Journal of Nanoparticle Research

, Volume 10, Issue 3, pp 465–473 | Cite as

Foam droplet separation for nanoparticle synthesis

  • Corey A. Tyree
  • Jonathan O. AllenEmail author
Research Paper


A novel approach to nanoparticle synthesis was developed whereby foam bubble bursting produced aerosol droplets, an approach patterned after the marine foam aerosol cycle. The droplets were dried to remove solvent, leaving nanometer-sized particles composed of precursor material. Nanoparticles composed of sodium chloride (mean diameter, \(\bar{D}_{\rm p}\approx\) 100 nm), phosphotungstic acid (\(\bar{D}_{\rm p}\approx\) 55 nm), and bovine insulin (\({D}_{\rm p}\approx\) 5–30 nm) were synthesized. Foam droplet separation can be carried out at ambient temperature and pressure. The ‘soft’ nature of the process makes it compatible with a wide range of materials.


Nanoparticle Insulin Polyoxometalate Inhalation aerosol Foam Particle synthesis 



We thank John C. Crittenden (Arizona State University) and Daniel A. Gonzales (ASU) for helpful discussions. We thank Brian Parkey (ASU) for carrying out the protein assays. We gratefully acknowledge the use of the facilities at the John M. Cowley Center for High Resolution Electron Microscopy within the Center for Solid State Science at ASU. We also thank Karl Weiss (ASU) and Matthew E. Wise (ASU) for their guidance on TEM and EDS analysis. CAT was partially supported by a Phoenix Achievement Reward for College Scientists (ARCS) Foundation Scholarship.


