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Clinical Characteristics and Outcomes of Candidemia Caused by Meyerozyma guilliermondii Complex in Cancer Patients Undergoing Surgery

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Abstract

Although Meyerozyma guilliermondii complex is an uncommon cause of invasive candidiasis worldwide, reported cases, mainly regarding bloodstream infections, increased over years, and patients with cancer who have undergone recent surgery are most commonly affected. However, the clinical characteristics and outcomes of candidemia caused by M. guilliermondii complex remain poorly understood. A retrospective case–control study was conducted to evaluate the clinical characteristics and mortality of candidemia caused by M. guilliermondii complex in cancer patients undergoing surgery. Demographic and clinical data were collected from the hospital medical records system with a standardized data collection form and were analyzed with SPSS 20.0. Sixty-six cancer patients who have undergone recent surgery and were diagnosed with candidemia caused by M. guilliermondii complex were included in the study. Regarding the clinical manifestations, most patients’ body temperatures ranged from 38 to 40 °C, with a median fever duration of 4 (IQR: 3–6) days. Multivariate analysis indicated that the presence of central venous catheter (OR: 6.68; 95% CI 2.80–15.94) and gastric tube (OR: 3.55; 95% CI 1.22–10.34) were independent risk factors for M. guilliermondii complex fungemia. The 30-day crude mortality of candidemia caused by M. guilliermondii complex was 12.1%, twice that of the control group. Moreover, increased WBC count, age ≥ 60 years, septic shock, and ICU admission were identified as predictors of mortality through univariate analysis. These findings will provide a foundation for the clinical management of candidemia caused by M. guilliermondii complex in post-surgical cancer patients.

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WHONET 5.6 was used.

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Acknowledgements

We appreciate Hengrui Liang from the Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, for kindly assisting with manuscript revision.

Funding

This work was supported by the Laboratory Medicine Innovation Unit, Chinese Academy of Medical Sciences (2019RU017) and National Key Specialist Construction Project for Clinical Laboratory Medicine.

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Authors and Affiliations

  1. Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

    Jingjing Chen, Sufei Tian, Fushun Li, Guoquan Sun, Ke Yun, Shitong Cheng & Yunzhuo Chu

  2. National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

    Jingjing Chen, Sufei Tian, Fushun Li, Guoquan Sun, Ke Yun, Shitong Cheng & Yunzhuo Chu

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  1. Jingjing Chen
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  2. Sufei Tian
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Contributions

Yunzhuo Chu conceived and designed the study; Jingjing Chen and Fushun Li collected the data; Sufei Tian and Ke Yun analyzed the data; Jingjing Chen, Shitong Cheng, and Guoquan Sun wrote the manuscript.

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Correspondence to Yunzhuo Chu.

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This study was approved by the Medical Ethics Committees of the First Hospital of China Medical University.

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Chen, J., Tian, S., Li, F. et al. Clinical Characteristics and Outcomes of Candidemia Caused by Meyerozyma guilliermondii Complex in Cancer Patients Undergoing Surgery. Mycopathologia 185, 975–982 (2020). https://doi.org/10.1007/s11046-020-00485-2

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  • DOI: https://doi.org/10.1007/s11046-020-00485-2

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