Journal of Nanoparticle Research

, Volume 11, Issue 4, pp 909–916

Preparation and characterization of smart polymer brush-modified magnetic nanoparticles for biomedicine application

Research Paper

DOI: 10.1007/s11051-008-9481-1

Cite this article as:
Wang, S., Zhou, Y., Guan, W. et al. J Nanopart Res (2009) 11: 909. doi:10.1007/s11051-008-9481-1


This paper investigates synthesis and characterization of smart polymer brush-modified magnetic nanoparticles (SPB-MNPs). Magnetic nanoparticles (MNPs) modified with poly(poly(ethylene glycol) monomethacrylate (poly(PEGMA)) brush were first functioned with activated pyridyldithio. Then, MNPs functioned with pyridyldithio (MNPs-PEG-PDT) were conjugated with 4-diamino-6-mercaptopyrimidine (DMP) to form SPB-MNPs via stimuli-responsive disulfide linkage. Fourier transform infrared spectra (FTIR) was used to monitor the preparation process of MNPs-PEG-PDT. MNPs-PEG-PDT is very highly reactive toward DMP. The disulfide linkage of SPB-MNPs can be cleaved by reduced glutathione (GHS). The concentration of GHS plays an important role in controlling the cleaved efficiency. The optimum concentration of GHS to release DMP is in the millimolar range.


Magnetic nanoparticles Disulfide linkage Liable Glutathione Smart Synthesis 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Shixing Wang
    • 1
    • 2
  • Yang Zhou
    • 1
    • 2
  • Wen Guan
    • 1
  • Bingjun Ding
    • 1
  1. 1.School of ScienceXi’an Jiaotong UniversityShanxiChina
  2. 2.The National Center for Nanoscience and TechnologyBeijingChina

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