Journal of Nanoparticle Research

, Volume 11, Issue 7, pp 1637–1650 | Cite as

Relevance of aerosol dynamics and dustiness for personal exposure to manufactured nanoparticles

Special Issue: Environmental and human exposure of nanomaterials


Production and handling of manufactured nanoparticles (MNP) may result in unwanted worker exposure. The size distribution and structure of MNP in the breathing zone of workers will differ from the primary MNP produced. Homogeneous coagulation, scavenging by background aerosols, and surface deposition losses are determinants of this change during transport from source to the breathing zone, and to a degree depending on the relative time scale of these processes. Modeling and experimental studies suggest that in MNP production scenarios, workers are most likely exposed to MNP agglomerates or MNP attached to other particles. Surfaces can become contaminated by MNP, which constitute potential secondary sources of airborne MNP-containing particles. Dustiness testing can provide insight into the state of agglomeration of particles released during handling of bulk MNP powder. Test results, supported by field data, suggest that the particles released from powder handling occur in distinct size modes and that the smallest mode can be expected to have a geometric mean diameter >100 nm. The dominating presence of MNP agglomerates or MNP attached to background particles in the air during production and use of MNP implies that size alone cannot, in general, be used to demonstrate presence or absence of MNP in the breathing zone of workers. The entire respirable size fraction should be assessed for risk from inhalation exposure to MNP.


Agglomerate Coagulation Dustiness EHS Exposure Nanoparticles Occupational health Surface deposition 


