Journal of Nanoparticle Research

, Volume 11, Issue 6, pp 1509–1512 | Cite as

Silicon nitride nanoparticles for surface-assisted laser desorption/ionization of small molecules

  • Mohammadreza Shariatgorji
  • Nahid Amini
  • Leopold L. Ilag
Brief Communication

Abstract

Conventional matrix-assisted laser desorption/ionization mass spectrometry is limited to analyses of higher molecular weight compounds due to high background noise generated by the matrix in the lower mass region. Surface-assisted laser desorption/ionization (SALDI) mass spectrometry is an alternative solution to this problem. Nanoparticles, structured silicon surfaces and carbon allotropes are commonly used as SALDI surfaces. Here, for the first time, we demonstrate the application of silicon nitride nanoparticles as a suitable medium for laser desorption/ionization of small drug molecules.

Keywords

Silicon nitride nanoparticles Surface-assisted laser desorption/ionization mass spectrometry Small molecules 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Mohammadreza Shariatgorji
    • 1
  • Nahid Amini
    • 1
  • Leopold L. Ilag
    • 1
  1. 1.Department of Analytical ChemistryStockholm UniversityStockholmSweden

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