Poly(allylamine) Stabilized Iron Oxide Magnetic Nanoparticles
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This paper describes a new method for the dispersing and surface-functionalization of metal oxide magnetic nanoparticles (10 nm) with poly(allylamine) (PAA). In this approach, Fe3O4 nanoparticles, prepared with diethanolamine (DEA) as the surface capping agent in diethyleneglycol (DEG) and methanol, are ligand exchanged with PAA. This method allows the dispersing of magnetic nanoparticles into individual or small clusters of 2–5 nanoparticles in aqueous solutions. The resulting nanoparticles are water soluble and stable for months. The PAA stabilized Fe3O4 nanoparticles are characterized by TEM, TGA, and FT-IR. The PAA-coated Fe3O4 nanoparticles will allow further chemical tailoring and engineering of their surfaces for biomedical applications.
Keywordsiron oxide magnetic nanoparticles poly(allylamine) polymer coating particle dispersion surface modification clusters colloids biomedical applications
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- Acar H.Y., F.A. Syud, R.N. Garaas, P.J. Bonitatebus & A.M. Kulkarni, 2005. Contrast agents for magnetic resonance imaging. U.S. Patent 260137 A1Google Scholar
- Caruntu D., G. Caruntu, Y. Chen, G. Goloverda, C.J. O’Connor & V. Kolesnichenko, 2004. Synthesis of variable-sized nanocrystals of Fe3O4 with high surface reactivity. Chem. Mater. 16, 5527–5534. NOTE: The DEA-DEG stabilized Fe3O4 nanoparticles sample was provided from Dr. O’Connor’s research group at the University of New OrleansGoogle Scholar
- Hui S., H. Xisheng & X. Xueqing, 2006. Polymer-modified water-based magnetic liquid and preparation thereof. Patent CN 1747078 AGoogle Scholar
- Knauth M., T. Egelhof, S.U. Roth, C.R. Wirtz, K. Sartor, 2001. Monocrystalline iron oxide nanoparticles: possible solution to the problem of surgically induced intracranial contrast enhancement in intraoperative MR imaging. Am. J. Neuroradiol. 22: 99–102Google Scholar
- Lee H., Lee E., D.K. Kim, N.K. Jang, Y.Y. Jeong, S. Jon, 2006. Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging. J. Am. Chem. Soc. 128: 7393–7389Google Scholar
- Lucien Malenfant P.R., H. Acar, P.J. Bonitatebus, W.T. Dixon, & A.M. Kulkarni, 2006 Nanoparticles coated with biocompatible polymers as MRI contrast agent. U.S. Patent 018835 A1Google Scholar