  1. Andreasen AHM, Hofman-Bang N, Rasmussen NH (1939) Über das Stäubungsvermögen der Stoffe (The dust generating capacity of materials). Colloid Polym Sci 86(1):70–77Google Scholar
  2. Ayer HE, Yeager DW (1982) Irritants in cigarette smoke plumes. Am J Public Health 72:1283–1285PubMedCrossRefGoogle Scholar
  3. Bach S, Schmidt E (2008) Determining the dustiness of powders—a comparison of three measuring devices. Ann Occup Hyg 52:717–725PubMedCrossRefGoogle Scholar
  4. Baron PA, Maynard AD, Foley M (2003) Evaluation of aerosol release during the handling of unrefined single walled carbon nanotube material. NIOSH, Cincinnati, USAGoogle Scholar
  5. Bierman MJ, Lau YKA, Jin S (2007) Hyperbranched PbS and PbSe nanowires and the effect of hydrogen gas on their synthesis. Nano Lett 7:2907–2912PubMedCrossRefADSGoogle Scholar
  6. Brockel U, Wahl M, Kirsch R et al (2006) Formation and growth of crystal bridges in bulk solids. Chem Eng Technol 29:691–695CrossRefGoogle Scholar
  7. Brouwer DH, Links IH, de Vreede SA et al (2006) Size selective dustiness and exposure; simulated workplace comparisons. Ann Occup Hyg 50:445–452PubMedCrossRefGoogle Scholar
  8. CEN (2006) EN 15051 Workplace atmospheres—measurement of the dustiness of bulk materials—requirements and test methods. Comité Européen de Normalisation, Brussels, BelgiumGoogle Scholar
  9. Chen F, Lai ACK (2004) An Eulerian model for particle deposition under electrostatic and turbulent conditions. J Aerosol Sci 35:47–62CrossRefGoogle Scholar
  10. Cowherd C, Grelinger MA, Wong KF (1989) Dust inhalation exposures from the handling of small volumes of powders. Am Ind Hyg Assoc J 50:131–138PubMedGoogle Scholar
  11. Crump JG, Seinfeld JH (1981) Turbulent deposition and gravitational sedimentation of an aerosol in a vessel of arbitrary shape. J Aerosol Sci 12:405–415CrossRefGoogle Scholar
  12. Davies KM, Hammond CM, Higman RW et al (1988) Progress in dustiness estimation: British Occupational Hygiene Society Technology Committee Working Party on Dustiness Estimation. Ann Occup Hyg 32:535–544CrossRefGoogle Scholar
  13. Debrincat DP, Solnordal CB, Van Deventer JSJ (2008) Characterisation of inter-particle forces within agglomerated metallurgical powders. Powder Technol 182:388–397CrossRefGoogle Scholar
  14. Endo Y, Hasebe S, Kousaka Y (1997) Dispersion of aggregates of fine powder by acceleration in an air stream and its application to the evaluation of adhesion between particles. Powder Technol 91:25–30CrossRefGoogle Scholar
  15. Gbureck U, Dembski S, Thull R et al (2005) Factors influencing calcium phosphate cement shelf-life. Biomaterials 26:3691–3697PubMedCrossRefGoogle Scholar
  16. Gill TE, Zobeck TM, Stout JE (2006) Technologies for laboratory generation of dust from geological materials. J Hazard Mater 132:1–13PubMedCrossRefGoogle Scholar
  17. Gong L, Xu B, Zhu Y (2009) Ultrafine particles deposition inside passenger vehicles. Aerosol Sci Technol 43:544–553CrossRefGoogle Scholar
  18. Heitbrink WA, Todd WF, Fischbach TJ (1989) Correlation of tests for material dustiness with worker exposure from bagging of powders. Appl Ind Hyg 4:12–16Google Scholar
  19. Heitbrink WA, Todd WF, Cooper TC et al (1990) The application of dustiness tests to the prediction of worker dust exposure. Am Ind Hyg Assoc J 51:217–223PubMedGoogle Scholar
  20. HSE (1996) MDHS 81 Dustiness of powders and materials. Health and Safety Executive, UKGoogle Scholar
  21. Ibaseta N (2007) Etude experimentale et modelisation de l’emission d’aerosols ultrafins lors du deversement de poudres nanostructures. Thesis. Institut national polytechniques de Toulouse, France.
  22. Jacobson MZ, Seinfeld JH (2004) Evolution of nanoparticle size and mixing state near the point of emission. Atmos Environ 38:1839–1850CrossRefGoogle Scholar
  23. Jensen KA, Koponen IK, Clausen PA et al (2009) Dustiness behaviour of loose and compacted Bentonite and organoclay powders: what is the difference in exposure risk? J Nanopart Res 11:133–146CrossRefGoogle Scholar
  24. Kousaka Y, Okuyama K, Endo Y (1980) Re-entrainment of small aggregate particles from a plane surface by air stream. J Chem Eng Japan 13:143–147CrossRefGoogle Scholar
  25. Kuhlbusch AJ, Rating U, van der Zwaag T et al (2008) Modelling of physical processes during dispersion of nanoparticles from a leak. European Aerosol Conference 2008, Thessaloniki, Abstract T01A023OGoogle Scholar
