Skip to main content
Log in

Efficient 3-SAT algorithms in the tile assembly model

  • Published:
Natural Computing Aims and scope Submit manuscript

Abstract

Self-assembly is a powerful process found in nature that guides simple objects assembling, on their own, into complex structures. Self-assembly is of interest to computer scientists because self-assembling systems can compute functions, assemble shapes, and guide distributed robotics systems. The tile assembly model is a formal mathematical model of self-assembly that allows the study of time and space complexities of self-assembling systems that lie at the heart of several molecular computer implementations and distributed computational software systems. These implementations and systems require efficient tile systems with small tilesets and fast execution times. The state of the art, however, requires vastly complex tile systems with large tilesets to implement fast algorithms. In this paper, I present \({\mathbb{S}}_{FS},\) a tile system that decides 3-SAT by creating \(O^{\star}(1.8393^n)\) nondeterministic assemblies in parallel, improving on the previous best known solution that requires \(\Uptheta(2^n)\) such assemblies. This solution directly improves the feasibility of building molecular 3-SAT solvers and efficiency of distributed software. I formally prove the correctness of the system, the number of required parallel assemblies, that the size of the system’s tileset is \(147 = \Uptheta(1),\) and that the assembly time is nondeterministic linear in the size of the input.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15
Fig. 16
Fig. 17

Similar content being viewed by others

References

  • Abelson H, Allen D, Coore D, Hanson C, Homsy G, Knight TF Jr, Nagpal R, Rauch E, Sussman GJ, Weiss R (2000) Amorphous computing. Commun ACM 43(5):74–82. ISSN 0001-0782. doi:10.1145/332833.332842

    Google Scholar 

  • Adleman L (2000) Towards a mathematical theory of self-assembly. Technical Report 00-722, Department of Computer Science, University of Southern California, Los Angeles, CA

  • Adleman L, Cheng Q, Goel A, Huang M-D, Kempe D, de Espanés PM, Rothemund PWK (May 2002a) Combinatorial optimization problems in self-assembly. In: Proceedings of the 34th annual ACM symposium on theory of computing (STOC02), Montreal, Quebec, Canada, pp 23–32. doi:10.1145/509907.509913

  • Adleman L, Kari J, Kari L, Reishus D (November 2002b) On the decidability of self-assembly of infinite ribbons. In: Proceedings of the 43rd annual IEEE symposium on foundations of computer science (FOCS02), Ottawa, Ontario, Canada, pp 530–537

  • Aggarwal G, Cheng Q, Goldwasser MH, Kao M-Y, de Espanés PM, Schweller RT (2005) Complexities for generalized models of self-assembly. SIAM J Comput 34(6):1493–1515. doi:10.1137/S0097539704445202

    Article  MathSciNet  MATH  Google Scholar 

  • Barish R, Rothemund PWK, Winfree E (2005) Two computational primitives for algorithmic self-assembly: copying and counting. Nano Lett 5(12):2586–2592. doi:10.1021/nl052038l

    Article  Google Scholar 

  • Barish RD, Schulman R, Rothemund PWK, Winfree E (2009) An information-bearing seed for nucleating algorithmic self-assembly. Proc Natl Acad Sci USA. doi:10.1073/pnas.0808736106

  • Berger R (1966) The undecidability of the domino problem. Number 66 in Memoirs Series. American Mathematical Society, Providence, RI, USA

  • Braich R, Chelyapov N, Johnson CR, Rothemund PWK, Adleman L (2002) Solution of a 20-variable 3-SAT problem on a DNA computer. Science 296(5567):499–502. doi:10.1126/science.1069528

    Article  Google Scholar 

  • Brun Y (2007) Arithmetic computation in the tile assembly model: Addition and multiplication. Theor Comput Sci 378(1):17–31. ISSN 0304-3975. doi:10.1016/j.tcs.2006.10.025

    Google Scholar 

  • Brun Y (2008a) Nondeterministic polynomial time factoring in the tile assembly model. Theor Comput Sci 395(1):3–23. ISSN 0304-3975. doi:10.1016/j.tcs.2007.07.051

    Google Scholar 

  • Brun Y (2008b) Solving NP-complete problems in the tile assembly model. Theor Comput Sci 395(1):31–46. ISSN 0304-3975. doi:10.1016/j.tcs.2007.07.052

  • Brun Y (2008c) Solving satisfiability in the tile assembly model with a constant-size tileset. J Algorithm 63(4):151–166. ISSN 0196-6774. doi:10.1016/j.jalgor.2008.07.002

    Google Scholar 

  • Brun Y, Medvidovic N (2008) Preserving privacy in distributed computation via self-assembly. Technical Report USC-CSSE-2008-819, University of Southern California, Center for Software Engineering

  • Brun Y, Reishus D (2009) Path finding in the tile assembly model. Theor Comput Sci 410(15):1461–1472. ISSN 0304-3975. doi:10.1016/j.tcs.2008.12.008

    Google Scholar 

  • Chen K, Ramachandran V (2001) A space-efficient randomized DNA algorithm for k-SAT. DNA Comput LNCS 2054:199–208. doi:10.1007/3-540-44992-2_13

  • Demaine E, Demaine M, Fekete S, Ishaque M, Rafalin E, Schweller R (2008) Staged self-assembly: Nanomanufacture of arbitrary shapes with o(1) glues. In: Max G, Hao Y (eds) DNA computing, vol 4848. Berlin: Springer, pp 1–14. doi:10.1007/978-3-540-77962-9_1

