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Complete Genome Sequence of Candida theae from Hickman Line Infection in an Immunocompromised Child

Abstract

We present the first whole-genome-sequencing data of a rare fungal species, Candida theae isolated in the context of a Hickman line infection in a patient with juvenile myelomonocytic leukaemia. To our knowledge, this is the first instance of publicly available genomic data for this species. Loci associated with antifungal resistance were referenced against its closely related members of the Candida parapsilosis complex.

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Acknowledgements

This research is supported by the NUHS Internal Grant Funding under the NUHS Seed Fund (NUHSRO/2018/082/RO5+5/Seed-Aug/08).

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Contributions

KLC, SO, JT conceived and planned the experiments. SO and JT performed genomic analysis. KLC contributed clinical input. KLC took the lead in writing the manuscript. All authors provided critical feedback and helped shape the research, analysis and manuscript.

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Correspondence to Jeanette W. P. Teo.

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The authors have no conflict of interest to declare.

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Chew, K.L., Octavia, S. & Teo, J.W.P. Complete Genome Sequence of Candida theae from Hickman Line Infection in an Immunocompromised Child. Mycopathologia 185, 727–729 (2020). https://doi.org/10.1007/s11046-020-00476-3

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  • DOI: https://doi.org/10.1007/s11046-020-00476-3

Keywords

  • Whole-genome-sequencing
  • Candida theae
  • Antifungal susceptibility
  • 5-Flucytosine resistance
  • Antimicrobial resistance