  26. Lai AC (2002) Particle deposition indoors: a review. Indoor Air 12:211–214PubMedCrossRefGoogle Scholar
  27. Lai ACK, Chen F (2006) Modeling particle deposition and distribution in a chamber with a two-equation Reynolds-averaged Navier-Stokes model. J Aerosol Sci 37:1770–1780CrossRefMathSciNetGoogle Scholar
  28. Lai K, Nazaroff WW (2000) Modeling indoor particle deposition from turbulent flow onto smooth surfaces. J Aerosol Sci 31:463–476CrossRefGoogle Scholar
  29. Li WI, Edwards DA (1997) Aerosol particle transport and deaggregation phenomena in the mouth and throat. Adv Drug Deliv Rev 26:41–49PubMedCrossRefGoogle Scholar
  30. Luther W (2004) Industrial applications of nanomaterials—chances and risks. Future technologies No. 54. VDI Technologiezentrum GmbH, Düsseldorf, GermanyGoogle Scholar
  31. Maynard AD (2002) Experimental determination of ultrafine TiO2 deagglomeration in a surrogate pulmonary surfactant: Preliminary results. Ann Occup Hyg 46(Suppl 1):197–202Google Scholar
  32. Maynard AD, Zimmer AT (2003) Development and validation of a simple numerical model for estimating workplace aerosol size distribution evolution through coagulation, settling, and diffusion. Aerosol Sci Technol 37:804–817CrossRefGoogle Scholar
  33. Maynard AD, Baron PA, Foley M et al (2004) Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 67:87–107PubMedCrossRefGoogle Scholar
  34. McMurry PH, Rader DJ (1985) Aerosol wall losses in electrically charged chambers. Aerosol Sci Technol 4:249–268CrossRefGoogle Scholar
  35. Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839PubMedCrossRefGoogle Scholar
  36. Petavratzi E, Kingman SW, Lowndes IS (2007) Assessment of the dustiness and the dust liberation mechanisms of limestone quarry operations. Chem Eng Process 46:1412–1423Google Scholar
  37. Plinke MAE, Leith D, Hathaway R et al (1994) Cohesion in granular materials. Bulk Solids Handling 14:101–106Google Scholar
  38. Qian J, Ferro AR (2008) Resuspension of dust particles in a chamber and associated environmental factors. Aerosol Sci Technol 42:566–578CrossRefGoogle Scholar
  39. Schneider T, Jensen KA (2008) Combined single-drop and rotating drum dustiness test of fine to nanosize powders using a small drum. Ann Occup Hyg 52:23–34PubMedCrossRefGoogle Scholar
  40. Seipenbusch M, Binder A, Kasper G (2008) Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg 52:707–716PubMedCrossRefGoogle Scholar
  41. Sethi SA, Schneider T (1996) A gas fluidization dustiness tester. J Aerosol Sci 27(Suppl 1):S305–S306CrossRefGoogle Scholar
  42. Shafer EGE, Wollish EG, Engel CE (1956) The “Roche” friabilator. J Am Pharm Assoc 45:114–116Google Scholar
  43. Spagnoli D, Banfield JF, Parker SC (2008) Free energy change of aggregation of nanoparticles. J Phys Chem C 112:14731–14736CrossRefGoogle Scholar
  44. Stahlmecke BG, Asbach C, Kaminski H et al (2008) Agglomerate stability of nanopowders. European Aerosol Conference 2008, Thessaloniki, Abstract T01A029OGoogle Scholar
  45. Szepvolgyi J, Mohai I, Gubicza J (2001) Atmospheric ageing of nanosized silicon nitride powders. J Mater Chem 11:859–863CrossRefGoogle Scholar
  46. Tielemans E, Schneider T, Goede H et al (2008) Conceptual model for assessment of inhalation exposure: defining modifying factors. Ann Occup Hyg 52:577–586PubMedCrossRefGoogle Scholar
  47. Tomas J (2007) Adhesion of ultrafine particles—a micromechanical approach. Chem Eng Sci 62:1997–2010CrossRefGoogle Scholar
  48. Tsai S-J, Ashter A, Ada E et al (2008a) Control of airborne nanoparticles release during compounding of polymer nanocomposites. NANO 3(4):301–309CrossRefGoogle Scholar
  49. Tsai S-J, Ada E, Isaacs JA et al (2008b) Airborne nanoparticle release associated with the manual handling of nanoalumina and nanosilver in fume hoods. J Nanopart Res 11:147–161CrossRefGoogle Scholar
  50. Tsai C-J, Wu C-H, Leu M-L et al (2008c) Dustiness test of nanopowders using a standard rotating drum with a modified sampling train. J Nanopart Res 11:121–131CrossRefGoogle Scholar
  51. Wahl M, Bröckel U, Brendel L et al (2008) Understanding powder caking: predicting caking strength from individual particle contacts. Powder Technol 188:147–152CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.National Research Centre for the Working EnvironmentCopenhagenDenmark

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