  • Doty D, Patitz MJ, Reishus D, Schweller, RT, Summers SM (2010) Strong fault-tolerance for self-assembly with fuzzy temperature. In: Proceedings of the 51st annual IEEE symposium on foundations of computer science (FOCS10), pp 417–426. doi:10.1109/FOCS.2010.47

  • Fujibayashi K, Zhang DY, Winfree E, Murata S (2009) Error suppression mechanisms for DNA tile self-assembly and their simulation. Nat Comput 8:589–612. ISSN 1567-7818. doi:10.1007/s11047-008-9093-9

    Google Scholar 

  • Kao M-Y, Schweller R (January 2006) Reducing tile complexity for self-assembly through temperature programming. In: Proceedings of the 17th annual ACM-SIAM symposium on discrete algorithms (SODA06), Miami, FL, USA, pp 571–580. doi:10.1145/1109557.1109620

  • Kullmann O (1997) Worst-case analysis, 3-SAT decision and lower bounds: approaches for improved SAT algorithms. DIMACS Ser Discret Math Theor Comput Sci 35:261–313

    MathSciNet  Google Scholar 

  • Kullmann O (1999) New methods for 3-SAT decisions and worst-case analysis. Theor Comput Sci 223:1–72. doi:10.1016/S0304-3975(98)00017-6

    Article  MathSciNet  MATH  Google Scholar 

  • Lagoudakis MG, LaBean TH (1999) 2D DNA self-assembly for satisfiability. DIMACS Ser Discret Math Theor Comput Sci 54:141–154

    Google Scholar 

  • McLurkin J, Smith J, Frankel J, Sotkowitz D, Blau D, Schmidt B (March 2006) Speaking swarmish: human-robot interface design for large swarms of autonomous mobile robots. In Proceedings of the AAAI spring symposium, Stanford, CA, USA

  • Monien B, Speckenmeyer E (1985) Solving satisfiability in less than 2n steps. Discrete Appl Math 10(3):287–296. doi:10.1016/0166-218X(85)90050-2

    Article  MathSciNet  MATH  Google Scholar 

  • Paturi R, Pudlák P, Zane F (1997) Satisfiability coding lemma. In: Proceedings of the 38th annual symposium on foundations of computer science (FOCS97), Miami Beach, FL, USA, pp 566–574. ISBN 0-8186-8197-7. doi:10.1109/SFCS.1997.646146

  • Robinson RM (1971) Undecidability and nonperiodicity for tilings of the plane. Invent Math 12(3):177–209

    Article  MathSciNet  Google Scholar 

  • Rothemund PWK, Winfree E (May 2000) The program-size complexity of self-assembled squares. In: Proceedings of the 32nd annual ACM symposium on theory of computing (STOC00), Portland, OR, USA, pp 459–468. doi:10.1145/335305.335358

  • Rothemund PWK, Papadakis N, Winfree E (2004) Algorithmic self-assembly of DNA Sierpinski triangles. PLoS Biol 2(12):e424. doi:10.1371/journal.pbio.0020424

    Article  Google Scholar 

  • Sakamoto K, Gouzu H, Komiya K, Kiga D, Yokoyama S, Yokomori T (2000) Molecular computation by DNA hairpin formation. Science, 288(5469):1223–1226. doi:10.1126/science.288.5469.1223

    Article  Google Scholar 

  • Schiermeyer I (1993) Solving 3-satisfiability in less than 1.579n steps. Comput Sci Logic 702:379–394

    Article  MathSciNet  Google Scholar 

  • Sipser M (1997) Introduction to the theory of computation. PWS Publishing Company

  • Soloveichik D, Winfree E (2007) Complexity of self-assembled shapes. SIAM J Comput 36(6):1544–1569. doi:10.1137/S0097539704446712

    Article  MathSciNet  MATH  Google Scholar 

  • Wang H (1961) Proving theorems by pattern recognition. II. Bell Syst Tech J 40:1–42

    Google Scholar 

  • Wang H (1962) An unsolvable problem on dominoes. Technical Report BL30 (II-15), Harvard Computation Laboratory

  • Winfree E (1998a) Simulations of computing by self-assembly of DNA. Technical Report CS-TR:1998:22. California Institute of Technology, Pasadena, CA

  • Winfree E (1998b) Algorithmic self-assembly of DNA. PhD thesis, California Institute of Technology, Pasadena, CA, USA, June

  • Winfree E, Bekbolatov R (June 2003) Proofreading tile sets: error correction for algorithmic self-assembly. In: Proceedings of the 43rd annual IEEE symposium on foundations of computer science (FOCS02), vol 2943, pp 126–144, Madison, WI, USA. doi:10.1007/978-3-540-24628-2_13

  • Winfree E, Yang X, Seeman NC (1998) Universal computation via self-assembly of DNA: some theory and experiments. DNA Based Computers II, pp 191–213

  • Woeginger GJ (2003) Exact algorithms for NP-hard problems: a survey. Combinatorial Optimization - Eureka, You Shrink! 2570:185–207. doi:10.1007/3-540-36478-1_17

  • Yin P, Hariadi RF, Sahu S, Choi HMT, Park SH LaBean TH, Reif JH (2008) Programming DNA tube circumferences. Science 321(5890):824–826. doi:10.1126/science.1157312

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yuriy Brun.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brun, Y. Efficient 3-SAT algorithms in the tile assembly model. Nat Comput 11, 209–229 (2012). https://doi.org/10.1007/s11047-011-9299-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11047-011-9299-0

Keywords

Navigation