Abstract
A practical intra-cellular biomolecular computer should work inside living cells without damaging them. The retrovirus-based biomolecular computer has been designed, by mimicking the natural processes of living cells, to enable the creation of a practical intra-cellular computer. Here, I review the idea of retrovirus-based computing, and examine its feasibility. This idea might lead to the development of new technologies not only for biological research, but also for medical purposes. In future, through the development of the in vivo retrovirus-based computer, gene diagnosis and gene therapy is expected to cooperatively work inside living cells, enabling intelligent gene therapy technology that uses biomolecular computing.
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References
LM Adleman (1994) ArticleTitleMolecular computation of solutions to combinatorial problems Science 266 1021–1024 Occurrence Handle7973651
Y Benenson T Paz-Elizur R Adar E Keinan Z Livneh E Shapiro (2001) ArticleTitleProgrammable and autonomous computing machine made of biomolecules Nature 414 430–434 Occurrence Handle10.1038/35106533 Occurrence Handle11719800
VV Didenko (2001) ArticleTitleDNA probes using fluorescence resonance energy transfer (FRET): designs and applications Biotechniques 31 1106–1121 Occurrence Handle11730017
R Ehricht T Kirner T Ellinger P Foerster JS McCaskill (1997) ArticleTitleMonitoring the amplification of CATCH, a 3SR based cooperatively coupled isothermal amplification system, by fluorimetric methods Nucleic Acids Research 25 4697–4699 Occurrence Handle10.1093/nar/25.22.4697 Occurrence Handle9358187
JC Guatelli KM Whitfield DY Kwoh KJ Barringer DD Richman TR Gingeras (1990) ArticleTitleIsothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication Proceedings of the National Academy of Sciences of the United States of America 87 1874–1878 Occurrence Handle2308948
RJ Lipton (1995) ArticleTitleDNA solution of hard computational problems Science 268 542–545 Occurrence Handle7725098
J Mak L Kleiman (1997) ArticleTitlePrimer tRNAs for reverse transcription Journal of Virology 71 87–95
C Mao TH LaBean JH Relf NC Seeman (2000) ArticleTitleLogical computation using algorithmic self-assembly of DNA triple-crossover molecules. Nature 407 493–496 Occurrence Handle10.1038/35035038 Occurrence Handle11028996
JF Milligan DR Groebe GW Witherell OC Uhlenbeck (1987) ArticleTitleOligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates Nucleic Acids Research 15 8783–8798 Occurrence Handle3684574
N Nishida M Wakui K Tokunaga A Suyama (2001) Highly specific and quantitative gene expression profiling based on DNA computing H Matsuda S Miyano T Takagi L Wong (Eds) Genome Informatics Universal Academy Press Tokyo 259–260
Nitta N and Symana A (2004) Autonomous Biomolecular Computer Modeled after Retroviral Replication. In: Chen J and Reif J (eds). DNA Computing, 9th International Workshop on DNA Based Computers, DNA9, Madison, WI, USA, June 2003, Revised Papers. Lecture Notes in Computer Science 2943: 203–212.
JA Rose RJ Deaton M Hagiya A Suyama (2002) ArticleTitleEquilibrium analysis of the efficiency of an autonomous molecular computer Physical Review E 65 021910 Occurrence Handle10.1103/PhysRevE.65.021910
K Sakamoto D Kiga K Komiya H Gouzu S Yokoyama S Ikeda H Sugiyama M Hagiya (1999) ArticleTitleState transitions by molecules Biosystems 52 81–91 Occurrence Handle10.1016/S0303-2647(99)00035-0 Occurrence Handle10636033
A Suyama N Nishida K Kurata Omagari K (2000) Gene expression analysis by DNA computing S Miyano R Shamir T Takagi (Eds) Currents in Computational Molecular Biology Universal Academy Press Tokyo 12–13
M Wilhelm FX Wilhelm (2001) ArticleTitleReverse transcription of retroviruses and LTR retrotransposons Cellular and Molecular Life Sciences 58 1246–1262 Occurrence Handle11577982
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Nitta, N. Retrovirus-based computer. Nat Comput 4, 127–139 (2005). https://doi.org/10.1007/s11047-004-4008-x
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DOI: https://doi.org/10.1007/s11047-004-4008-x