslandBrisbaneAustralia

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