Abstract
Micronutrient malnutrition is widespread and constitutes one of the main nutritional problems worldwide. Vitamins, amino acids, carbohydrates and Ca-phosphate (CaP) minerals are important to human health and disease prevention. Herein we developed a simple wet-chemical method to prepare multinary nutrients-containing CaP nanomaterials in diluted apple, orange, and grape juices. The scanning electron microscopy observation shows that these nanomaterials are short plate-like CaP nanocrystals of ~500 nm in length. The X-ray photoelectron spectroscopy, nitrogen adsorption, thermogravimetric analyses confirm the different specific surface area and organic nutrient contents. The Fourier transform infrared and X-ray diffraction analyses indicate there exist similar organic groups (i.e., COO−, HN-CO) but different CaP species in the precipitates. The dissolution test in vitro simulated stomach juice pH condition indicates that these inorganic–organic nanohybrid materials are multidoped by micronutrients (such as Zn, Sr, Mg, K, vitamin c) and can be readily dissolved in the weak acidic aqueous solutions. This highly efficient utilization of fruit juice to produce CaP-based micronutrient composites may minimize the adverse side effect, so that the nanomaterials are promising as functional food/drink additives. Thus, this novel approach is environmentally and biologically friendly to produce edible nutrients while production cost is attained.
Similar content being viewed by others
References
Alvarez WC (1938) Problems of maintaining nutrition in the highly food-sensitive person. Am J Digest Dis 5:801–803
Anema SA (2009) Role of colloidal calcium phosphate in the acid gelation properties of heated skim milk. Food Chem 114:161–167
Arifuzzaman SM, Rohani S (2004) Experimental study of brushite precipitation. J Cryst Growth 267:624–634
Balluz LS, Philen SM, Mulinare J (2000) Vitamin and mineral supplement use in the United States. Arch Fam Med 9:258–262
Benoit DSW, Schwartz MP, Durney AR, Anseth KS (2008) Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cell. Nat Mater 7:816–823
Bigi A, Boanini E, Falini G, Panzavolta S, Roveri N (2000) Effect of sodium polyacrylate on the hydrolysis of octacalcium phosphate. J Inorg Biochem 78:227–233
Bigi A, Panzavolta S, Rubini K (2004) Setting mechanism of a biomimetic bone cement. Chem Mater 16:3740–3745
Cai W, Yu J, Cheng B, Su B-L, Jaroniec M (2009) Synthesis of boehmite hollow core/shell and hollow microspheres via sodium tartrate-mediated phase transformation and their enhanced adsorption performance in water treatment. J Phys Chem C 113:14739–124746
Castilla P, Echarri R, Dávalos A, Cerrato F, Ortega H, Teruel J, Lucas MF, Gómez-Coronado D, Ortuño J, Lasunción MA (2006) Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr 84:252–262
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ (1992) Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327:1637–1642
Deyhim F, Mandadi K, Faraji B, Patil BS (2008) Grapefruit juice modulates bone quality in rats. J Med Food 11:99–104
Dorothee V (2002) Malnutrition in the elderly-prevalence, causes and corrective strategies. Clin Nutr 21:110–112
Dorozhkin SV, Epple M (2002) Biological and medical significance of calcium phosphates. Angew Chem Int Ed 41:3130–3146
Dvorak MM, Siddiqua A, Ward DT, Carter DH, Dallas SL, Nemeth EF (2004) Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci USA 101:5140–5145
Eiden-Aßmann S, Vietelhaus M, Heiß A, Hoetzer KA, Felsche J (2002) The influence of amino acids on the biomineralization of hydroxyapatite in gelatin. J Inorg Biochem 91:481–486
Foo SY, Heller ER, Wykrzykowska J, Sullivan CJ, Manning-Tobin JJ, Moore KJ, Gerszten RE, Rosenzweig A (2009) Vascular effects of a low-carbohydrate high-protein diet. Proc Natl Acad Sci USA 106:15418–15426
Fowler BO, Marković M, Brown WE (1993) Octacalcium phosphate. 3. Infrared and Raman vibrational spectra. Chem Mater 5:1417–1423
Gou Z, Yang X, Gao X, Zhang X, Ting K, Wu BM, Gao C (2009) Octacalcium phosphate microscopic superstructure self-assembly and evolution by dual-mediating combination. CrystEngComm 11:1585–1591
Gower LB, Odom DJ (2000) Deposition of calcium carbonate films by a polymer-induced liquid-precursor (PILP) process. J Cryst Growth 210:719–734
Gray JJ (2004) The interaction of proteins with solid surfaces. Curr Opin Struct Biol 14:110–115
Heaney RP (2004) Phosphorus nutrition and the treatment of osteoporosis. Mayo Clin Proc 79:91–97