  1. Blanchard DC (1963) The electrification of the atmosphere by particles from bubbles in the sea. In: Sears M (ed) Progress in Oceanography vol 1. Pergamon Press, New York, pp 73–202Google Scholar
  2. Blanchard DC (1975) Bubble scavenging and the water-to-air transfer of organic material in the sea. In: Baier RE (ed) Applied Chemistry at Protein Interfaces. ACS Adv Chem Ser 145:360–387Google Scholar
  3. Blanchard DC (1989) The ejection of drops from the sea and their enrichment with bacteria and other materials: a review. Estuaries 12:127–137CrossRefGoogle Scholar
  4. Bore MT, Rathod SB, Ward TL, Datye AK (2003) Hexagonal mesostructure in powders produced by evaporation-induced self-assembly of aerosols from aqueous tetraethoxysilane solutions. Langmuir 19:256–264CrossRefGoogle Scholar
  5. Clarke AD, Kapustin V, Howell S, Moore K, Lienert B, Masonis S, Anderson T, Covert D (2003) Sea-salt size distributions from breaking waves: implications for marine aerosol production and optical extinction measurements during SEAS. J Atmos Oceanic Technol 20:1362–1374CrossRefGoogle Scholar
  6. Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Reynolds CD, Smith GD, Sparks C, Swenson D (1989) Phenol stabilizes more helix in a symmetrical zinc insulin hexamer. Nature 338:594–596CrossRefGoogle Scholar
  7. Gkika E, Troupis A, Hiskia A, Papaconstantinou E (2005) Photocatalytic reduction and recovery of mercury by polyoxometalates. Environ Sci Technol 39:4242–4248CrossRefGoogle Scholar
  8. Gomez A, Bingham D, de Juan L, Tang K (1998) Production of protein nanoparticles by electrospray drying. J Aerosol Sci 29:561–574CrossRefGoogle Scholar
  9. Guo YH, Hu CW (2003) Porous hybrid photocatalysts based on polyoxometalates. J Cluster Sci 14:505–526CrossRefGoogle Scholar
  10. Hinds WC (1999) Aerosol Technology 2nd edn. John Wiley & Sons, New YorkGoogle Scholar
  11. Keene WC, Pszenny AAP, Galloway JN, Hawley ME (1986) Sea-salt corrections and interpretation of constituent ratios in marine precipitation. J Geophys Res 91:6647–6658Google Scholar
  12. Koo DH, Kim M, Chang S (2005) WO3 nanoparticles on MCM-48 as a highly selective and versatile heterogeneous catalyst for the oxidation of olefins, sulfides, and cyclic ketones. Org Lett 7:5015–5018CrossRefGoogle Scholar
  13. Kozhevnikov IV (2001) Catalysts for Fine Chemical Synthesis vol 2. John Wiley & Sons, West Sussex, EnglandGoogle Scholar
  14. Kreidenweis SM, McInnes LM, Brechtel FJ (1998) Observations of aerosol volatility and elemental composition at MacQuarie Island during the first Aerosol Characterization Experiment (ACE 1). J Geophys Res 103:16,511–16,524CrossRefGoogle Scholar
  15. Kreuter J (2001) Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47:65–81CrossRefGoogle Scholar
  16. Kruis FE, Fissan H, Peled A (1998) Synthesis of nanoparticles in the gas phase for electronic, optical and magnetic applications —a review. J Aerosol Sci 29:511–535CrossRefGoogle Scholar
  17. Kurth DG, Lehmann P, Volkmer D, Cölfen H, Koop MJ, Müller A, Du Chesne A (2000) Surfactant-encapsulated clusters (SECs): (DODA20)(NH4)[H3Mo57V6(NO)6O183(H2O)18], a case study. Chem Eur J 6: 385–393CrossRefGoogle Scholar
  18. Laube BL (2001) Treating diabetes with aerosolized insulin. Chest 120:99S–106SCrossRefGoogle Scholar
  19. Lee KY, Arai T, Nakata S, Asaoka S, Okuhara T, Misono M (1992) Catalysis by heteropoly compounds 20. An NMR study of ethanol dehydration in the pseudoliquid phase of 12-tungstophosphoric acid. J Am Chem Soc 114:2836–2842CrossRefGoogle Scholar
  20. Lewis ER, Schwartz SE (2004) Sea salt aerosol production: mechanisms, methods, measurements, and models. AGU, Washington, DCGoogle Scholar
  21. Lu YF, Fan HY, Stump A, Ward TL, Rieker T, Brinker CJ (1999) Aerosol-assisted self-assembly of mesostructured spherical nanoparticles. Nature 398:223–226CrossRefGoogle Scholar
  22. Mårtensson EM, Nilsson ED, de Leeuw G, Cohen LH, Hansson HC (2003) Laboratory simulations and parameterization of the primary marine aerosol production. J Geophys Res 108:4297CrossRefGoogle Scholar
  23. O’Dowd CD, Smith MH (1993) Physicochemical properties of aerosols over the Northeast Atlantic: evidence for wind-speed-related submicron sea-salt aerosol production. J Geophys Res 98:1137–1149CrossRefGoogle Scholar
  24. Okuyama K, Lenggoro IW (2003) Preparation of nanoparticles via spray route. Chem Eng Sci 58:537–547CrossRefGoogle Scholar
  25. Owens DR, Zinman B, Bolli G (2003) Alternative routes of insulin delivery. Diabetic Med 20:886–898CrossRefGoogle Scholar
  26. Ozer RR, Ferry JL (2001) Investigation of the photocatalytic activity of TiO2–polyoxometalate systems. Environ Sci Technol 35:3242–3246CrossRefGoogle Scholar
  27. Patton JS, Bukar J, Nagarajan S (1999) Inhaled insulin. Adv Drug Deliv Rev 35:235–247CrossRefGoogle Scholar
  28. Sluzky V, Tamada JA, Klibanov AM, Langer R (1991) Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces. Proc Natl Acad Sci 88:9377–9381CrossRefGoogle Scholar
  29. Song CX, Labhasetwar V, Murphy H, Qu X, Humphrey WR, Shebuski RJ, Levy RJ (1997) Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Control Release 43:197–212CrossRefGoogle Scholar
  30. Stark WJ, Baiker A, Pratsinis SE (2002) Nanoparticle opportunities: pilot-scale flame synthesis of vanadia/titania catalysts. Part Part Syst Charact 19:306–311CrossRefGoogle Scholar
  31. Swihart MT (2003) Vapor-phase synthesis of nanoparticles. Curr Opin Colloid Interface Sci 8:127–133CrossRefGoogle Scholar
  32. Tyree CA, Hellion VM, Alexandrova OA, Allen JO (2007) Foam droplets generated from natural and artificial seawaters. J Geophys Res 112:D12204Google Scholar
  33. Wegner R, Pratsinis SE (2004) Flame synthesis of nanoparticles. Chim Oggi-Chem Today 22:27–29Google Scholar
  34. Woodcock AH, Kientzler CF, Arons AB, Blanchard DC (1953) Giant condensation nuclei from bursting bubbles. Nature 172:1144–1145CrossRefGoogle Scholar
  35. Yang Y, Guo Y, Hu C, Wang Y, Wang E (2004) Preparation of surface modifications of mesoporous titania with monosubstituted Keggin units and their catalytic performance for organochlorine pesticide and dyes under UV irradiation. Appl Catal A: Gen 273:201–210CrossRefGoogle Scholar
  36. Yeh HC, Cuddihy RG, Phalen RF, Chang IY (1996) Comparisons of calculated respiratory tract deposition of particles based on the proposed NCRP model and the new ICRP66 model. Aerosol Sci Technol 25:134–140CrossRefGoogle Scholar
  37. Yu J, Chien YW (1997) Pulmonary drug delivery: physiologic and mechanistic aspects. Crit Rev Ther Drug Carr Syst 14:395–453Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Department of Chemical EngineeringArizona State UniversityTempeUSA
  2. 2.Department of Civil & Environmental EngineeringArizona State UniversityTempeUSA

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