Heaney RP, Nordin BE (2002) Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. J Am Coll Nutr 21:239–244
Hyson D, Studebaker-Hallman D, Davis PA, Gershwin ME (2000) Apple juice consumption reduces plasma low-density lipoprotein oxidation in healthy men and women. J Med Food 2:159–166
Keen CL, Clegg MS, Hanna LA, Lanoue L, Rogers JM, Daston GP, Oteiza P, Uriu-Adams YJY (2003) The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr 133:1597S–1605S
Keselowshy BG, Collard DM, Garcia AJ (2005) Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc Natl Acad Sci USA 102:5953–5957
Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piché LA, Serratore P (2000) HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 72:1095–1100
Larsen MJ, Nyvad B (1999) Enamel erosion by some soft drinks and orange juices relative to their pH, buffering effect and contents of calcium phosphate. Caries Res 33:81–87
LeGeros RZ (2001) Formation and transformation of calcium phosphates: relevance to vascular calcification. Z. Kardiol 90: Suppl 3. III/116–124
Liena C, Forner L, Baca P (20090 Anticariogenicity of casein phospho-peptide-amorphous calcium phosphate: a review of the literature. J Contemp Dent Pract 10: 1–9
Masumoto T, Okazaki M, Inoue M, Hamada Y, Taira M, Takahashi J (2002) Crystallinity and solubility characteristics of hydroxyapatite adsorbed amino acid. Biomaterials 23:2241–2247
Morgan TT, Muddana HS, Altinoğlu EI, Rouse SM, Tabaković A (2008) Encapsulation of organic molecules in calcium phosphate nanocomposites particles for intracellular imaging and drug delivery. Nano Lett 8:4108–4115
Pan HB, Darell BW (2009) Calcium phosphate solubility: the need for re-evaluation. Cryst Growth Des 9:639–645
Pezzuto JM (2008) Grape and human health: a perspective. J Agric Food Chem 56:6777–6784
Sakamoto K, Yamaguchi S, Kaneno M, Fujihara I, Satoh K, Tsunawaki Y (2008) Synthesis and thermal decomposition of layered calcium phosphates including carboxylate ions. Thin Solid Film 517:1354–1357
Sing KSW, Everett DH, Haul RAW, Moscou L, Pierotti RA, Rouquerol J, Siemiewska T (1985) Reporting physisorption data for gas/solid systems. Pure Appl Chem 57:603–619
Spanos N, Partis A, Kanellopoulou D, Andritsos N, Koutsoukos PG (2007) Precipitation of calcium phosphate from simulated milk ultrafiltrate solutions. Cryst Growth Des 7:25–29
Tokudome Y, Otsuo M, Ito A, LeGeros RZ (2009) Long-term therapeutic effect of novel calcium phosphate-based compounds injected in ovariectomized rats. J Biomed Mater Res B 90B:229–237
Tung MS, Eirchmiller FC (1999) Dental applications of amorphous calcium phosphates. J Clin Dent 10:1–6
Uauy R, Kain J, Mericq V, Rojas J, Covalan C (2008) Nutrition, child growth, and chronic disease prevention. Ann Med 40:11–20
Wilson CJ, Cleff RE, Leavesley AI, Pearcy MJ (2005) Mediation of biomaterial–cell interactions by adsorbed proteins: a review. Tissue Eng 11:1–17
World Health Organization (2001) The World Health Report 2001: reducing risks, promoting healthy life. World Health Organization, Geneva, Switzerland
World Health Organization (2005) Multiple vitamin and mineral supplements for pregnant and lactating women, and for children aged 6 to 59 months. World Health Organization, Geneva, Switzerland
Yang X, Gao X, Gan Y, Gao C, Zhang X, Ting K, Wu BM, Gou Z (2010) Facile synthesis of octacalcium phosphate nanobelts: growth mechanism and surface adsorption properties. J Phys Chem C 114:6265–6271
Young JF, Nielsen SE, Haraldsdóttir J, Daneshvar B, Lauridsen ST, Knuthsen P, Crozier A, Sandström B, Dragsted LO (1999) Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. Am J Clin Nutr 69:87–94
Acknowledgments
The authors would like to acknowledge financial support from the National Science of Foundation of China (No. 50902121), Zhejiang University-Wenzhou Science and Technology Bureau Co-foundation (H20080039) and the Fundamental Research Funds for the Central Universities (No. KYJD09027). We acknowledge Dr. J. Feng and Dr. J. Gu for XPS and nitrogen sorption measurements.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Wang, J., Chen, X., Yang, X. et al. A facile pollutant-free approach toward a series of nutritionally effective calcium phosphate nanomaterials for food and drink additives. J Nanopart Res 13, 1039–1048 (2011). https://doi.org/10.1007/s11051-010-0092-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11051-010-0092-2